Threonine

Publication Title: 
Cell Cycle (Georgetown, Tex.)

In many organisms, attenuation of growth signaling by caloric restriction or mutational inactivation of growth signaling pathways extends lifespan and protects against cancer and other age-related diseases. The focus of many efforts to understand these effects has been on the induction of oxidative stress defenses that inhibit cellular senescence and cell death. Here we show that in the model organism S.

Author(s): 
Weinberger, Martin
Sampaio-Marques, Belém
Ludovico, Paula
Burhans, William C.
Publication Title: 
Nature

Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at high levels similar to that of histones, and binds to methylated cytosines broadly across the genome. By phosphotryptic mapping, we identify three sites (S86, S274 and T308) of activity-dependent MeCP2 phosphorylation.

Author(s): 
Ebert, Daniel H.
Gabel, Harrison W.
Robinson, Nathaniel D.
Kastan, Nathaniel R.
Hu, Linda S.
Cohen, Sonia
Navarro, Adrija J.
Lyst, Matthew J.
Ekiert, Robert
Bird, Adrian P.
Greenberg, Michael E.
Publication Title: 
The Journal of Nutrition

Whether fetal growth retardation could be induced by diets apparently adequate in protein and energy sources, but imbalanced relative to a single amino acid, was investigated.

Author(s): 
Metcoff, J.
Cole, T. J.
Luff, R.
Publication Title: 
Biochemical and Biophysical Research Communications

We examined in HepG2 cells whether glucose-induced changes in AMP-activated protein kinase (AMPK) activity could be mediated by SIRT1, an NAD(+)-dependent histone/protein deacetylase that has been linked to the increase in longevity caused by caloric restriction. Incubation with 25 vs. 5mM glucose for 6h concurrently diminished the phosphorylation of AMPK (Thr 172) and ACC (Ser 79), increased lactate release, and decreased the abundance and activity of SIRT1. In contrast, incubation with pyruvate (0.1 and 1mM) for 2h increased AMPK phosphorylation and SIRT1 abundance and activity.

Author(s): 
Suchankova, Gabriela
Nelson, Lauren E.
Gerhart-Hines, Zachary
Kelly, Meghan
Gauthier, Marie-Soleil
Saha, Asish K.
Ido, Yasuo
Puigserver, Pere
Ruderman, Neil B.
Publication Title: 
Cell Cycle (Georgetown, Tex.)

In many organisms, attenuation of growth signaling by caloric restriction or mutational inactivation of growth signaling pathways extends lifespan and protects against cancer and other age-related diseases. The focus of many efforts to understand these effects has been on the induction of oxidative stress defenses that inhibit cellular senescence and cell death. Here we show that in the model organism S.

Author(s): 
Weinberger, Martin
Sampaio-Marques, Belém
Ludovico, Paula
Burhans, William C.
Publication Title: 
BMC veterinary research

BACKGROUND: The purpose of this study was to test the hypothesis that dog plasma concentrations of selected nutrients decrease after undergoing caloric restriction for weight loss. Thirty-one overweight dogs that had successfully lost at least 15% of initial body weight were included in the study. Nutrients that had been previously identified to be at potential risk of deficiency during caloric restriction were measured in plasma (choline, amino acids) and urine (selenium) at the initiation and completion of a standardized weight loss regimen in dogs.

Author(s): 
Linder, Deborah E.
Freeman, Lisa M.
Holden, Shelley L.
Biourge, Vincent
German, Alexander J.
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