Telomerase

Publication Title: 
Journal of Cancer Research and Clinical Oncology

PURPOSE: We performed a case-control study in which we tested the ability of a non-invasive assay to detect telomerase activity and to distinguish between prostatic cancer (Pca) and benign prostatic hyperplasia (BPH) on samples of epithelial cells obtained after prostatic massage. METHODS: Telomerase activity was determined by a telomeric repeat amplification protocol (TRAP) assay. We selected 60 patients with histologically proven Pca (30 cases) or BPH (30 cases).

Author(s): 
Vicentini, Carlo
Gravina, Giovanni Luca
Angelucci, Adriano
Pascale, Esterina
D'Ambrosio, Ettore
Muzi, Paola
Di Leonardo, Gabriella
Fileni, Antonio
Tubaro, Andrea
Festuccia, Claudio
Bologna, Mauro
Publication Title: 
Rejuvenation Research

Most human cells lack sufficient telomerase to maintain telomeres, hence these genetic elements shorten with time and stress, contributing to aging and disease. In January, 2007, a commercial health maintenance program, PattonProtocol-1, was launched that included a natural product-derived telomerase activator (TA-65®, 10-50 mg daily), a comprehensive dietary supplement pack, and physician counseling/laboratory tests at baseline and every 3-6 months thereafter. We report here analysis of the first year of data focusing on the immune system.

Author(s): 
Harley, Calvin B.
Liu, Weimin
Blasco, Maria
Vera, Elsa
Andrews, William H.
Briggs, Laura A.
Raffaele, Joseph M.
Publication Title: 
Rejuvenation Research

Most human cells lack sufficient telomerase to maintain telomeres, hence these genetic elements shorten with time and stress, contributing to aging and disease. In January, 2007, a commercial health maintenance program, PattonProtocol-1, was launched that included a natural product-derived telomerase activator (TA-65®, 10-50 mg daily), a comprehensive dietary supplement pack, and physician counseling/laboratory tests at baseline and every 3-6 months thereafter. We report here analysis of the first year of data focusing on the immune system.

Author(s): 
Harley, Calvin B.
Liu, Weimin
Blasco, Maria
Vera, Elsa
Andrews, William H.
Briggs, Laura A.
Raffaele, Joseph M.
Publication Title: 
FEBS letters

Caloric restriction (CR) is known to effectively elongate mammalian life-spans. The compound 2-deoxy-D-glucose (2DG), which is often used as an inhibitor of glucose utilization, is a mimetic agent of CR. In this study, we examined the changes of telomerase and Werner's syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres. Interestingly, 2DG treatment increased the expression of WRN protein in accordance with induction of its promoter activity and gene expression.

Author(s): 
Zhou, Bei
Ikejima, Takashi
Watanabe, Takeshi
Iwakoshi, Keiko
Idei, Yohei
Tanuma, Sei-ichi
Uchiumi, Fumiaki
Publication Title: 
Aging Cell

In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive oxygen species (ROS) and bioactive peptides including pro-inflammatory cytokines. This makes senescent cells a potential cause of tissue functional decline in aging. To our knowledge, we show here for the first time evidence suggesting that DNA damage induces a senescence-like state in mature postmitotic neurons in vivo.

Author(s): 
Jurk, Diana
Wang, Chunfang
Miwa, Satomi
Maddick, Mandy
Korolchuk, Viktor
Tsolou, Avgi
Gonos, Efstathios S.
Thrasivoulou, Christopher
Saffrey, M. Jill
Cameron, Kerry
von Zglinicki, Thomas
Publication Title: 
PloS One

Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background.

Author(s): 
Vera, Elsa
Bernardes de Jesus, Bruno
Foronda, Miguel
Flores, Juana M.
Blasco, Maria A.
Publication Title: 
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

OBJECTIVE: To observe the effects of classical traditional Chinese medicine prescriptions that function to promote blood circulation and removing blood stasis on the metastatic behavior of malignant tumors, and explore the possible mechanisms of such effects.

Author(s): 
Wang, Cheng
Yang, Yun-Gao
Wang, Xue-Liang
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To observe the effects of Shoushen Granule, a compound traditional Chinese herbal medicine, on telomere length and telomerase activity in peripheral leukocytes and vascular cells, artery wall lesions and blood lipid in a Sprague-Dawley (SD) rat model of atherosclerosis. METHODS: Forty SD rats were randomly divided into normal control group, model group, Shoushen Granule group and Western medicine group with 10 in each group. The rat model of atherosclerosis was established by high-fat diet and vitamin D3 loading.

Author(s): 
Chen, Chuan
Chi, Hui-ying
Yu, Zhi-hua
Chen, Jiu-lin
Publication Title: 
Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine

BACKGROUND: Chronic fatigue is common in the general population. Complementary therapies are often used by patients with chronic fatigue or chronic fatigue syndrome to manage their symptoms. PURPOSE: This study aimed to assess the effect of a 4-month qigong intervention program among patients with chronic fatigue or chronic fatigue syndrome. METHODS: Sixty-four participants were randomly assigned to either an intervention group or a wait list control group. Outcome measures included fatigue symptoms, physical functioning, mental functioning, and telomerase activity.

Author(s): 
Ho, Rainbow T. H.
Chan, Jessie S. M.
Wang, Chong-Wen
Lau, Benson W. M.
So, Kwok Fai
Yuen, Li Ping
Sham, Jonathan S. T.
Chan, Cecilia L. W.

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