Therapeutics

Publication Title: 
Annales Francaises D'anesthesie Et De Reanimation

Analgesia and hypnosis are two separate entities and should result in distinct assessment and management for patients admitted to an intensive care unit (ICU). Those patients are exposed to moderate-severe pain and they are likely to remember pain as one bothersome experience. Any cause of patient discomfort is sought with the priority given to pain and adequate analgesia. Assessing pain must rely upon the use of clinical scoring systems, although these instruments are still underused in ICU.

Author(s): 
Payen, J.-F.
Chanques, G.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis

The aim of this systematic review was to estimate the efficiency of hypnosis prior to medical procedures. Different databases were analyzed to identify randomized controlled trials (RCTs) comparing hypnosis to control interventions. All RCTs had to report pain or anxiety. Eighteen RCTs with a total of 968 patients were included; study size was from 20 to 200 patients (14 RCTs ? 60 patients). Fourteen RCTs included 830 adults and 4 RCTs included 138 children.

Author(s): 
Cheseaux, Nicole
de Saint Lager, Alix Juillet
Walder, Bernhard
Publication Title: 
GMS health technology assessment

BACKGROUND: The prevalence, diagnostics and therapy of the burnout syndrome are increasingly discussed in the public. The unclear definition and diagnostics of the burnout syndrome are scientifically criticized. There are several therapies with unclear evidence for the treatment of burnout in existence. OBJECTIVES: The health technology assessment (HTA) report deals with the question of usage and efficacy of different burnout therapies. METHODS: For the years 2006 to 2011, a systematic literature research was done in 31 electronic databases (e.g. EMBASE, MEDLINE, PsycINFO).

Author(s): 
Korczak, Dieter
Wastian, Monika
Schneider, Michael
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Recent reviews have indicated that low level level laser therapy (LLLT) is ineffective in lateral elbow tendinopathy (LET) without assessing validity of treatment procedures and doses or the influence of prior steroid injections. METHODS: Systematic review with meta-analysis, with primary outcome measures of pain relief and/or global improvement and subgroup analyses of methodological quality, wavelengths and treatment procedures. RESULTS: 18 randomised placebo-controlled trials (RCTs) were identified with 13 RCTs (730 patients) meeting the criteria for meta-analysis.

Author(s): 
Bjordal, Jan M.
Lopes-Martins, Rodrigo Ab
Joensen, Jon
Couppe, Christian
Ljunggren, Anne E.
Stergioulas, Apostolos
Johnson, Mark I.
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Recent reviews have indicated that low level level laser therapy (LLLT) is ineffective in lateral elbow tendinopathy (LET) without assessing validity of treatment procedures and doses or the influence of prior steroid injections. METHODS: Systematic review with meta-analysis, with primary outcome measures of pain relief and/or global improvement and subgroup analyses of methodological quality, wavelengths and treatment procedures. RESULTS: 18 randomised placebo-controlled trials (RCTs) were identified with 13 RCTs (730 patients) meeting the criteria for meta-analysis.

Author(s): 
Bjordal, Jan M.
Lopes-Martins, Rodrigo Ab
Joensen, Jon
Couppe, Christian
Ljunggren, Anne E.
Stergioulas, Apostolos
Johnson, Mark I.
Publication Title: 
GMS health technology assessment

BACKGROUND: Menopause is described as the transition from the reproductive phase of a women to the non reproductive. Changes in hormone levels might lead to complaints and health consequences especially during peri- and postmenopause. Hormone therapy has a potential damaging health risk profile and is recommended for temporal limited therapy for acute vasomotor symptoms only.

Author(s): 
Aidelsburger, Pamela
Schauer, Svenja
Grabein, Kristin
Wasem, Jürgen
Publication Title: 
Stroke

BACKGROUND AND PURPOSE: Central poststroke pain is a chronic neuropathic disorder that follows a stroke. Current research on its management is limited, and no review has evaluated all therapies for central poststroke pain. METHODS: We conducted a systematic review of randomized controlled trials to evaluate therapies for central poststroke pain. We identified eligible trials, in any language, by systematic searches of AMED, CENTRAL, CINAHL, DARE, EMBASE, HealthSTAR, MEDLINE, and PsychINFO.

Author(s): 
Mulla, Sohail M.
Wang, Li
Khokhar, Rabia
Izhar, Zain
Agarwal, Arnav
Couban, Rachel
Buckley, D. Norman
Moulin, Dwight E.
Panju, Akbar
Makosso-Kallyth, Sun
Turan, Alparslan
Montori, Victor M.
Sessler, Daniel I.
Thabane, Lehana
Guyatt, Gordon H.
Busse, Jason W.
Publication Title: 
Iranian Journal of Medical Sciences

BACKGROUND: Pruritus is an unpleasant feeling that can cause the desire of scratching in a person and can be the symptoms of systemic, infectious, and neurological diseases. Pruritus is the most common clinical manifestation of skin diseases. Pruritus prevalence is 8-38% in the general population. Causes and treatments of pruritus have been described by traditional Persian medicine scientists. The aim of this study was to derive general principles of the proposed treatment to reduce or relieve pruritus.

Author(s): 
Jazani, Arezoo Moini
Azgomi, Ramin Nasimi Doost
Shirbeigi, Leila
Publication Title: 
Archives of Dermatological Research

Sirtuins are a family of seven proteins in humans (SIRT1-SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as "longevity proteins" that may extend and enhance human life.

Author(s): 
Serravallo, Melissa
Jagdeo, Jared
Glick, Sharon A.
Siegel, Daniel M.
Brody, Neil I.
Publication Title: 
Pharmacology & Therapeutics

Despite intensive research over many years, the treatment of schizophrenia remains a major health issue. Current and emerging treatments for schizophrenia are based upon the classical dopamine and glutamate hypotheses of disease. Existing first and second generation antipsychotic drugs based upon the dopamine hypothesis are limited by their inability to treat all symptom domains and their undesirable side effect profiles. Third generation drugs based upon the glutamate hypothesis of disease are currently under evaluation but are more likely to be used as add on treatments.

Author(s): 
Winchester, Catherine L.
Pratt, Judith A.
Morris, Brian J.

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