Sucralfate

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Heartburn is one of the most common gastrointestinal symptoms in pregnant women. It can occur in all trimesters of pregnancy. The symptoms of heartburn in pregnancy may be frequent, severe and distressing, but serious complications are rare. Many interventions have been used for the treatment of heartburn in pregnancy. These interventions include advice on diet, lifestyle modification and medications. However, there has been no evidence-based recommendation for the treatment of heartburn in pregnancy.

Author(s): 
Phupong, Vorapong
Hanprasertpong, Tharangrut
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models.

Author(s): 
Mishra, Vaibhav
Agrawal, Manali
Onasanwo, Samuel Adetunji
Madhur, Gaurav
Rastogi, Preeti
Pandey, Haushila Prasad
Palit, Gautam
Narender, Tadigoppula
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Bacopa monniera Wettst. (BM, syn. Herpestis monniera L; Scrophulariaceae), is an Ayurvedic drug used as a rasayana. Its fresh juice was earlier reported to have significant antiulcerogenic activity. In continuation, methanolic extract of BM (BME) standardized to bacoside-A content (percentage-38.0 +/- 0.9), when given in the dose of 10-50 mg/kg, twice daily for 5 days, showed dose-dependent anti-ulcerogenic on various gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation.

Author(s): 
Sairam, K.
Rao, C. V.
Babu, M. D.
Goel, R. K.
Publication Title: 
Journal of Medicinal Food

Cissus quadrangularis is an indigenous plant commonly mentioned in Ayurveda for treatment of gastric ulcers. The ulcer-protective effect of a methanolic extract of C. quadrangularis (CQE) was comparable to that of the reference drug sucralfate. Further, gastric juice and mucosal studies showed that CQE at a dose of 500 mg/kg given for 10 days significantly increased the mucosal defensive factors like mucin secretion, mucosal cell proliferation, glycoproteins, and life span of cells.

Author(s): 
Jainu, Mallika
Devi, C. S. Shyamala
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