Publication Title: 
Mayo Clinic Proceedings

The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels.

Goldstein, Irwin
Kim, Noel N.
Clayton, Anita H.
DeRogatis, Leonard R.
Giraldi, Annamaria
Parish, Sharon J.
Pfaus, James
Simon, James A.
Kingsberg, Sheryl A.
Meston, Cindy
Stahl, Stephen M.
Wallen, Kim
Worsley, Roisin
Publication Title: 
The American Journal of Medicine

Recent studies have implicated elevated levels of serum estradiol in males as the major predisposing factor for myocardial infarction, with serum cholesterol playing a secondary role. The purpose of the present study was to investigate the effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet and daily exercise on levels of serum estradiol, testosterone, and lipids in males. Twenty-one males participating in the Pritikin Longevity Center 26-day residential program volunteered for the study.

Rosenthal, M. B.
Barnard, R. J.
Rose, D. P.
Inkeles, S.
Hall, J.
Pritikin, N.
Publication Title: 
Age (Dordrecht, Netherlands)

Calorie restriction (CR) slows aging and is thought to improve insulin sensitivity in laboratory animals. In contrast, decreased insulin signaling and/or mild insulin resistance paradoxically extends maximal lifespan in various genetic animal models of longevity. Nothing is known regarding the long-term effects of CR on glucose tolerance and insulin action in lean healthy humans.

Fontana, Luigi
Klein, Samuel
Holloszy, John O.
Publication Title: 
Aging Clinical and Experimental Research

BACKGROUND AND AIMS: Caloric restriction (CR) is the most robust and reproducible intervention for slowing aging, and maintaining health and vitality in animals. Previous studies found that CR is associated with changes in specific biomarkers in monkeys that were also associated with reduced risk of mortality in healthy men. In this study we examine the association between other potential biomarkers related to CR and extended lifespan in healthy humans.

Stenholm, Sari
Metter, E. Jeffrey
Roth, George S.
Ingram, Donald K.
Mattison, Julie A.
Taub, Dennis D.
Ferrucci, Luigi
Publication Title: 
Archives of Sexual Behavior

A multifaceted study was conducted to identify differences in biopsychosocial characteristics between a clinical group of 59 married women who complained of inhibited sexual desire (ISD) and 31 married women who expressed normal sexual desire (non-ISD). Areas of examination included personality, endocrine, relationship, and sexual dimensions. Instruments of data collection included the MMPI, Dyadic Adjustment Scale, radioimmunoassay of testosterone and prolactin levels, and a questionnaire which focused on demographic, relationship, and sexual information.

Stuart, F. M.
Hammond, D. C.
Pett, M. A.
Publication Title: 

In the medical evaluation of older female patients with sexual problems, you need to assess the woman's psychological state, as well as her physical condition. An important question to ask is whether her level of sexual activity is satisfactory to her. Women's early sexual experiences, in some cases including childhood sexual abuse, impact greatly on their sexuality in later life. When sexual problems are related to the menopause, customized hormone replacement therapy is the treatment of choice.

Butler, R. N.
Lewis, M. I.
Hoffman, E.
Whitehead, E. D.
Publication Title: 

To fall in love is the first step in pair formation in humans and is a complex process which only recently has become the object of neuroscientific investigation. The little information available in this field prompted us to measure the levels of some pituitary, adrenal and gonadal hormones in a group of 24 subjects of both sexes who had recently (within the previous six months) fallen in love, and to compare them with those of 24 subjects who were single or were part of a long-lasting relationship.

Marazziti, Donatella
Canale, Domenico
Publication Title: 
Journal of Personality and Social Psychology

Testosterone (T) appears to facilitate what biologists refer to as mating effort--the investment of time and energy into same-sex competition and mate-seeking behavior. Multiple studies show that men who are romantically involved (i.e., are paired) have lower T than single men, which may be due to a facultative adjustment by men of T levels in response to lower demands for mating effort.

McIntyre, Matthew
Gangestad, Steven W.
Gray, Peter B.
Chapman, Judith Flynn
Burnham, Terence C.
O'Rourke, Mary T.
Thornhill, Randy
Publication Title: 
American Journal of Human Biology: The Official Journal of the Human Biology Council

OBJECTIVES: The current study extends previous research on testosterone (T) and mating effort by examining whether relationship commitment and satisfaction explain variance in T beyond relationship status alone. METHODS: Salivary testosterone and self-reported assessments of relationship commitment and satisfaction were assessed among 90 heterosexual men and women (age M = 23.57) in a cross-sectional community sample.

Hooper, Ann E. Caldwell
Gangestad, Steven W.
Thompson, Melissa Emery
Bryan, Angela D.
Publication Title: 
Social Neuroscience

Early-stage romantic love involves reorganization of neurohormonal systems and behavioral patterns marked by mutual influences between the partners' physiology and behavior. Guided by the biobehavioral synchrony conceptual frame, we tested bidirectional influences between the partners' hormones and conflict behavior at the initiation of romantic love. Participants included 120 new lovers (60 couples) and 40 singles.

Schneiderman, Inna
Kanat-Maymon, Yaniv
Zagoory-Sharon, Orna
Feldman, Ruth


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