Sulfalene

Publication Title: 
Annals of Clinical Microbiology and Antimicrobials

BACKGROUND: Artemisinin-based combination therapy is increasingly being adopted as first-line antimalarial therapy. The choice of appropriate therapy depends on efficacy, cost, side effects, and simplicity of administration.

Author(s): 
Adam, Ishag
Magzoub, Mamoun
Osman, Maha E.
Khalil, Insaf F.
Alifrangis, Michael
Elmardi, Khalid A.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The choice of artemisinin-based combination that is being adopted for malaria treatment in sub-Saharan Africa may depend on several factors, including cost, efficacy, side effects, and simplicity of administration. We tested the hypothesis that artesunate-sulfamethoxypyrazine-pyrimethamine is as efficacious as the four-dose regimen of artemether-lumefantrine for treatment of Plasmodium falciparum malaria. The study was carried out during two transmission seasons (2003 and 2004) in Sotuba, Mali. Participants at least 6 months of age with uncomplicated P.

Author(s): 
Sagara, Issaka
Dicko, Alassane
Djimde, Abdoulaye
Guindo, Ousmane
Kone, Mamady
Tolo, Youssouf
Thera, Mahamadou A.
Sogoba, Moussa
Fofana, Moussa
Ouattara, Amed
Sissoko, Mady
Jansen, Herwig F.
Doumbo, Ogobara K.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The treatment efficacy and effects of artemether-lumefantrine (AL) and amodiaquine-sulfalene-pyrimethamine (ASP) on gametocyte carriage were evaluated in 181 children < or = 10 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive either drug combination. All children recovered clinically. Fever clearance times were similar. The rate of P. falciparum reappearance (recrudescence or re-infection) between two and six weeks after the start of therapy was significantly higher in AL-treated children (P = 0.01).

Author(s): 
Sowunmi, Akintunde
Gbotosho, Grace O.
Happi, Christian T.
Adedeji, Ahmed A.
Fehintola, Fatai A.
Folarin, Onikepe A.
Tambo, Ernest
Fateye, Babasola A.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

In view of the changing policy towards artemisinin-based combination therapies (ACTs), the efficacy, tolerance, and degree of re-infection of two ACTs were investigated: artesunate plus sulfadoxine/pyrimethamine (As + SP) and AS plus sulfamethoxypyrazine/pyrimethamine (As + SMP). One hundred three children were assigned to receive As + SP and 109 to receive As + SMP.

Author(s): 
Rulisa, Stephen
Gatarayiha, Jean Philip
Kabarisa, Tharcisse
Ndayisaba, Gill
Publication Title: 
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases

OBJECTIVES: Malaria kills approximately 1.5 to 2.7 million people each year. Despite the introduction of artemisinin-based combination therapies (ACTs), the treatment of malaria is hampered by problems such as inadequate efficacy, recrudescence, early re-infection, low patient compliance, and high cost price of drugs.

Author(s): 
Penali, Louis Koné
Jansen, Frans Herwig
Publication Title: 
Malaria Journal

BACKGROUND: The efficacy of artemisinin-based combination therapy has already been demonstrated in a number of studies all over the world, and some of them can be regarded as comparably effective. Ease of administration of anti-malarial treatments with shorter courses and fewer tablets may be key determinant of compliance. METHODS: Patients with uncomplicated falciparum malaria and over six months of age were recruited in Cameroon, Mali, Rwanda and Sudan.

Author(s): 
Sagara, Issaka
Rulisa, Stephen
Mbacham, Wilfred
Adam, Ishag
Sissoko, Kourane
Maiga, Hamma
Traore, Oumar B.
Dara, Niawanlou
Dicko, Yahia T.
Dicko, Alassane
Djimde, Abdoulaye
Jansen, F. Herwig
Doumbo, Ogobara K.
Publication Title: 
PloS One

BACKGROUND: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. METHODOLOGY/PRINCIPAL FINDINGS: The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29.

Author(s): 
Sissoko, Mahamadou S.
Dabo, Abdoulaye
Traoré, Hamidou
Diallo, Mouctar
Traoré, Boubacar
Konaté, Drissa
Niaré, Boubacar
Diakité, Moussa
Kamaté, Bourama
Traoré, Abdrahamane
Bathily, Aboudramane
Tapily, Amadou
Touré, Ousmane B.
Cauwenbergh, Sarah
Jansen, Herwig F.
Doumbo, Ogobara K.
Publication Title: 
Malaria Journal

BACKGROUND: Several studies have demonstrated the efficacy of artemisinin-combination therapy (ACT) across malaria zones of the world. Fixed dose ACT with shorter courses and fewer tablets may be key determinants to ease of administration and compliance. METHODS: Children aged one year to 13 years presenting with uncomplicated Plasmodium falciparum malaria were recruited in Ibadan, south-western Nigeria.

Author(s): 
Ayede, Idowu Adejumoke
Falade, Adegoke Gbadegesin
Sowunmi, Akintunde
Jansen, Frans Herwig
Publication Title: 
Malaria Journal

Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi.

Author(s): 
Jansen, Frans Herwig
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