Sulfones

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Low-back pain is a common condition and a substantial economic burden in industrialized societies. A large proportion of patients with chronic low-back pain use complementary and alternative medicine (CAM), visit CAM practitioners, or both. Several herbal medicines have been purported for use in low-back pain. OBJECTIVES: To determine the effectiveness of herbal medicine for non-specific low-back pain.

Author(s): 
Gagnier, J. J.
van Tulder, M.
Berman, B.
Bombardier, C.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Samuel Hahnemann attributed fundamental importance to the principle of similitude, promoting it to a 'natural law'. Observing that enantiopathic or allopathic treatment produced enduring aggravation of the disease symptoms after a brief and transitory initial relief, he systematised homeopathic treatment, prescribing substances that provoke similar symptoms in healthy individual.

Author(s): 
Teixeira, M. Z.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Low-back pain (LBP) is a common condition and imposes a substantial economic burden upon people living in industrialized societies. A large proportion of people with chronic LBP use complementary and alternative medicine (CAM), visit CAM practitioners, or both. Several herbal medicines have been purported for use in treating people with LBP. This is an update of a Cochrane Review first published in 2006. OBJECTIVES: To determine the effectiveness of herbal medicine for non-specific LBP.

Author(s): 
Oltean, Hanna
Robbins, Chris
van Tulder, Maurits W.
Berman, Brian M.
Bombardier, Claire
Gagnier, Joel J.
Publication Title: 
Spine

STUDY DESIGN: A randomized controlled clinical trial was conducted. OBJECTIVE: To compare medication, needle acupuncture, and spinal manipulation for managing chronic (>13 weeks duration) spinal pain because the value of medicinal and popular forms of alternative care for chronic spinal pain syndromes is uncertain. SUMMARY OF BACKGROUND DATA: Between February 1999 and October 2001, 115 patients without contraindication for the three treatment regimens were enrolled at the public hospital's multidisciplinary spinal pain unit.

Author(s): 
Giles, Lynton G. F.
Muller, Reinhold
Publication Title: 
Spine

STUDY DESIGN: A randomized controlled clinical trial was conducted. OBJECTIVE: To compare medication, needle acupuncture, and spinal manipulation for managing chronic (>13 weeks duration) spinal pain because the value of medicinal and popular forms of alternative care for chronic spinal pain syndromes is uncertain. SUMMARY OF BACKGROUND DATA: Between February 1999 and October 2001, 115 patients without contraindication for the three treatment regimens were enrolled at the public hospital's multidisciplinary spinal pain unit.

Author(s): 
Giles, Lynton G. F.
Muller, Reinhold
Publication Title: 
Journal of Medicinal Chemistry

A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin in five or six chemical steps. One of these thermally and hydrolytically stable new chemical entities (4c) completely cured malaria-infected mice via a single oral dose of 144 mg/kg. At a much lower single oral dose of only 54 mg/kg combined with 13 mg/kg of mefloquine hydrochloride, this trioxane dimer 4c as well as its parent trioxane dimer 4b also completely cured malaria-infected mice. Both dimers 4c and 4b were potently and selectively cytotoxic toward five cancer cell lines.

Author(s): 
Rosenthal, Andrew S.
Chen, Xiaochun
Liu, Jun O.
West, Diana C.
Hergenrother, Paul J.
Shapiro, Theresa A.
Posner, Gary H.
Publication Title: 
Bioorganic & Medicinal Chemistry Letters

A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range.

Author(s): 
Capela, Rita
Oliveira, Rudi
Gonçalves, Lídia M.
Domingos, Ana
Gut, Jiri
Rosenthal, Philip J.
Lopes, Francisca
Moreira, Rui
Publication Title: 
Journal of Medicinal Chemistry

Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.

Author(s): 
Slack, Rachel D.
Mott, Bryan T.
Woodard, Lauren E.
Tripathi, Abhai
Triphati, Abhai
Sullivan, David
Nenortas, Elizabeth
Girdwood, Sonya C. T.
Shapiro, Theresa A.
Posner, Gary H.
Publication Title: 
Methods and Findings in Experimental and Clinical Pharmacology

Curcumin is a yellow-colored plant polyphenol with a long history of medicinal use in ayurvedic, Chinese and Japanese medicine. Studies have reported the cyclooxygenase COX-2-inhibitory activity of this polyphenol; however, none of the studies have established its antiinflammatory activity in the rat cotton pellet granuloma pouch model, which mimics subchronic inflammation in humans. The present study was conducted to evaluate the effect of curcumin in the cotton pellet granuloma pouch model.

Author(s): 
Nandal, Shivender
Dhir, Ashish
Kuhad, Anurag
Sharma, Sameer
Chopra, Kanwaljit
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Ayurvedic/herbal healthcare products are considered safe under the impression that they are derived from natural products. But recently, there have been several reports worldwide on the adulteration of synthetic PDE-5 inhibitors in aphrodisiac herbal formulations. Therefore, the objective of the present study was to explore the presence of synthetic PDE-5 inhibitors (sildenafil, tadalafil and/or vardenafil) in ayurvedic/herbal healthcare products sold in Indian market for aphrodisiac/related uses. In total, 85 herbal formulations (HFs) were included in the study.

Author(s): 
Savaliya, Akash A.
Shah, Ravi P.
Prasad, Bhagwat
Singh, Saranjit

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