Terminalia chebula

Publication Title: 
Indian journal of clinical biochemistry: IJCB

Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2(nd) hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value.

Author(s): 
Murali, Y. K.
Chandra, Ramesh
Murthy, P. S.
Publication Title: 
Toxicology International

Experimental study was conducted to evaluate the hepato- and renoprotective effect of silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) toxicity in rats. Oral administration of APAP @ 500 mg/kg for 1 to 3 days to all the four groups (six rats in each) resulted in significant elevation of serum triglycerides, total cholesterol, blood urea nitrogen, serum creatinine, and aspartate transaminase activity. Post-treatment with silymarin @ 25 mg/kg and T.

Author(s): 
Gopi, K. S.
Reddy, A. Gopala
Jyothi, K.
Kumar, B. Anil
Publication Title: 
Iranian journal of pharmaceutical research: IJPR

The dried fruit of Terminalia chebula is widely used for its laxative properties. The objective of the present study was to examine the flowability and compressibility of Terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. Initial studies on flowability and compressibility revealed that the fruit powder flows poorly, is poorly compressible and mucilaginous in nature.

Author(s): 
Satya Prakash, Singh
Patra, Niranjan
Santanu, Chakraborty
Hemant Kumar, Pandit
Patro, Jagannath
Devi, Vimala
Publication Title: 
Iranian journal of pharmaceutical research: IJPR

Triphala is a traditional herbal formulation consisting of dried fruits originating from three medicinal plants, namely Terminalia chebula, Terminalia bellerica and Phyllanthus emblica. It is used in folk medicine for the treatment of headaches, dyspepsia and leucorrhoea. There are some reports regarding Triphala's pharmacological effects including its anti-cancer, radioprotective, hypocholesterolaemic, hepatoprotective and anti-oxidant activities. The most important components of these plants are the tannins and gallic acid which they contain.

Author(s): 
Vazirian, Mahdi
Khanavi, Mahnaz
Amanzadeh, Yaghoub
Hajimehdipoor, Homa
Publication Title: 
Iranian journal of pharmaceutical research: IJPR

The dried fruit of Terminalia chebula is widely used for its laxative properties. The objective of the present study was to examine the flowability and compressibility of Terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. Initial studies on flowability and compressibility revealed that the fruit powder flows poorly, is poorly compressible and mucilaginous in nature.

Author(s): 
Satya Prakash, Singh
Patra, Ch Niranjan
Santanu, Chakraborty
Hemant Kumar, Pandit
Patro, V. Jagannath
Devi, M. Vimala
Publication Title: 
Biomolecules & Therapeutics

The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease.

Author(s): 
Seo, Jong Bae
Jeong, Jae-Yeon
Park, Jae Young
Jun, Eun Mi
Lee, Sang-Ik
Choe, Sung Sik
Park, Do-Yang
Choi, Eun-Wook
Seen, Dong-Seung
Lim, Jong-Soon
Lee, Tae Gyu
Publication Title: 
International Journal of Molecular Sciences

In the present study, we firstly compared rat intestinal ?-glucosidase inhibitory activity by different ethanol-aqueous extractions from the dried fruits of Terminalia chebula Retz. The enzymatic assay showed that the 80% ethanol extract was more potent against maltase activity than both 50% and 100% ethanol extracts. By HPLC analysis, it was determined that the 80% ethanol extract had a higher content of chebulagic acid than each of 50% or 100% ethanol extract.

Author(s): 
Huang, Yi-Na
Zhao, Dong-Dong
Gao, Bo
Zhong, Kai
Zhu, Rui-Xue
Zhang, Yan
Xie, Wang-Jun
Jia, Li-Rong
Gao, Hong
Publication Title: 
Asian Pacific Journal of Tropical Biomedicine

Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. Terminalia chebula Retz. (Fam. Combretaceae), is called the 'King of Medicine' in Tibet and is always listed at the top of the list of 'Ayurvedic Materia Medica' because of its extraordinary power of healing. The whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human beings.

Author(s): 
Bag, Anwesa
Bhattacharyya, Subir Kumar
Chattopadhyay, Rabi Ranjan
Publication Title: 
Journal of Applied Microbiology

AIMS: In this study, an attempt has been made to isolate and identify the bioactive compounds from hydroalcoholic extract of Terminalia chebula fruits effective against multidrug-resistant uropathogens and also to elucidate the influence of metal ions on the growth inhibitory activity of isolated compounds against the studied bacteria, if any. METHODS AND RESULTS: Bioassay-guided fractionation and extensive spectrometric analyses (FT-IR, (1) H NMR, (13) C NMR and ESI-MS) were used to isolate and characterize the bioactive compound.

Author(s): 
Bag, A.
Bhattacharyya, S. K.
Chattopadhyay, R. R.
Publication Title: 
Ayu

Herbal remedies have a long history of use for gum and tooth problems such as dental caries. The present microbiological study was carried out to evaluate the antimicrobial efficacy of three medicinal plants (Terminalia chebula Retz., Clitoria ternatea Linn., and Wedelia chinensis (Osbeck.) Merr.) on three pathogenic microorganisms in the oral cavity (Streptococcus mutans, Lactobacillus casei, and Staphylococcus aureus). Aqueous extract concentrations (5%, 10%, 25%, and 50%) were prepared from the fruits of Terminalia chebula, flowers of Clitoria ternatea, and leaves of Wedelia chinensis.

Author(s): 
Pratap, Gowd M. J. S.
Manoj, Kumar M. G.
Sai, Shankar A. J.
Sujatha, B.
Sreedevi, E.

Pages

Subscribe to RSS - Terminalia chebula