Stroke Volume

Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-gamma) and late (e.g., high mobility group box 1 (HMGB1) protein) proinflammatory cytokines. The recent discovery of HMGB1 as a late mediator of lethal sepsis has prompted investigation for development of new experimental therapeutics.

Author(s): 
Li, Wei
Li, Jianhua
Ashok, Mala
Wu, Rongqian
Chen, Dazhi
Yang, Lihong
Yang, Huan
Tracey, Kevin J.
Wang, Ping
Sama, Andrew E.
Wang, Haichao
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Glucose-mediated oxidative stress and the upregulation of cyclooxygenase (COX)-2 pathway activity have been implicated in the pathogenesis of several vascular complications of diabetes including diabetic neuropathy. However, in nondiabetic subjects, the cardiovascular safety of selective COX-2 inhibition is controversial. The aim of this study was to explore the links between hyperglycemia, oxidative stress, activation of the COX-2 pathway, cardiac sympathetic integrity, and the development of left ventricular (LV) dysfunction in experimental diabetes.

Author(s): 
Kellogg, Aaron P.
Converso, Kimber
Wiggin, Tim
Stevens, Martin
Pop-Busui, Rodica
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Metabolic syndrome (MetS) represents an increased risk of cardiovascular disease. Although its individual components adversely affect cardiac structure and function, the extent to which multiple components of MetS affect the cardiac extracellular matrix (ECM) has not been well characterized. Lysyl oxidase (LOX) is one of the cardiac ECM-modifying enzymes that catalyze the formation of collagen cross-linking. Our objective was to define the effect of diet-induced MetS on the LOX enzyme.

Author(s): 
Zibadi, Sherma
Vazquez, Randy
Moore, Derek
Larson, Douglas F.
Watson, Ronald R.
Publication Title: 
Archives of Internal Medicine

BACKGROUND: Preliminary evidence suggests that meditative exercise may have benefits for patients with chronic systolic heart failure (HF); this has not been rigorously tested in a large clinical sample. We sought to investigate whether tai chi, as an adjunct to standard care, improves functional capacity and quality of life in patients with HF.

Author(s): 
Yeh, Gloria Y.
McCarthy, Ellen P.
Wayne, Peter M.
Stevenson, Lynne W.
Wood, Malissa J.
Forman, Daniel
Davis, Roger B.
Phillips, Russell S.
Publication Title: 
Journal of Molecular and Cellular Cardiology

Following myocardial infarction (MI), activated macrophages infiltrate into the necrotic myocardium as part of a robust pro-inflammatory response and secrete matrix metalloproteinase-9 (MMP-9). Macrophage activation, in turn, modulates the fibrotic response, in part by stimulating fibroblast extracellular matrix (ECM) synthesis. We hypothesized that overexpression of human MMP-9 in mouse macrophages would amplify the inflammatory and fibrotic responses to exacerbate left ventricular dysfunction.

Author(s): 
Zamilpa, Rogelio
Ibarra, Jessica
de Castro Brás, Lisandra E.
Ramirez, Trevi A.
Nguyen, Nguyen
Halade, Ganesh V.
Zhang, Jianhua
Dai, Qiuxia
Dayah, Tariq
Chiao, Ying Ann
Lowell, Wesley
Ahuja, Seema S.
D'Armiento, Jeanine
Jin, Yu-Fang
Lindsey, Merry L.
Publication Title: 
Fortschritte Der Medizin

The pathophysiology of anaphylactic and anaphylactoid shock states suggests that the rapidly initiated, intensive therapeutic measures to be taken must involve: breathing (ventilation) of (with) 100% oxygen, continuous or semi-continuous sympathicomimetic therapy (epinephrine, isoprenalin, orciprenalin) avoiding excessive single doses, rapid intensive volume substitution, control of metabolic acidosis, bronchospasmolytic therapy, in case of laryngospasm intubation, if not possible coniotomy or transtracheal punction.

Author(s): 
Pavek, K.
Wegmann, A.
Publication Title: 
Voprosy Kurortologii, Fizioterapii, I Lechebnoĭ Fizicheskoĭ Kultury

The present study was designed to study the influence of classical back and neck massage on the functional state of the cardiovascular system and its regulation under conditions of short-term physical loading in the healthy adolescents. It was shown that a course of classical massage promoted the reduction of arterial pressure in all children and the heart rate frequency in the boys. This effect was apparent as a reaction of blood circulation to the dosed physical exercises manifested as a rise in the heart rate frequency and stroke volume.

Author(s): 
Sibir'ianov, A. R.
Sergeeva, N. V.
Podzolko, T. Iu
Publication Title: 
Journal of Neurology, Neurosurgery, and Psychiatry

A 69 year old man is described with a 12 year history of intermittent syncope associated with ingesting solid food, mainly after having fasted. He was taking enalapril, propranolol, bendrofluazide (bendroflumethiazide), omeprazole, finasteride, and aspirin. Detailed investigations, including gastrointestinal evaluation, measurement of various gut hormones, and autonomic testing, indicated no abnormality. A liquid meal, performed before fasting, failed to elicit an episode. However, a solid meal after an overnight fast provoked near-syncope.

Author(s): 
Deguchi, K.
Mathias, C. J.
Publication Title: 
The Journal of Nutritional Biochemistry

It has been reported that dietary energy restriction, including intermittent fasting (IF), can protect heart and brain cells against injury and improve functional outcome in animal models of myocardial infarction (MI) and stroke. Here we report that IF improves glycemic control and protects the myocardium against ischemia-induced cell damage and inflammation in rats.

Author(s): 
Wan, Ruiqian
Ahmet, Ismayil
Brown, Martin
Cheng, Aiwu
Kamimura, Naomi
Talan, Mark
Mattson, Mark P.
Publication Title: 
PloS One

BACKGROUND: Chronic heart failure (CHF) is a global public health problem. Therefore, novel and effective drugs that show few side-effects are needed. Early literature studies indicated that Huangqi injection is one of the most commonly used traditional Chinese patent medicines for CHF in China. As a large number of clinical studies has been carried out and published, it is essential to evaluate the effectiveness and safety of Huangqi injection. Therefore, we carried out this systematic review under the support of the framework of the Joint Sino-Italian Laboratory (JoSIL).

Author(s): 
Fu, Shufei
Zhang, Junhua
Menniti-Ippolito, Francesca
Gao, Xiumei
Galeotti, Francesca
Massari, Marco
Hu, Limin
Zhang, Boli
Ferrelli, Rita
Fauci, Alice
Firenzuoli, Fabio
Shang, Hongcai
Guerra, Ranieri
Raschetti, Roberto

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