Tetrazolium Salts

Publication Title: 
Biological & Pharmaceutical Bulletin

The ripe fruit of Terminalia chebula RETZIUS (T. chebula RETZ) (Combretsceae), which is a native plant in India and Southeast Asia, has traditionally been used as a popular folk medicine for homeostatic, antitussive, laxative, diuretic, and cardiotonic treatments. The objective of this study was to evaluate the protective effects of an aqueous extract of fruit of T. chebula on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury observed in cultured rat primary hepatocytes and rat liver. Both treatment and pretreatment of the hepatocytes with the T.

Author(s): 
Lee, Hyun-Sun
Won, Nam Hee
Kim, Kyoung Heon
Lee, Hojoung
Jun, Woojin
Lee, Kwang-Won
Publication Title: 
Parasitology Research

The absence of a vaccine and the rampant resistance to almost all antimalarial drugs have accentuated the urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy. The aim of the study was to discover effective plant extracts against Plasmodium falciparum. In the present study, the hexane, chloroform, ethyl acetate, acetone, and methanol extracts of Citrus sinensis (peel), Leucas aspera, Ocimum sanctum, Phyllanthus acidus (leaf), Terminalia chebula (seed) were tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) strain of P.

Author(s): 
Bagavan, Asokan
Rahuman, Abdul Abdul
Kamaraj, Chinnaperumal
Kaushik, Naveen Kumar
Mohanakrishnan, Dinesh
Sahal, Dinkar
Publication Title: 
The Journal of Biological Chemistry

Artemisinin and its derivatives are currently recommended as first-line antimalarials in regions where Plasmodium falciparum is resistant to traditional drugs. The cytotoxic activity of these endoperoxides toward rapidly dividing human carcinoma cells and cell lines has been reported, and it is hypothesized that activation of the endoperoxide bridge by an iron(II) species, to form C-centered radicals, is essential for cytotoxicity.

Author(s): 
Mercer, Amy E.
Maggs, James L.
Sun, Xiao-Ming
Cohen, Gerald M.
Chadwick, James
O'Neill, Paul M.
Park, B. Kevin
Publication Title: 
PloS One

Artemether is the derivative extracted from Chinese traditional herb and originally used for malaria. Artemether also has potential therapeutic effects against tumors. Vascular cell adhesion molecule-1 (VCAM-1) is an important cell surface adhesion molecule associated with malignancy of gliomas. In this work, we investigated the role and mechanism of artemether combined with shRNA interference of VCAM-1 (shRNA-VCAM-1) on the migration, invasion and apoptosis of glioma cells.

Author(s): 
Wang, Ying-Bin
Hu, Yi
Li, Zhen
Wang, Ping
Xue, Yi-Xue
Yao, Yi-Long
Yu, Bo
Liu, Yun-Hui
Publication Title: 
PloS One

BACKGROUND AND PURPOSE: Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a steroid-backbone bound to a lactone or its derivatives. They are known to protect plants against herbivores and have medicinal value including anti-inflammation, anti-cancer, adaptogenic and anti-oxidant effects. Withaferin A (Wi-A) and Withanone (Wi-N) are two structurally similar withanolides isolated from Withania somnifera, also known as Ashwagandha in Indian Ayurvedic medicine.

Author(s): 
Vaishnavi, Kirti
Saxena, Nishant
Shah, Navjot
Singh, Rumani
Manjunath, Kavyashree
Uthayakumar, M.
Kanaujia, Shankar P.
Kaul, Sunil C.
Sekar, Kanagaraj
Wadhwa, Renu
Publication Title: 
Journal of Ethnopharmacology

Ayurveda is considered to be the traditional science of health in India and is based on the principle of subjectivity. All matter is composed of five basic elements, which can be perceived by the five sense organs. All food and drugs are classified according to their pharmacological properties, which are derived from these five elements. To investigate which Ayurvedic plants might have cytostatic activity, an Ayurvedic model for the pathogenesis of cancer was made. Based on this, selection criteria were formed, that were used to select plants from a list of Ayurvedic herbal drugs.

Author(s): 
Smit, H. F.
Woerdenbag, H. J.
Singh, R. H.
Meulenbeld, G. J.
Labadie, R. P.
Zwaving, J. H.
Publication Title: 
Journal of Ethnopharmacology

Ayurveda is considered to be the traditional science of health in India and is based on the principle of subjectivity. All matter is composed of five basic elements, which can be perceived by the five sense organs. All food and drugs are classified according to their pharmacological properties, which are derived from these five elements. To investigate which Ayurvedic plants might have cytostatic activity, an Ayurvedic model for the pathogenesis of cancer was made. Based on this, selection criteria were formed, that were used to select plants from a list of Ayurvedic herbal drugs.

Author(s): 
Smit, H. F.
Woerdenbag, H. J.
Singh, R. H.
Meulenbeld, G. J.
Labadie, R. P.
Zwaving, J. H.
Publication Title: 
Neurotoxicology

Despite the increasing popularity of Centella asiatica (a well known plant in ayurvedic medicine) globally, evidence demonstrating its protective efficacy against neurotoxicants in animal models is limited. 3-Nitropropionic acid (3-NPA), a fungal toxin is a well known neurotoxicant which induces selective striatal pathology similar to that seen in Huntington's disease. The present study aimed to understand the neuroprotective efficacy of a standardized aqueous extract of C.

Author(s): 
Shinomol, George K.
Muralidhara, null
Publication Title: 
PloS One

BACKGROUND AND PURPOSE: Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a steroid-backbone bound to a lactone or its derivatives. They are known to protect plants against herbivores and have medicinal value including anti-inflammation, anti-cancer, adaptogenic and anti-oxidant effects. Withaferin A (Wi-A) and Withanone (Wi-N) are two structurally similar withanolides isolated from Withania somnifera, also known as Ashwagandha in Indian Ayurvedic medicine.

Author(s): 
Vaishnavi, Kirti
Saxena, Nishant
Shah, Navjot
Singh, Rumani
Manjunath, Kavyashree
Uthayakumar, M.
Kanaujia, Shankar P.
Kaul, Sunil C.
Sekar, Kanagaraj
Wadhwa, Renu
Publication Title: 
Liver International: Official Journal of the International Association for the Study of the Liver

BACKGROUND/AIMS: Iron overload can cause liver toxicity and increase the risk of liver failure or hepatocellular carcinoma in humans. Curcumin (diferuloylmethane), a component of the food spice turmeric, has antioxidant, iron binding and hepatoprotective properties. The aim of this study was to quantify its effects on iron overload and the resulting downstream toxic effects in cultured T51B rat liver epithelial cells. METHODS: T51B cells were loaded with ferric ammonium citrate (FAC) with or without the iron delivery agent 8-hydroxyquinoline.

Author(s): 
Messner, Donald J.
Sivam, Gowsala
Kowdley, Kris V.

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