Testis

Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

Our interest in development of hyaluronidase inhibitors as male antifertility agents led to identification of Terminalia chebula (T. chebula) plant with hyaluronidase (HAase) inhibitory activity of human spermatozoa ( approximately 93% inhibition) and rat caudal epididymal spermatozoa ( approximately 86% inhibition) in vitro at 30 mg/ml.

Author(s): 
Srivastav, Archana
Chandra, Abhishek
Singh, Madhulika
Jamal, Farrukh
Rastogi, Preeti
Rajendran, Siron Mani
Bansode, Falgun Wanganuji
Lakshmi, Vijai
Publication Title: 
The EMBO journal

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate lifespan extension both in budding yeast and worms. Here, we show that SIRT1, the human Sir2 homolog, is recruited to the promyelocytic leukemia protein (PML) nuclear bodies of mammalian cells upon overexpression of either PML or oncogenic Ras (Ha-rasV12). SIRT1 binds and deacetylates p53, a component of PML nuclear bodies, and it can repress p53-mediated transactivation.

Author(s): 
Langley, Emma
Pearson, Mark
Faretta, Mario
Bauer, Uta-Maria
Frye, Roy A.
Minucci, Saverio
Pelicci, Pier Giuseppe
Kouzarides, Tony
Publication Title: 
Disease Models & Mechanisms

The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the field of human telomere biology, the mouse has been used extensively as a model. However, there are fundamental differences between mouse and human cells. Therefore, additional models are required. In light of this, we have characterized telomerase-deficient zebrafish (Danio rerio) as the second vertebrate model for human telomerase-driven diseases.

Author(s): 
Anchelin, Monique
Alcaraz-PÈrez, Francisca
MartÌnez, Carlos M.
BernabÈ-GarcÌa, Manuel
Mulero, Victoriano
Cayuela, MarÌa L.
Publication Title: 
Regulatory toxicology and pharmacology: RTP

Ginger (Zingiber officinale Roscoe, Zingiberacae) is one of the most commonly used spices around the world and a traditional medicinal plant that has been widely used in Chinese, Ayurvedic and Unani-Tibb medicines for several thousand years. However, there was still lack of systemic safety evaluation. We conducted a 35-day toxicity study on ginger in rats. Both male and female rats were daily treated with ginger powder at the dosages of 500, 1000 and 2000 mg/kg body weight by a gavage method for 35 days.

Author(s): 
Rong, Xianglu
Peng, Gang
Suzuki, Takuya
Yang, Qinglin
Yamahara, Johji
Li, Yuhao
Publication Title: 
Regulatory toxicology and pharmacology: RTP

Ginger (Zingiber officinale Roscoe, Zingiberacae) is one of the most commonly used spices around the world and a traditional medicinal plant that has been widely used in Chinese, Ayurvedic and Unani-Tibb medicines for several thousand years. However, there was still lack of systemic safety evaluation. We conducted a 35-day toxicity study on ginger in rats. Both male and female rats were daily treated with ginger powder at the dosages of 500, 1000 and 2000 mg/kg body weight by a gavage method for 35 days.

Author(s): 
Rong, Xianglu
Peng, Gang
Suzuki, Takuya
Yang, Qinglin
Yamahara, Johji
Li, Yuhao
Publication Title: 
Environmental Toxicology and Pharmacology

Centella asiatica has been mentioned in ancient ayurvedic text of the Indian system of medicine for its properties to promote intelligence. The objective of the present study was to investigate the beneficial effects of C. asiatica on lead-induced oxidative stress and suppressed reproductive performance in male rats. Significant decrease in the weights of testes and epididymis were observed in lead treated animals.

Author(s): 
Sainath, S. B.
Meena, R.
Supriya, Ch
Reddy, K. Pratap
Reddy, P. Sreenivasula
Publication Title: 
Phytotherapy research: PTR

Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract. Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A.

Author(s): 
Sharma, Vikas
Boonen, Jente
Spiegeleer, Bart De
Dixit, V. K.
Publication Title: 
Biology of Reproduction

Although alcoholism causes changes in hepatic folate metabolism that are aggravated by folate deficiency, male reproductive effects have never been studied. We evaluated changes in folate metabolism in the male reproductive system following chronic ethanol consumption and folate deficiency. Twenty-four juvenile micropigs received folate-sufficient (FS) or folate-depleted (FD) diets or the same diets containing 40% of energy as ethanol (FSE or FDE) for 14 wk, and the differences between the groups were determined by ANOVA.

Author(s): 
Wallock-Montelius, Lynn M.
Villanueva, Jesus A.
Chapin, Robert E.
Conley, A. J.
Nguyen, Hung P.
Ames, Bruce N.
Halsted, Charles H.
Publication Title: 
Regulatory toxicology and pharmacology: RTP

Ginger (Zingiber officinale Roscoe, Zingiberacae) is one of the most commonly used spices around the world and a traditional medicinal plant that has been widely used in Chinese, Ayurvedic and Unani-Tibb medicines for several thousand years. However, there was still lack of systemic safety evaluation. We conducted a 35-day toxicity study on ginger in rats. Both male and female rats were daily treated with ginger powder at the dosages of 500, 1000 and 2000 mg/kg body weight by a gavage method for 35 days.

Author(s): 
Rong, Xianglu
Peng, Gang
Suzuki, Takuya
Yang, Qinglin
Yamahara, Johji
Li, Yuhao
Publication Title: 
JAMA
Author(s): 
Axelrad, S. D.

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