Publication Title: 
Biochemical Pharmacology
Morita, K.
Yamamoto, I.
Iwata, H.
Publication Title: 
Journal of Medicinal Chemistry

Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.

Slack, Rachel D.
Mott, Bryan T.
Woodard, Lauren E.
Tripathi, Abhai
Triphati, Abhai
Sullivan, David
Nenortas, Elizabeth
Girdwood, Sonya C. T.
Shapiro, Theresa A.
Posner, Gary H.
Publication Title: 
PloS One

INTRODUCTION: Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death. HS treatment has shown promising results as a therapy for cardio- and neuro- pathology. This study investigates the effects of fast (NaHS) and slow (GYY4137) HS-releasing drugs on the growth and metabolism of P. falciparum and the development of P. berghei ANKA CM.

DellaValle, Brian
Staalsoe, Trine
Kurtzhals, Jørgen Anders Lindholm
Hempel, Casper
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Realgar (As(4)S(4)) and cinnabar (HgS) are frequently included in traditional Chinese medicines and Indian Ayurvedic medicines. Both As and Hg are well known for toxic effects, and their safety is of concern. The aim of this study was to compare chronic nephrotoxicity of An-Gong-Niu-Huang Wan (AGNH), realgar and cinnabar with common arsenicals and mercurials.

Lu, Yuan-Fu
Wu, Qin
Yan, Jun-Wen
Shi, Jing-Zhen
Liu, Jie
Shi, Jing-Shan
Publication Title: 
Journal of Agricultural and Food Chemistry

In support of a new clinical trial designed to compare the effects of crushed fresh garlic and two types of garlic supplement tablets (enteric-coated dried fresh garlic and dried aged garlic extract) on serum lipids, the three garlic products have been characterized for (a) composition (14 sulfur and 2 non-sulfur compounds), (b) stability of suspected active compounds, and (c) availability of allyl thiosulfinates (mainly allicin) under both simulated gastrointestinal (tablet dissolution) conditions and in vivo.

Lawson, Larry D.
Gardner, Christopher D.
Publication Title: 

AIM OF THE STUDY: Sudden cardiac arrest (CA) is one of the leading causes of death worldwide. Previously we demonstrated that administration of sodium sulfide (Na(2)S), a hydrogen sulfide (H(2)S) donor, markedly improved the neurological outcome and survival rate at 24 h after CA and cardiopulmonary resuscitation (CPR) in mice. In this study, we sought to elucidate the mechanism responsible for the neuroprotective effects of Na(2)S and its impact on the long-term survival after CA/CPR in mice.

Kida, Kotaro
Minamishima, Shizuka
Wang, Huifang
Ren, JiaQian
Yigitkanli, Kazim
Nozari, Ala
Mandeville, Joseph B.
Liu, Philip K.
Liu, Christina H.
Ichinose, Fumito
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Our objectives are to investigate these observations and determine the role of isothiocyanates in primary or secondary bladder cancer prevention. METHODS AND RESULTS: We initially investigate the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal, noninvasive (RT4), and invasive (J82, UMUC3) human urothelial cell viability.

Abbaoui, Besma
Riedl, Kenneth M.
Ralston, Robin A.
Thomas-Ahner, Jennifer M.
Schwartz, Steven J.
Clinton, Steven K.
Mortazavi, Amir
Publication Title: 
ACS nano

Semiconductor quantum dots (Qdots) are a promising new technology with benefits in the areas of medical diagnostics and therapeutics. Qdots generally consist of a semiconductor core, capping shell, and surface coating. The semiconductor core of Qdots is often composed of group II and VI metals (e.g., Cd, Se, Te, Hg) that are known to have toxic properties. Various surface coatings have been shown to stabilize Qdots and thus shield cells from the toxic properties of their core elements.

Smith, Wesley E.
Brownell, Jessica
White, Collin C.
Afsharinejad, Zahra
Tsai, Jesse
Hu, Xiaoge
Polyak, Stephen J.
Gao, Xiaohu
Kavanagh, Terrance J.
Eaton, David L.
Publication Title: 
ACS nano

Gold and copper nanoparticles have been widely investigated for photothermal therapy of cancer. However, degradability and toxicity of these nanoparticles remain concerns. Here, we compare hollow CuS nanoparticles (HCuSNPs) with hollow gold nanospheres (HAuNS) in similar particle sizes and morphology following intravenous administration to mice. The injected pegylated HCuSNPs (PEG-HCuSNPs) are eliminated through both hepatobiliary (67 percentage of injected dose, %ID) and renal (23 %ID) excretion within one month postinjection.

Guo, Liangran
Panderi, Irene
Yan, Daisy D.
Szulak, Kevin
Li, Yajuan
Chen, Yi-Tzai
Ma, Hang
Niesen, Daniel B.
Seeram, Navindra
Ahmed, Aftab
Yan, Bingfang
Pantazatos, Dionysios
Lu, Wei
Publication Title: 
Journal of Agricultural and Food Chemistry

Increased consumption of cruciferous vegetables such as broccoli may reduce the risk of various cancers. Myrosinase is required to convert dietary glucosinolates from broccoli into bioactive isothiocyanates. We evaluated isothiocyanate excretion profiles in healthy subjects who consumed broccoli sprouts or broccoli supplement (no myrosinase) with equivalent glucosinolate content. Urinary metabolites of two major isothiocyanates, sulforaphane and erucin, were measured by liquid chromatography coupled with tandem mass spectrometry.

Clarke, John D.
Riedl, Ken
Bella, Deborah
Schwartz, Steven J.
Stevens, Jan F.
Ho, Emily


Subscribe to RSS - Sulfides