Th1-Th2 Balance

Publication Title: 
Critical Reviews in Immunology

The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes cell proliferation and tissue repair. Remarkably, the molecules primarily responsible for these "Fight" (NO) or "Fix" (Ornithine) activities both arise from arginine, and via enzymatic pathways (iNOS and arginase) that down regulate each other.

Author(s): 
Mills, Charles D.
Publication Title: 
Phytotherapy research: PTR

Indukantha Ghritha (IG), a polyherbal drug used for centuries in Ayurveda, is claimed to be successful in the treatment of respiratory diseases and as a rejuvenating drug. To date, little is known about the immunomodulatory role of IG in recurrent upper respiratory tract infections (RURIs). This study was designed to scientifically validate and evaluate the immunological response mechanisms in patients with RURI.

Author(s): 
Radhakrishnan, Rajesh
George, Suraj K.
Kumar, Sunil
Balaram, Prabha
Publication Title: 
BioFactors (Oxford, England)

For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells.

Author(s): 
Pino-Lagos, Karina
Guo, Yanxia
Noelle, Randolph J.
Publication Title: 
European Journal of Immunology

MicroRNAs (miRNAs) play important roles in the regulation of immune responses. There is evidence that miRNAs also participate in the pathogenesis of multiple sclerosis (MS), but how the miRNAs regulate the pathogenesis of MS is still under investigation. The identification of new members of the miRNA family associated with the pathogenesis of MS could facilitate early diagnosis and treatment. Here, we show that the level of miRNA let-7e is significantly upregulated in EAE, an animal model of MS using miRNA array and quantitative real-time PCR.

Author(s): 
Guan, Hongbing
Fan, Daping
Mrelashvili, Davit
Hao, Haiping
Singh, Narendra P.
Singh, Udai P.
Nagarkatti, Prakash S.
Nagarkatti, Mitzi
Publication Title: 
Journal of Leukocyte Biology

DHA is a n-3 LCPUFA in fish oil that generally suppresses T lymphocyte function. However, the effect of fish oil on B cell function remains relatively understudied. Given the important role of B cells in gut immunity and increasing human fish oil supplementation, we sought to determine whether DFO leads to enhanced B cell activation in the SMAD-/- colitis-prone mouse model, similar to that observed with C57BL/6 mice. This study tested the hypothesis that DHA from fish oil is incorporated into the B cell membrane to alter lipid microdomain clustering and enhance B cell function.

Author(s): 
Gurzell, Eric A.
Teague, Heather
Harris, Mitchel
Clinthorne, Jonathan
Shaikh, Saame Raza
Fenton, Jenifer I.
Publication Title: 
PloS One

Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize the effects of EA on the EAE. Female Lewis rats were divided into either CFA, EAE, EA, or injection with naloxone after electroacupuncture (NAL) groups. Electroacupuncture was administered every day for 21 days.

Author(s): 
Liu, Yumei
Wang, Hongwei
Wang, Xinyue
Mu, Lili
Kong, Qingfei
Wang, Dandan
Wang, Jinghua
Zhang, Yao
Yang, Jinfeng
Zhou, Mingyan
Wang, Guangyou
Sun, Bo
Li, Hulun
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