The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels. No significant differences of the promoter DNA methylation within a control gene (presenilin-1) in alcoholics and controls were found.
This study is a secondary analysis of a randomized controlled trial that tested the effects of a gratitude intervention on well-being in a sample of individuals in outpatient treatment for alcohol use disorder (AUD). Follow-up qualitative interviews unexpectedly revealed that participants found the Positive and Negative Affect Schedule (PANAS) to be helpful to their recovery in the ways that it asked them to identify and rate their emotions.
AIM: To compare Five-Factor personality traits in patients maintaining abstinence and relapsed patients (i.e. those who relapsed within a year after treatment), following eight weeks of in-house treatment and three months of out-patient treatment. METHOD: In longitudinal studies, a sample of 190 patients was analysed (49 females and 141 males; mean age: 43). The patients participated in therapeutic programmes at several addiction treatment centres across Poland.
The American Journal on Addictions / American Academy of Psychiatrists in Alcoholism and Addictions
A large proportion of patients treated for substance dependencies have attempted suicide. Scarce empirical evidence exists regarding their prognosis. Data from the Drug Abuse Treatment Outcome Survey were analyzed to determine the course of depression and substance dependence of 416 suicide attempters one year after discharge. The likelihood of recovery from drug dependence did not differ between patients who did or did not attempt suicide.
This article provides an introduction to the concept of shame as it relates to substance misuse. Empirical research on shame and addiction and the theoretical and operational definitions that underpin them are discussed. Potential areas of further inquiry are highlighted. Implications for clinical practice are discussed.
Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Although continuing care is strongly related to positive treatment outcomes for substance use disorder (SUD), participation rates are low and few effective interventions are available. In a randomized clinical trial with 150 participants (97% men), 75 graduates of a residential Veterans Affairs Medical Center SUD program who received an aftercare contract, attendance prompts, and reinforcers (CPR) were compared to 75 graduates who received standard treatment (STX). Among CPR participants, 55% completed at least 3 months of aftercare, compared to 36% in STX.