Sulfonic Acids

Publication Title: 
Drugs Under Experimental and Clinical Research

Allergic rhinitis, a frequently occurring immunological disorder affecting men, women and children worldwide, is a state of hypersensitivity that occurs when the body overreacts to a substance such as pollen, mold, mites or dust. Allergic rhinitis exerts inflammatory response and irritation of the nasal mucosal membranes leading to sneezing; stuffy/runny nose; nasal congestion; and itchy, watery and swollen eyes.

Author(s): 
D'Souza, P.
Amit, A.
Saxena, V. S.
Bagchi, D.
Bagchi, M.
Stohs, S. J.
Publication Title: 
Medicinal Chemistry (Shariqah (United Arab Emirates))

Ethanolic extracts of 30 Thai medicinal plants, traditionally used as alternative treatments in diabetes, were evaluated for antioxidative activity by the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method. They were evaluated in vitro for oxidative stress by thiobarbituric acid-reactive substance (TBARS) assay in pooled plasma of diabetic patients compared to without treatment of the extracts (control). The extracts were also assayed for protein glycation. The results showed that five plants had strong antioxidant activity: Phyllanthus emblica Linn.

Author(s): 
Kusirisin, W.
Srichairatanakool, S.
Lerttrakarnnon, P.
Lailerd, N.
Suttajit, M.
Jaikang, C.
Chaiyasut, C.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS: The evaluation of enzyme inhibitory activity of seven Australian aboriginal medicinal plants and five Indian Ayurvedic plants was carried out against α-amylase and α-glucosidase.

Author(s): 
Gulati, Vandana
Harding, Ian H.
Palombo, Enzo A.
Publication Title: 
Journal of Ethnopharmacology

A number of Indian medicinal plants have been used for thousands of years in the traditional system of medicine (Ayurveda). Amongst these are plants used for the management of neurodegenerative diseases such as Parkinson's, Alzheimer's, loss of memory, degeneration of nerves and other neuronal disorders by the Ayurvedic practitioners. Though the etiology of neurodegenerative diseases remains enigmatic, there is evidence, which indicates that defective energy metabolism, excitotoxicity and oxidative damage may be crucial factors (Ann. Neurol. 38 (3) (1995) 357).

Author(s): 
Auddy, B.
Ferreira, M.
Blasina, F.
Lafon, L.
Arredondo, F.
Dajas, F.
Tripathi, P. C.
Seal, T.
Mukherjee, B.
Publication Title: 
Phytotherapy research: PTR

Hydnocarpus wightiana is advocated in traditional Indian medicine to possess strong antidiabetic activity. In the course of identifying bioactive fractions from Indian medicinal plants we observed that acetone extract of the seed hulls of H. wightiana possess strong free radicals (DPPH and ABTS) scavenging, alpha-glucosidase and moderate N-acetyl-beta-D-glucosaminidase inhibitory activities. Further fractionation of the extract led to the isolation of hydnocarpin, luteolin and isohydnocarpin in substantial yields. All the compounds showed strong ABTS scavenging property.

Author(s): 
Reddy, S. Venkat
Tiwari, Ashok K.
Kumar, U. Sampath
Rao, R. Jagadeeshwar
Rao, J. Madhusudan
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS: The evaluation of enzyme inhibitory activity of seven Australian aboriginal medicinal plants and five Indian Ayurvedic plants was carried out against α-amylase and α-glucosidase.

Author(s): 
Gulati, Vandana
Harding, Ian H.
Palombo, Enzo A.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

The UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) represent major phase II drug-metabolizing enzymes that are also responsible for maintaining cellular homeostasis by metabolism of several endogenous molecules. Perturbations in the expression or function of these enzymes can lead to metabolic disorders and improper management of xenobiotics and endobiotics. Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver damage ranging from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis.

Author(s): 
Hardwick, Rhiannon N.
Ferreira, Daniel W.
More, Vijay R.
Lake, April D.
Lu, Zhenqiang
Manautou, Jose E.
Slitt, Angela L.
Cherrington, Nathan J.
Publication Title: 
Molecules (Basel, Switzerland)

Rhizoma Atractylodes macrocephala (AM) has been used in Traditional Chinese Medicine (TCM) for about 2,000 years. In the study, we firstly determined the antioxidant levels of five AM extracts by •OH-scavenging, •O2−-scavenging, Fe2+-chelating, Cu2+-chelating, DPPH·-scavenging, and ABTS+·-scavenging assays. After measurement of the chemical contents in five AM extracts, we quantitatively analyzed the correlations between antioxidant levels and chemical contents.

Author(s): 
Li, Xican
Lin, Jian
Han, Weijuan
Mai, Wenqiong
Wang, Li
Li, Qiang
Lin, Miaofang
Bai, Mingsong
Zhang, Lishan
Chen, Dongfeng
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