Suicidal Ideation

Publication Title: 
Trends in Neurosciences

Suicide and related behaviors are complex phenomena associated with different risk factors. Although most individuals who display suicidal behavior do not have a history of early-life adversity, a significant minority does. Recent animal and human data have suggested that early-life adversity leads to epigenetic regulation of genes involved in stress-response systems.

Author(s): 
Turecki, Gustavo
Ernst, Carl
Jollant, Fabrice
LabontÈ, Benoit
Mechawar, Naguib
Publication Title: 
Journal of Affective Disorders

INTRODUCTION: Suicide is a major health problem, and depression is a major psychiatric cause of suicide. Suicide is influenced by the multifactorial interaction of many risk factors. Therefore, epigenetic research may lead to understandings that are applicable to suicide. This study investigated whether epigenetic changes are associated with suicidal behavior and evaluated the treatment outcome of suicidal ideation in depressive patients. METHODS: In 108 patients with major depression, the promoter methylation of the gene encoding brain-derived neurotrophic factor (BDNF) was measured.

Author(s): 
Kang, Hee-Ju
Kim, Jae-Min
Lee, Ju-Yeon
Kim, Seon-Young
Bae, Kyung-Yeol
Kim, Sung-Wan
Shin, Il-Seon
Kim, Hye-Ran
Shin, Myung-Geun
Yoon, Jin-Sang
Publication Title: 
Collegium Antropologicum

The psychopathological dynamics in suicidality overcomes actual diagnostic distribution therefore pharmacotherapy has restricted role in overall prevention of suicidal behaviour among mentally ill and is demanding for clinician. This role is achieved through reduction and alleviation of suicidal risk with rational and individual pharmacotherapeutic approach emphasising effective, safe and tolerable treatment. The genetic and epigenetic factors, dysfunction of neurotransmitter, neuroendocrine system and stress response system has been determining for neurobiology of suicidality.

Author(s): 
Filakovi?, Pavo
Eri?, Anamarija Petek
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVES: Brain-derived neurotrophic factor (BDNF) has been considered a risk factor for suicidal behavior in adult populations. BDNF secretion is influenced by epigenetic (DNA promoter methylation) and genetic (val66met polymorphism) profiles. We investigated the independent and interactive effects of BDNF methylation status and val66met polymorphisms on late-life suicidal ideation. METHODS: In total, 732 Korean community residents aged 65+ years were evaluated; of 639 without suicidal ideation, 579 (90.6%) were followed up 2 years later.

Author(s): 
Kim, Jae-Min
Kang, Hee-Ju
Bae, Kyung-Yeol
Kim, Sung-Wan
Shin, Il-Seon
Kim, Hye-Ran
Shin, Myung-Geun
Yoon, Jin-Sang
Publication Title: 
The American Journal of Psychiatry

Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding that was extended to peripheral blood samples from other cohorts of prospectively followed individuals.

Author(s): 
Guintivano, Jerry
Brown, Tori
Newcomer, Alison
Jones, Marcus
Cox, Olivia
Maher, Brion S.
Eaton, William W.
Payne, Jennifer L.
Wilcox, Holly C.
Kaminsky, Zachary A.
Publication Title: 
American Journal of Preventive Medicine

Suicide and suicidal behaviors are complex, heterogeneous phenomena that are thought to result from the interactions among distal factors increasing predisposition and proximal factors acting as precipitants. Epigenetic factors are likely to act both distally and proximally. Aspirational Goal 1 aims to find clear targets for suicide and suicidal behavior intervention through greater understanding of the interplay among the biological, psychological, and social risk and protective factors associated with suicide.

Author(s): 
Turecki, Gustavo
Publication Title: 
International Journal of Psychiatry in Medicine

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has been considered a risk factor for suicidality. BDNF secretion is influenced by epigenetic (DNA methylation) and genetic (val66met polymorphism) profiles. We aimed to investigate the independent effects of BDNF promoter methylation status on suicidal ideation as well as the effects of its interaction with the val66met polymorphism in patients with breast cancer. METHODS: A total of279 patients with breast cancer were evaluated 1 week after breast surgery, and 244 (87%) were followed up 1 year later.

Author(s): 
Kim, Jae-Min
Kang, Hee-Ju
Kim, Seon-Young
Kim, Sung-Wan
Shin, Il-Seon
Kim, Hye-Ran
Park, Min-Ho
Shin, Myung-Geun
Yoon, Jung-Han
Yoon, Jin-Sang
Publication Title: 
Translational Psychiatry

Traumatic stress results in hypothalamic pituitary adrenal (HPA) axis abnormalities and an increased risk to both suicidal behaviors and post-traumatic stress disorder (PTSD). Previous work out of our laboratory identified SKA2 DNA methylation associations with suicidal behavior in the blood and brain of multiple cohorts. Interaction of SKA2 with stress predicted suicidal behavior with ~80% accuracy. SKA2 is hypothesized to reduce the ability to suppress cortisol following stress, which is of potentially high relevance in traumatized populations.

Author(s): 
Kaminsky, Z.
Wilcox, H. C.
Eaton, W. W.
Van Eck, K.
Kilaru, V.
Jovanovic, T.
Klengel, T.
Bradley, B.
Binder, E. B.
Ressler, K. J.
Smith, A. K.
Publication Title: 
Depression and Anxiety

BACKGROUND: DNA methylation of the SKA2 gene has recently been implicated as a biomarker of suicide risk and posttraumatic stress disorder (PTSD). To examine the specificity and reliability of these findings, we examined associations between SKA2 DNA methylation, broad dimensions of psychiatric symptoms, and suicide phenotypes in adults with high levels of trauma exposure. METHODS: A total of 466 White, non-Hispanic veterans and their intimate partners (65% male) underwent clinical assessment and had blood drawn for genotyping and methylation analysis.

Author(s): 
Sadeh, Naomi
Wolf, Erika J.
Logue, Mark W.
Hayes, Jasmeet P.
Stone, Annjanette
Griffin, L. Michelle
Schichman, Steven A.
Miller, Mark W.
Publication Title: 
PloS One

BACKGROUND: The high incidence of pesticide ingestion as a means to commit suicide is a critical public health problem. An important predictor of suicidal behavior is suicide ideation, which is related to stress. However, studies on how to defend against stress-induced suicidal thoughts are limited. OBJECTIVE: This study explores the impact of stress on suicidal ideation by investigating the mediating effect of self-efficacy and dispositional optimism.

Author(s): 
Feng, Jun
Li, Shusheng
Chen, Huawen

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