Th1 Cells

Publication Title: 
Phytotherapy research: PTR

Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants or plant derivatives that are effective on inflammatory diseases by inhibiting Th1 and Th17 responses.

Asadi-Samani, Majid
Bagheri, Nader
Rafieian-Kopaei, Mahmoud
Shirzad, Hedayatollah
Publication Title: 
Child and Adolescent Psychiatric Clinics of North America

This article reviews the etiology, clinical characteristics, and treatment of inflammatory bowel disease (IBD) and associated psychological sequelae in children and adolescents with this lifelong disease. Pediatric-onset IBD, consisting of Crohn's disease and ulcerative colitis, has significant medical morbidity and in many young persons is also associated with psychological and psychosocial challenges.

Szigethy, Eva
McLafferty, Laura
Goyal, Alka
Publication Title: 
Journal of Biomedicine & Biotechnology

In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S.

Xu, Xinyu
Wen, Xiaoyun
Chi, Ying
He, Lei
Zhou, Sha
Wang, Xuefeng
Zhao, Jiaqing
Liu, Feng
Su, Chuan
Publication Title: 

Indukantha Ghritha (IG) is a polyherbal preparation consisting of 17 plant components widely prescribed by ayurvedic physicians for various ailments. Though it is a known ayurvedic drug, no attempt has been made to scientifically validate its mechanism of action. Preliminary studies in our laboratory showed IG to possess considerable immunomodulatory effects with a Th1 type of immune response. In this regard, we attempted to elucidate its role as an adjuvant to cancer chemotherapy.

George, Suraj K.
Rajesh, R.
Kumar S, Sunil
Sulekha, B.
Balaram, Prabha
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Roots of Asparagus racemosus Willd (Shatavari in vernacular) are widely used in Ayurveda as Rasayana for immunostimulation, galactogogue as also in treatment of conditions like ulcers and cancer. Various studies have indicated immunomodulatory properties of Shatavari root extracts and formulations. AIM OF THE STUDY: To study the effect of standardized Asparagus racemosus root aqueous extract (ARE) on systemic Th1/Th2 immunity of SRBC sensitized animals.

Gautam, Manish
Saha, Santanu
Bani, Sarang
Kaul, A.
Mishra, Sanjay
Patil, Dada
Satti, N. K.
Suri, K. A.
Gairola, Sunil
Suresh, K.
Jadhav, Suresh
Qazi, G. N.
Patwardhan, Bhushan
Publication Title: 
Parasite Immunology

Withania somnifera is an ayurvedic Indian medicinal plant whose immunomodulatory activities have been widely used as a home remedy for several ailments. We recently observed immunostimulatory properties in the root extracts of chemotypes NMITLI-101, NMITLI-118, NMITLI-128 and pure withanolide, withaferin A. In the present study, we evaluated the potential immunoprophylactic efficacies of these extracts against an infective pathogen.

Kushwaha, S.
Soni, V. K.
Singh, P. K.
Bano, N.
Kumar, A.
Sangwan, R. S.
Misra-Bhattacharya, S.
Publication Title: 
Clinical and Diagnostic Laboratory Immunology

Traditional herbal formulas used to treat inflammatory arthritis in China and India include Boswellia carterii or Boswellia serrata. They both contain boswellic acids (BAs) which have been shown to exhibit anti-inflammatory and antiarthritic properties. This study tests the hypothesis that mixtures of BAs derived from B. carterii have immunomodulatory properties. B.

Chevrier, Marc R.
Ryan, Abigail E.
Lee, David Y.-W.
Zhongze, Ma
Wu-Yan, Zhang
Via, Charles S.
Publication Title: 
Molecular Aspects of Medicine

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)(2)D(3) treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)(2)D(3) treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)(2)D(3) treatment.

Cantorna, Margherita T.
Yu, Sanhong
Bruce, Danny
Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: ImmuBalance is a koji fungus (Aspergillus oryzae) and lactic acid fermented soybean product. This unique production process is believed to create a food supplement that helps to induce or maintain normal immune response. OBJECTIVE: To assess possible therapeutic effects of ImmuBalance on peanut (PN) hypersensitivity using a murine model of peanut allergy (PNA).

Zhang, T.
Pan, W.
Takebe, M.
Schofield, B.
Sampson, H.
Li, X.-M.
Publication Title: 
Journal of Affective Disorders

BACKGROUND: A large body of evidence suggests that immune system dysregulation is associated with Major Depressive Disorder (MDD) in adults. This study extends this work to adolescent MDD to examine the hypotheses of immune system dysregulation in adolescents with MDD, as manifested by significantly: (i) elevated plasma levels of cytokines (interferon [IFN]-gamma, tumor necrosis factor-alpha, interleukin [IL]-6, IL-1beta, and IL-4); and (ii) Th1/Th2 cytokine imbalance shifted toward Th1 as indexed by increased IFN-gamma/IL-4.

Gabbay, Vilma
Klein, Rachel G.
Alonso, Carmen M.
Babb, James S.
Nishawala, Melissa
De Jesus, Georgette
Hirsch, Glenn S.
Hottinger-Blanc, Pauline M. Z.
Gonzalez, Charles J.


Subscribe to RSS - Th1 Cells