Sulfotransferases

Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Curcuminoid extract and piperine are being evaluated for beneficial effects in Alzheimer's disease, among other intractable disorders. Consequently, we studied the potential for herb-drug interactions involving cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes. The curcuminoid extract inhibited SULT > CYP2C19 > CYP2B6 > UGT > CYP2C9 > CYP3A activities with IC(50) values ranging from 0.99 +/- 0.04 to 25.3 +/- 1.3 microM, whereas CYP2D6, CYP1A2, and CYP2E1 activities were less affected (IC(50) values > 60 microM).

Author(s): 
Volak, Laurie P.
Ghirmai, Senait
Cashman, John R.
Court, Michael H.
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Bamboo leaves are used as a component in traditional Chinese medicine for the anti-inflammatory function. Our previous studies have demonstrated that an ethanol/water extract from Phyllostachys edulis ameliorated obesity-associated chronic systemic inflammation in mice, and therefore relieving the symptoms of type 2 diabetes.

Author(s): 
Koide, Cheryl L. K.
Collier, Abby C.
Berry, Marla J.
Panee, Jun
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

The UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) represent major phase II drug-metabolizing enzymes that are also responsible for maintaining cellular homeostasis by metabolism of several endogenous molecules. Perturbations in the expression or function of these enzymes can lead to metabolic disorders and improper management of xenobiotics and endobiotics. Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver damage ranging from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis.

Author(s): 
Hardwick, Rhiannon N.
Ferreira, Daniel W.
More, Vijay R.
Lake, April D.
Lu, Zhenqiang
Manautou, Jose E.
Slitt, Angela L.
Cherrington, Nathan J.
Publication Title: 
Biological & Pharmaceutical Bulletin

Sulfotransferase 1A3 (SULT1A3) is a phase II detoxifying enzyme of xenobiotics predominantly expressed in the intestinal epithelium. Recent increase in the use of herbal extracts as dietary supplements may lead to an increase in the possibility of dietary supplement-drug interactions. The purpose of the present study was to investigate the effects of 18 herbal extracts on SULT1A3 activity and the possibility of interaction between medicinal drugs and herbal extracts.

Author(s): 
Nagai, Marie
Fukamachi, Takahiro
Tsujimoto, Masayuki
Ogura, Kenichiro
Hiratsuka, Akira
Ohtani, Hisakazu
Hori, Satoko
Sawada, Yasufumi
Publication Title: 
Journal of Lipid Research

Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. However, relatively less is known regarding its role in neurological functions. Using shotgun lipidomics, we investigated the lipidome of mouse cerebral cortex with generalized deficiency of PGC-1α (PGC-1α(-/-)) versus wild-type (WT) mice under standard diet and chronically calorically restricted conditions.

Author(s): 
Kiebish, Michael A.
Young, Dee M.
Lehman, John J.
Han, Xianlin
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Bamboo leaves are used as a component in traditional Chinese medicine for the anti-inflammatory function. Our previous studies have demonstrated that an ethanol/water extract from Phyllostachys edulis ameliorated obesity-associated chronic systemic inflammation in mice, and therefore relieving the symptoms of type 2 diabetes.

Author(s): 
Koide, Cheryl L. K.
Collier, Abby C.
Berry, Marla J.
Panee, Jun
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