Systems Integration

Publication Title: 
Artificial Intelligence in Medicine

OBJECTIVE: Traditional Chinese medicine (TCM) is a scientific discipline, which develops the related theories from the long-term clinical practices. The large-scale clinical data are the core empirical knowledge source for TCM research. This paper introduces a clinical data warehouse (CDW) system, which incorporates the structured electronic medical record (SEMR) data for medical knowledge discovery and TCM clinical decision support (CDS).

Author(s): 
Zhou, Xuezhong
Chen, Shibo
Liu, Baoyan
Zhang, Runsun
Wang, Yinghui
Li, Ping
Guo, Yufeng
Zhang, Hua
Gao, Zhuye
Yan, Xiufeng
Publication Title: 
Medical Hypotheses

A synergistic-healing strategy that combines molecular targeting within a system-wide perspective is presented as the Multiple Integrated Complementary Healing Approaches: Energetics And Light (MICHAEL). The basis of the MICHAEL approach is the realization that environmental, nutritional and electromagnetic factors form a regulatory framework involved in bone and nerve healing. The interactions of light, energy, and nutrition with neural, hormonal and cellular pathways will be presented.

Author(s): 
Gray, Michael G.
Lackey, Brett R.
Patrick, Evelyn F.
Gray, Sandra L.
Hurley, Susan G.
Publication Title: 
Nucleic Acids Research

The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing.

Author(s): 
Tacutu, Robi
Craig, Thomas
Budovsky, Arie
Wuttke, Daniel
Lehmann, Gilad
Taranukha, Dmitri
Costa, Joana
Fraifeld, Vadim E.
de Magalh„es, Jo„o Pedro
Publication Title: 
Nucleic Acids Research

The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing.

Author(s): 
Tacutu, Robi
Craig, Thomas
Budovsky, Arie
Wuttke, Daniel
Lehmann, Gilad
Taranukha, Dmitri
Costa, Joana
Fraifeld, Vadim E.
de Magalh„es, Jo„o Pedro
Publication Title: 
Medical Hypotheses

Although chronic low back pain (cLBP) is increasingly recognized as a complex syndrome with multifactorial etiology, the pathogenic mechanisms leading to the development of chronic pain in this condition remain poorly understood. This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural control, neuroplasticity).

Author(s): 
Langevin, Helene M.
Sherman, Karen J.
Publication Title: 
Medical Hypotheses

Although chronic low back pain (cLBP) is increasingly recognized as a complex syndrome with multifactorial etiology, the pathogenic mechanisms leading to the development of chronic pain in this condition remain poorly understood. This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural control, neuroplasticity).

Author(s): 
Langevin, Helene M.
Sherman, Karen J.
Publication Title: 
Medical Hypotheses

Although chronic low back pain (cLBP) is increasingly recognized as a complex syndrome with multifactorial etiology, the pathogenic mechanisms leading to the development of chronic pain in this condition remain poorly understood. This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural control, neuroplasticity).

Author(s): 
Langevin, Helene M.
Sherman, Karen J.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

Enlightened by the idea of correlation of mind and body in traditional Chinese medicine and western medicine, integrating his long-term clinical experience, the author brings forward a concise and practical theory for diagnosis and treatment based on the correlation between consciousness and organ in this article.

Author(s): 
Jia, Hai-Zhong
Publication Title: 
BMC bioinformatics

BACKGROUND: Recent advances in Web and information technologies with the increasing decentralization of organizational structures have resulted in massive amounts of information resources and domain-specific services in Traditional Chinese Medicine. The massive volume and diversity of information and services available have made it difficult to achieve seamless and interoperable e-Science for knowledge-intensive disciplines like TCM. Therefore, information integration and service coordination are two major challenges in e-Science for TCM.

Author(s): 
Chen, Huajun
Mao, Yuxin
Zheng, Xiaoqing
Cui, Meng
Feng, Yi
Deng, Shuiguang
Yin, Aining
Zhou, Chunying
Tang, Jinming
Jiang, Xiaohong
Wu, Zhaohui
Publication Title: 
Journal of Biomedical Informatics

As a form of important domain knowledge, large-scale ontologies play a critical role in building a large variety of knowledge-based systems. To overcome the problem of semantic heterogeneity and encode domain knowledge in reusable format, a large-scale and well-defined ontology is also required in the traditional Chinese medicine discipline. We argue that to meet the on-demand and scalability requirement ontology-based systems should go beyond the use of static ontology and be able to self-evolve and specialize for the domain knowledge they possess.

Author(s): 
Mao, Yuxin
Wu, Zhaohui
Tian, Wenya
Jiang, Xiaohong
Cheung, William K.

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