Technology, Pharmaceutical

Publication Title: 
Clinical Therapeutics

BACKGROUND: In view of the high rates of off-label and unlicensed prescribing of drugs in children, the US Food and Drug Administration and the European Union have implemented legislative regulations for the pharmaceutical industry to increase the number of drugs with approved pediatric labeling.

Author(s): 
van Riet-Nales, Diana A.
Schobben, Alfred F. A. M.
Egberts, Toine C. G.
Rademaker, Carin M. A.
Publication Title: 
Pakistan Journal of Pharmaceutical Sciences

The Ergh-al-Nassa pill (Hab) is a traditional combination suggested as one of the most effective preparations useful for treatment of sciatica. Although traditional preparations can be applied as new therapeutic drugs for investigations and clinical trials, they need to be reformulated to achieve pharmacopoeial standards for modern medicine. In this research, based on seven traditional Persian pharmacopeias for Ergh-al-NassaHab, nine different molded tablets were reformulated. Each formulation comprised the same amount of colchicum, ginger, aloe and yellow myrobalan fruit.

Author(s): 
Zargaran, Arman
Daneshamouz, Saeid
Kordafshari, Gholamreza
Mohagheghzadeh, Abdolali
Publication Title: 
Current Drug Targets

A significant increase of the elderly in populations of developed countries is followed by increase morbidity and mortality from main age-related diseases--cardiovascular and neuro-degenerative, cancer, diabetes mellitus, declining in a resistance to infections. Obviously, the development of means of the prevention of the premature ageing and these diseases in humans are crucial at present.

Author(s): 
Anisimov, Vladimir N.
Publication Title: 
The American Surgeon

The objective was to examine the economic, ethical, and legal foundations for conflict of interest restrictions between physicians and pharmaceutical and medical device industries ("industry"). Recently academic medical centers and professional organizations have adopted policies that restrict permissible interactions between industry and physicians. The motive is to avoid financial conflicts of interest that compromise core values of altruism and fiduciary relationships.

Author(s): 
Nakayama, Don K.
Publication Title: 
Cell

Traditional medicines provide fertile ground for modern drug development, but first they must pass along a pathway of discovery, isolation, and mechanistic studies before eventual deployment in the clinic. Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin.

Author(s): 
Corson, Timothy W.
Crews, Craig M.
Publication Title: 
AAPS PharmSciTech

The purpose of this research was to mask the intensely bitter taste of artemether (ARM) and to formulate a rapid-disintegrating tablet (RDT) of the taste-masked drug. Taste masking was done by solid dispersion with mono amino glycyrrhyzinate pentahydrate (GLY) by solvent evaporation method. To characterize and formulate taste masked rapid disintegrating tablets (RDTs) of ARM, the 1:1M solid dispersion was selected based on bitterness score.

Author(s): 
Shah, Punit P.
Mashru, Rajashree C.
Publication Title: 
Malaria Journal

BACKGROUND: Artemisinin-based fixed dose combination (FDC) products are recommended by World Health Organization (WHO) as a first-line treatment. However, the current artemisinin FDC products, such as ?-artemether and lumefantrine, are inherently unstable and require controlled distribution and storage conditions, which are not always available in resource-limited settings. Moreover, quality control is hampered by lack of suitable analytical methods.

Author(s): 
Suleman, Sultan
Vandercruyssen, Kirsten
Wynendaele, Evelien
D'Hondt, Matthias
Bracke, Nathalie
Duchateau, Luc
Burvenich, Christian
Peremans, Kathelijne
De Spiegeleer, Bart
Publication Title: 
International Journal of Pharmaceutics

Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against both malaria and bacterial infections. Analytical and pharmacotechnical development, followed by in vitro and in vivo evaluation, were conducted for various AMAZ coformulations.

Author(s): 
Gaubert, Alexandra
Kauss, Tina
Marchivie, Mathieu
Ba, Boubakar B.
Lembege, Martine
Fawaz, Fawaz
Boiron, Jean-Michel
Lafarge, Xavier
Lindegardh, Niklas
Fabre, Jean-Louis
White, Nicholas J.
Olliaro, Piero L.
Millet, Pascal
Grislain, Luc
Gaudin, Karen
Publication Title: 
Acta Poloniae Pharmaceutica

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due to poor dissolution characteristics in the intestinal fluids. To enhance these properties, solid dispersions of artemisinin with succinic acid (SUC) were prepared using drug-carrier ratios 1 : 1, 1 : 4, 1 : 6, 1 : 8 and 1 : 10 by solvent evaporation and freeze drying methods.

Author(s): 
Ansari, Muhammad Tayyab
Pervez, Humayun
Shehzad, Muhammad Tariq
Saeed-ul-Hassan, Syed
Mehmood, Zahid
Shah, Syed Nisar Hussain
Razi, Muhammad Tahir
Murtaza, Ghulam
Publication Title: 
Zhong Yao Tong Bao (Beijing, China: 1981)
Author(s): 
Tu, Y. Y.

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