Swertia chirata

Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-? has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
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