Thrombolytic Therapy

Publication Title: 
The American Journal of Cardiology

With the introduction of novel oral anticoagulants (NOACs), the factors driving anticoagulant selection in atrial fibrillation (AF) in real-world practice are unclear. The goal was to examine whether and to what extent utilization has been driven by predictions of stroke risk (treatment benefit), bleeding risk (treatment harm), or prescription benefits' coverage. We extracted a cohort of patients with nonvalvular AF initiating anticoagulation from October 2010 to December 2012 from a large US database of commercial and Medicare supplement claims.

Lauffenburger, Julie C.
Farley, Joel F.
Gehi, Anil K.
Rhoney, Denise H.
Brookhart, M. Alan
Fang, Gang
Publication Title: 
Journal of Medical Ethics

BACKGROUND: Informed consent is regarded as a contract between autonomous and equal parties and requires the elements of information disclosure, understanding, voluntariness and consent. The validity of informed consent for critically ill patients has been questioned. Little is known about how these patients experience the process of consent. OBJECTIVE: The aim of this study was to explore critically ill patients' experience with the principle of informed consent in a clinical trial and their ability to give valid informed consent.

Mangset, M.
F¯rde, R.
Nessa, J.
Berge, E.
Wyller, T. Bruun
Publication Title: 
Archives Des Maladies Du Coeur Et Des Vaisseaux

Cardiogenic shock is a very serious complication of acute myocardial infarction because of its prevalence (10-15% of cases) and the associated mortality of 80 to 90 per cent despite the availability of new inotropic drugs and intra-aortic balloon counterpulsation. The aim of this study was to show that revascularisation by percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction complicated by cardiogenic shock completely changes the prognosis.

Meyer, P.
Blanc, P.
Baudouy, M.
Morand, P.
Publication Title: 
Journal of Interventional Cardiology

In two patients with massive pulmonary embolism and cardiogenic shock requiring mechanical ventilation and prolonged external cardiac massage, occluded pulmonary arteries were recanalized by primary mechanical fragmentation of thrombi using a percutaneously inserted catheter followed by fibrinolytic therapy. The hemodynamic and respiratory parameters rapidly and greatly improved. Pulmonary angiography before discharge revealed normal results in both patients. No central neurological abnormalities were detected.

Sigmund, M.
Rubart, M.
Vom Dahl, J.
Uebis, R.
Hanrath, P.
Publication Title: 
Der Radiologe

Central retinal artery occlusion is known to have a poor natural outcome, and also conventional therapeutic procedures e.g. paracentesis, hemodilution or local massage show unfavorable results. As in intraarterial fibrinolytic therapy in cerebral vessels, we also applied this method to the territory of the ophthalmic artery in 6 patients with occlusion of the central retinal artery. The fibrinolysis was done with a microcatheter superselectively, placed in the proximal part of the ophthalmic artery. The amount of urokinase varied from 200,000 to 900,000 IU, diluted in saline solution.

Schumacher, M.
Schmidt, D.
Wakhloo, A. K.
Publication Title: 
The American Journal of Cardiology

Prolonged external cardiac massage is often regarded as a contraindication for thrombolytic therapy because of the risk of fatal hemorrhage. The influence of cardiopulmonary resuscitation on complications of thrombolytic bleeding was assessed analyzing data of all patients with myocardial infarction admitted to our clinic during the 10-year period between 1978 and 1987. From the total of 2,147 patients with acute myocardial infarction, 590 received thrombolytic therapy (intracoronary in 229, intravenous in 400).

Scholz, K. H.
Tebbe, U.
Herrmann, C.
Wojcik, J.
Lingen, R.
Chemnitius, J. M.
Brune, S.
Kreuzer, H.
Publication Title: 
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS

Circulatory effects of cardiopulmonary resuscitation with active compression-decompression (CPR-ACD) are superior to the conventional technique. Decompression, thoracic expansion and a corresponding suction effect obviously improves cardiac preload. Due to significant or unphysiological thoracic expansion, thorax, diaphragma, and epigastrium are exposed to considerable traction powers. In a patient with fulminant pulmonary embolism, conventional cardiac massage and ACD were maintained during 65 minutes with simultaneous systemic thrombolytic therapy.

Adams, H. A.
Hempelmann, G.
Beigl, B.
Schmitz, C. S.
Publication Title: 
Intensive Care Medicine

OBJECTIVE: Successful resuscitation of the brain requires complete microcirculatory reperfusion, which, however, may be impaired by activation of blood coagulation after cardiac arrest. The study addresses the question of whether postischemic thrombolysis is effective in reducing cerebral no-reflow phenomenon. DESIGN: 14 adult normothermic cats were submitted to 15-min cardiac arrest, followed by cardiopulmonary resuscitation (CPR) and 30 min of spontaneous recirculation.

Fischer, M.
Böttiger, B. W.
Popov-Cenic, S.
Hossmann, K. A.
Publication Title: 

The authors present three case reports retrospectively casting doubt on the benefit of thrombolysis after external cardiac massage.

Cafri, C.
Gilutz, H.
Ilia, R.
Abu-ful, A.
Battler, A.
Publication Title: 
Swiss Surgery = Schweizer Chirurgie = Chirurgie Suisse = Chirurgia Svizzera

After external cardiac massage, 3-8% of patients present potentially dangerous liver lacerations. Here we discuss the case of a patient who presented a major haemodynamic instability following external cardiac massage and thrombolytic therapy. Falsely attributed to a cardiac complication, this was actually consecutive to a hepatic haemorrhage originating from liver lacerations caused by the cardiac massage. Haemodynamic stability was obtained by reestablishing blood volume and coagulation factors. Following this the patient evolved favorably.

Froment, P.
Savioz, D.
Robertson, M.
Morel, P.


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