Publication Title: 
Nature Medicine

Epileptic seizures are a common and poorly understood comorbidity for individuals with primary brain tumors. To investigate peritumoral seizure etiology, we implanted human-derived glioma cells into severe combined immunodeficient mice. Within 14-18 d, glioma-bearing mice developed spontaneous and recurring abnormal electroencephalogram events consistent with progressive epileptic activity. Acute brain slices from these mice showed marked glutamate release from the tumor mediated by the system x(c)(-) cystine-glutamate transporter (encoded by Slc7a11).

Buckingham, Susan C.
Campbell, Susan L.
Haas, Brian R.
Montana, Vedrana
Robel, Stefanie
Ogunrinu, Toyin
Sontheimer, Harald
Publication Title: 
World journal of gastroenterology: WJG

AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn's disease (CD) in patients who have achieved remission, who are a high-risk group for relapse. METHODS: A prospective, single center, 2-year clinical trial was conducted. Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.

Chiba, Mitsuro
Abe, Toru
Tsuda, Hidehiko
Sugawara, Takeshi
Tsuda, Satoko
Tozawa, Haruhiko
Fujiwara, Katsuhiko
Imai, Hideo
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To analyze the indications of the therapies for rheumatoid arthritis (RA) with neural network model analysis. METHODS: Three hundred and ninety-seven patients were included in the clinical trial from 9 clinical centers. They were randomly divided into Western medicine (WM) treated group, 194 cases; and traditional Chinese herbal medicine (CM) treated group, 203 cases. A complete physical examination and 18 common clinical manifestations were prepared before the randomization and after the treatment.

Zha, Qing-lin
He, Yi-Ting
Yan, Xiao-ping
Su, Li
Song, Yue-jin
Zeng, Sheng-ping
Liu, Wei
Feng, Xing-hua
Qian, Xian
Zhu, Wan-hua
Lin, Se-qi
Lu, Cheng
Lu, Ai-Ping
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To evaluate the therapeutic effect of medicated moxibustion plus administration of salicylazosulfapyridine (SASP) and methotrexate (MTX) for treatment of active ankylosing spondylitis (AS). METHOD: Ninety cases of active AS were randomly assigned to Group A, B and C (N = 30 in each group), and treated respectively with SASP and MTX, acupuncture plus SASP and MTX, and composite sulfur (tablet) moxibustion plus SASP and MTX for 3 successive courses (2 months each course with an interval of 5 days).

Jia, Jie
Wang, Qiyin
Zhang, Tiehan
Li, Jun
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