Synovial Membrane

Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVE: This study evaluates the anti-arthritic effect of Terminalia chebula hydroalcoholic extract (TCHE) in experimental models and attempts to correlate the effect of treatment on macrophage-derived pro-inflammatory cytokine expression and extent of disease activity. METHODS: Arthritis was induced in rats by subplantar administration of either formaldehyde or complete Freund's adjuvant (CFA). Joint size was measured at regular intervals by using a micrometer screw gauge.

Author(s): 
Nair, Vinod
Singh, Surender
Gupta, Yogendra Kumar
Publication Title: 
Arthritis Research & Therapy

INTRODUCTION: B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be elucidated, repetitive treatment with B-cell-depleting agents leading to long-term B-cell depletion has been reported to be beneficial. The latter has led to the hypothesis that the beneficial effects of B-cell depletion might act through their influence on pathogenic autoreactive plasma cells.

Author(s): 
Teng, Y. K. Onno
Wheater, Gillian
Hogan, Vanessa E.
Stocks, Philip
Levarht, E. W. Nivine
Huizinga, Tom W. J.
Toes, Rene E. M.
van Laar, Jacob M.
Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVES: Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and further investigated the signal mechanism by which this compound modulates those cytokines' production.

Author(s): 
Xu, H.
He, Y.
Yang, X.
Liang, L.
Zhan, Z.
Ye, Y.
Yang, X.
Lian, F.
Sun, L.
Publication Title: 
BMC research notes

BACKGROUND: Salacia reticulata (SR) is a plant native to Sri Lanka. In ayurvedic medicine, SR bark preparations, taken orally, are considered effective in the treatment of rheumatism and diabetes. We investigated the ability of SR leaves (SRL) to inhibit in vitro the interleukin-1β (IL-1β)-activated proliferation of synoviocyte-like cells derived from rheumatoid arthritis model mice. FINDINGS: Inflammatory synovial tissues were harvested from type II collagen antibody-induced arthritic mice. From these tissues, a synoviocyte-like cell line was established and named MTS-C H7.

Author(s): 
Sekiguchi, Yuusuke
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Kobata, Kenji
Wada, Masahiro
Publication Title: 
BMC research notes

BACKGROUND: Salacia reticulata (SR) is a plant native to Sri Lanka. In ayurvedic medicine, SR bark preparations, taken orally, are considered effective in the treatment of rheumatism and diabetes. We investigated the ability of SR leaves (SRL) to inhibit in vitro the interleukin-1β (IL-1β)-activated proliferation of synoviocyte-like cells derived from rheumatoid arthritis model mice. FINDINGS: Inflammatory synovial tissues were harvested from type II collagen antibody-induced arthritic mice. From these tissues, a synoviocyte-like cell line was established and named MTS-C H7.

Author(s): 
Sekiguchi, Yuusuke
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Kobata, Kenji
Wada, Masahiro
Publication Title: 
Annals of the Rheumatic Diseases

OBJECTIVE: To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA). METHODS: Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). In the first study, rabbits (six in each group) received intramuscular injections of GlcNAc or normal saline three times a week starting 1 week postoperatively. In the second study, rabbits (eight in each group) were injected intra-articularly with GlcNAc (either once or twice a week) or normal saline.

Author(s): 
Shikhman, A. R.
Amiel, D.
D'Lima, D.
Hwang, S.-B.
Hu, C.
Xu, A.
Hashimoto, S.
Kobayashi, K.
Sasho, T.
Lotz, M. K.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

In common with many other cell types, synovial fibroblasts produce exosomes. In this study, we show that the exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis (RASF), but not exosomes produced by synovial fibroblasts obtained from individuals with osteoarthritis, contain a membrane bound form of TNF-alpha as demonstrated by colloidal gold immunostaining of TNF-alpha and confirmed by both Western blot and mass spectrometry.

Author(s): 
Zhang, Huang-Ge
Liu, Cunren
Su, Kaihong
Su, Kaihun
Yu, Shaohua
Zhang, Liming
Zhang, Shuangqin
Wang, Jianhua
Cao, Xu
Grizzle, William
Kimberly, Robert P.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Excess iron may increase oxidative stress and play a role in vascular inflammation and atherosclerosis. Here we determined whether the iron chelator, desferrioxamine (DFO), ameliorates oxidative stress and cellular adhesion molecule expression in a murine model of local inflammation. METHODS AND RESULTS: Dorsal air pouches were created in C57BL/6J mice by subcutaneous injection of air. DFO (100 mg/kg body weight) was injected into the air pouch once a day for two days followed immediately on the second day by lipopolysaccharide (LPS; 2.5 mg/kg body weight).

Author(s): 
Li, Lixin
Frei, Balz
Publication Title: 
Arthritis Research & Therapy

Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However, the mechanisms of action of these agents are not fully defined. Using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis, we determined whether the ethanol extract of Celastrus aculeatus Merr. (Celastrus), a Chinese herb, can down-modulate the severity of AA, and also examined the Celastrus-induced changes in immune responses to the disease-related antigen mycobacterial heat-shock protein 65 (Bhsp65).

Author(s): 
Tong, Li
Moudgil, Kamal D.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Regulation of IL-6 transsignaling by the administration of soluble gp130 (sgp130) receptor to capture the IL-6/soluble IL-6R complex has shown promise for the treatment of rheumatoid arthritis (RA). However, enhancing endogenous sgp130 via alternative splicing of the gp130 gene has not yet been tested. We found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1beta-induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production.

Author(s): 
Ahmed, Salahuddin
Marotte, Hubert
Kwan, Kevin
Ruth, Jeffrey H.
Campbell, Phillip L.
Rabquer, Bradley J.
Pakozdi, Angela
Koch, Alisa E.

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