Thyroid Hormones

Publication Title: 
Endocrine Reviews

Studies in humans and in animal models show negative correlations between thyroid hormone (TH) levels and longevity. TH signaling is implicated in maintaining and integrating metabolic homeostasis at multiple levels, notably centrally in the hypothalamus but also in peripheral tissues. The question is thus raised of how TH signaling is modulated during aging in different tissues. Classically, TH actions on mitochondria and heat production are obvious candidates to link negative effects of TH to aging.

Bowers, J.
Terrien, J.
Clerget-Froidevaux, M. S.
GothiÈ, J. D.
Rozing, M. P.
Westendorp, R. G. J.
van Heemst, D.
Demeneix, B. A.
Publication Title: 
Experimental Gerontology
Everitt, A. V.
Publication Title: 
Experimental Gerontology

A significant increase in the number of old people in the populations of developed countries was followed by an increase in morbidity and mortality resulting from main age-related diseases -- cardiovascular, cancer, neurodegenerative, diabetes mellitus, decrease in resistance to infections. Obviously, the development of the means of prevention of the premature aging of humans is crucial for the realization of this program.

Anisimov, V. N.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: This study was designed to answer the question: Does the contact of the human organism with the Earth via a copper conductor affect physiologic processes?

Sokal, Karol
Sokal, Pawel
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Sonchus asper (L.) Hill, (Asteraceae) is used in Pakistan as a traditional ("folk") medicine for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Sonchus asper (L.) Hill, (Asteraceae) methanolic extract (SAME) on hormonal dysfunction in thyroid tissue after carbon tetrachloride (CCl4)-induced oxidative stress. METHODS: To examine the effects of SAME against the oxidative stress of CCl4 in thyroid tissue, 30 male albino rats were used.

Khan, Rahmat Ali
Publication Title: 
The American Journal of Clinical Nutrition

Male Sprague-Dawley rats were fed a zinc-deficient diet to study its effects on the hypothalamic-pituitary-thyroid axis. As zinc-deficient animals fail to gain weight, they were compared to pair-fed growth restricted animals as well as ad libitum fed controls. The growth velocity curves were superimposable for the zinc-deficient animals and the pair-fed controls; both were markedly reduced compared to the ad libitum controls. Both the zinc-deficient and the pair-fed controls had lower triiodothyronine (T3) and thyroxine levels compared to the ad libitum controls.

Morley, J. E.
Gordon, J.
Hershman, J. M.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Peripheral metabolism of thyroid hormones is a critical component of the impact these hormones have on intracellular function. Thyroid hormones can be metabolized in peripheral tissue by deiodination, conjugation, deamination, and decarboxylation enzyme reactions. Therefore, alterations in these metabolic pathways might significantly impact the quantity of specific thyroid hormone metabolites influencing function at the cellular level.

Kelly, G. S.
Publication Title: 
The Journal of Biological Chemistry

The orphan nuclear receptor CAR (NR1I3) has been characterized as a central component in the coordinate response to xenobiotic and endobiotic stress. In this study, we demonstrate that CAR plays a pivotal function in energy homeostasis and establish an unanticipated metabolic role for this nuclear receptor. Wild-type mice treated with the synthetic CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) exhibited decreased serum concentration of the thyroid hormone (TH) thyroxine (T(4)). However, treatment of Car(-/-) mice with TCPOBOP failed to elicit these changes.

Maglich, Jodi M.
Watson, Joe
McMillen, Patrick J.
Goodwin, Bryan
Willson, Timothy M.
Moore, John T.
Publication Title: 

STUDY OBJECTIVE: To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy. DESIGN: Case controlled pilot study. SETTINGS: University hospital. PARTICIPANTS: 13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.

Chabas, Dorothée
Foulon, Christine
Gonzalez, Jesus
Nasr, Mireille
Lyon-Caen, Olivier
Willer, Jean-Claude
Derenne, Jean-Philippe
Arnulf, Isabelle
Publication Title: 
The Journal of Endocrinology

During food restriction, decreased basal metabolic rate secondary to reduced serum thyroid hormones levels contributes to weight loss resistance. Thyroxine (T(4)) and 3,3',5-tri-iodothyronine (T(3)) administration during caloric restriction produce deleterious side effects; however, the administration of physiological doses of T(4) during food restriction has never been evaluated. The aim of this study was to analyze the effects of low replacement doses of T(4) in Wistar rats subjected to 40% food restriction.

Araujo, Renata Lopes
de Andrade, Bruno Moulin
de Figueiredo, Alvaro Souto Padron
da Silva, Monique Leandro
Marassi, Michelle Porto
Pereira, Valmara dos Santos
Bouskela, Eliete
Carvalho, Denise P.


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