Thyroid Gland

Publication Title: 
Molecular and Cellular Endocrinology

This review focuses on research involving calorie restriction (CR) in humans and the resulting changes observed in endocrine and neuroendocrine systems. Special emphasis is given to the clinical science studies designed to investigate the effects of controlled, high-quality, energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases of human aging. Prolonged CR has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats and mice.

Author(s): 
Redman, Leanne M.
Ravussin, Eric
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: A relation between low thyroid activity and prolonged life span in humans has been observed. Several studies have demonstrated hereditary and genetic influences on thyroid function. OBJECTIVE: The objective of the study was to test whether low thyroid activity associated with extreme longevity constitutes a heritable phenotype, which could contribute to the familial longevity observed in the Leiden Longevity Study. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at a university hospital in the city of Leiden, The Netherlands.

Author(s): 
Rozing, M. P.
Houwing-Duistermaat, J. J.
Slagboom, P. E.
Beekman, M.
Frˆlich, M.
de Craen, A. J. M.
Westendorp, R. G. J.
van Heemst, D.
Publication Title: 
Endocrine Reviews

Studies in humans and in animal models show negative correlations between thyroid hormone (TH) levels and longevity. TH signaling is implicated in maintaining and integrating metabolic homeostasis at multiple levels, notably centrally in the hypothalamus but also in peripheral tissues. The question is thus raised of how TH signaling is modulated during aging in different tissues. Classically, TH actions on mitochondria and heat production are obvious candidates to link negative effects of TH to aging.

Author(s): 
Bowers, J.
Terrien, J.
Clerget-Froidevaux, M. S.
GothiÈ, J. D.
Rozing, M. P.
Westendorp, R. G. J.
van Heemst, D.
Demeneix, B. A.
Publication Title: 
Molecular and Cellular Endocrinology

This review focuses on research involving calorie restriction (CR) in humans and the resulting changes observed in endocrine and neuroendocrine systems. Special emphasis is given to the clinical science studies designed to investigate the effects of controlled, high-quality, energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases of human aging. Prolonged CR has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats and mice.

Author(s): 
Redman, Leanne M.
Ravussin, Eric
Publication Title: 
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Author(s): 
Sharpe, A. R.
Gardner, C. T.
Cassida, W. A.
Blackburn, E.
Publication Title: 
Experimental and Clinical Endocrinology

It is truly a great honor to be the 1994 recipient of the Berthold Memorial Award from the German Endocrine Society which met in W¸rzburg, March 2-5. I am especially indebted to Drs. Kˆhrle and Wuttke for their kindness in making our visit to W¸rzburg so enjoyable and educational. Professor Berthold was the first to demonstrate the effects of a hormone on phenotypic expression when he transplanted testes to a castrated rooster, restoring its masculine appearance and behavior (Figure 1) (Berthold, 1849). Since 1960, when I joined the laboratory of the late Dr. Sidney H.

Author(s): 
Braverman, L. E.
Publication Title: 
Experimental and Clinical Endocrinology

It is truly a great honor to be the 1994 recipient of the Berthold Memorial Award from the German Endocrine Society which met in W¸rzburg, March 2-5. I am especially indebted to Drs. Kˆhrle and Wuttke for their kindness in making our visit to W¸rzburg so enjoyable and educational. Professor Berthold was the first to demonstrate the effects of a hormone on phenotypic expression when he transplanted testes to a castrated rooster, restoring its masculine appearance and behavior (Figure 1) (Berthold, 1849). Since 1960, when I joined the laboratory of the late Dr. Sidney H.

Author(s): 
Braverman, L. E.
Publication Title: 
Folia Endocrinologica; Mensile Di Incretologia E Incretoterapia
Author(s): 
Lacroix, L.
Cravetto, C.
Marini, M. P.
Publication Title: 
Annales De Chirurgie

Retrospective studies have confirmed the feasibility and safety of thyroid and parathyroid procedures performed under hypnoanesthesia (hypnosis, local anesthesia and minimal conscious sedation) as sole method of anesthesia. This very effective technique seems to provide physiological, psychological and economic benefits for the patient. STUDY AIM: To assess, by means of a prospective randomized study, the advantages of hypnosedation as an alternative to general anesthesia in terms of clinical and laboratory parameters.

Author(s): 
Defechereux, T.
Degauque, C.
Fumal, I.
Faymonville, M. E.
Joris, J.
Hamoir, E.
Meurisse, M.
Publication Title: 
Anesthesia and Analgesia

Hypnotics and opioids interact synergistically to block responses to surgery and different dose combinations may be used to provide adequate anesthesia. In this study, we sought to determine the optimal concentrations of propofol and sufentanil, given by target-controlled infusions, to ensure hemodynamic stability, adequate hypnosis (assessed by electroencephalogram bispectral index), and fast recovery for a moderately painful operation.

Author(s): 
Hentgen, Elisabeth
Houfani, Malik
Billard, Valérie
Capron, Florent
Ropars, Jean-Marc
Travagli, Jean Paul

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