Systems Biology

Publication Title: 
Artificial Intelligence in Medicine

OBJECTIVE: Traditional Chinese medicine (TCM) is a scientific discipline, which develops the related theories from the long-term clinical practices. The large-scale clinical data are the core empirical knowledge source for TCM research. This paper introduces a clinical data warehouse (CDW) system, which incorporates the structured electronic medical record (SEMR) data for medical knowledge discovery and TCM clinical decision support (CDS).

Author(s): 
Zhou, Xuezhong
Chen, Shibo
Liu, Baoyan
Zhang, Runsun
Wang, Yinghui
Li, Ping
Guo, Yufeng
Zhang, Hua
Gao, Zhuye
Yan, Xiufeng
Publication Title: 
Gerontology

A fundamental impact of mitochondria on biological aging has been suggested decades ago. One prominent theory explains aging as the result of the age-related accumulation of random molecular damage of biomolecules resulting from the reaction of reactive oxygen species, the majority of which are generated in mitochondria. Although this concept appeared to be very attractive and strongly influenced aging research, in recent years more and more data accumulated which seem to contradict this theory.

Author(s): 
Osiewacz, Heinz D.
Bernhardt, Dominik
Publication Title: 
PLoS genetics

Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests the involvement of fundamental mechanisms, although these remain a subject of debate. To help decipher the life-extending mechanisms of DR, we first compiled a list of genes that if genetically altered disrupt or prevent the life-extending effects of DR. We called these DR-essential genes and identified more than 100 in model organisms such as yeast, worms, flies, and mice.

Author(s): 
Wuttke, Daniel
Connor, Richard
Vora, Chintan
Craig, Thomas
Li, Yang
Wood, Shona
Vasieva, Olga
Shmookler Reis, Robert
Tang, Fusheng
de Magalh„es, Jo„o Pedro
Publication Title: 
Pharmacopsychiatry

The emerging research on biomarkers in alcohol dependence has lead to a deeper understanding of the neurobiological mechanisms in alcoholism. The molecular networks and the pathophysiological circuits are complex and not completely unrevealed up to now. One of the most interesting biomarkers described to play an important role in alcohol dependence is the amino-acid homocysteine, which has particularly been linked with brain atrophy and withdrawal seizures.

Author(s): 
Bleich, S.
Hillemacher, T.
Publication Title: 
Psychological Medicine

BACKGROUND: It has been well established that both genes and non-shared environment contribute substantially to the underlying aetiology of major depressive disorder (MDD). A comprehensive overview of genetic research in MDD is presented. Method Papers were retrieved from PubMed up to December 2011, using many keywords including: depression, major depressive disorder, genetics, rare variants, gene-environment, whole genome, epigenetics, and specific candidate genes and variants. These were combined in a variety of permutations.

Author(s): 
Cohen-Woods, S.
Craig, I. W.
McGuffin, P.
Publication Title: 
Advances in Child Development and Behavior

Several large-scale searches for genes that influence complex human traits, such as intelligence and personality, in the normal range of variation have failed to identify even one gene that makes a significant difference. All previously published claims for genetic influences of this kind now appear to have been false positives. For more serious psychiatric and medical disorders such as schizophrenia and autism, several genes have been found where a rare mutation contributes to abnormal behavior, but in many instances they are de novo mutations not obtained from a parent.

Author(s): 
Wahlsten, Douglas
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

The major psychiatric disorders are complex in nature, meaning that they are influenced by multiple environmental and genetic exposures that perturb the intricate cellular network, resulting in disease. In general, psychiatric diseases are highly heritable but also have important environmental etiologies. Environmental influences include neonatal exposures, social environments, psychological mechanisms, and abnormal functioning of the neurotransmitter system.

Author(s): 
Lasky-Su, Jessica
Publication Title: 
Pharmacology & Therapeutics

Despite intensive research over many years, the treatment of schizophrenia remains a major health issue. Current and emerging treatments for schizophrenia are based upon the classical dopamine and glutamate hypotheses of disease. Existing first and second generation antipsychotic drugs based upon the dopamine hypothesis are limited by their inability to treat all symptom domains and their undesirable side effect profiles. Third generation drugs based upon the glutamate hypothesis of disease are currently under evaluation but are more likely to be used as add on treatments.

Author(s): 
Winchester, Catherine L.
Pratt, Judith A.
Morris, Brian J.
Publication Title: 
Journal of Alzheimer's disease: JAD

Most forms of Alzheimer's disease (AD) are sporadic (sAD) or inherited in a non-Mendelian fashion, and less than 1% of cases are autosomal-dominant. Forms of sAD do not exhibit familial aggregation and are characterized by complex genetic and environmental interactions. Recently, the expansion of genomic methodologies, in association with substantially larger combined cohorts, has resulted in various genome-wide association studies that have identified several novel genetic associations of AD.

Author(s): 
Lista, Simone
O'Bryant, Sid E.
Blennow, Kaj
Dubois, Bruno
Hugon, Jacques
Zetterberg, Henrik
Hampel, Harald
Publication Title: 
Journal of Translational Medicine

Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost physical, mental, social and spiritual harmony and improve quality of life. Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects.

Author(s): 
Deocaris, Custer C.
Widodo, Nashi
Wadhwa, Renu
Kaul, Sunil C.

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