Thyrotropin

Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: The distribution of serum TSH shifts progressively to higher concentrations with age. OBJECTIVE: The aim of the study was to determine whether the population shift in TSH distribution to higher concentrations with aging extends to people of exceptional longevity, namely centenarians, and to assess the relationship between concentrations of TSH and free T(4) (FT4).

Author(s): 
Atzmon, Gil
Barzilai, Nir
Hollowell, Joseph G.
Surks, Martin I.
Gabriely, Ilan
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Exceptional longevity is associated with raised serum TSH. OBJECTIVE: The aim of this study was to examine whether offspring of people with exceptional longevity have elevated serum TSH and whether specific single nucleotide polymorphisms (SNPs) in the TSH-B gene and TSH receptor (TSHR) gene are associated with this phenotype. DESIGN/SETTING/PATIENTS: We measured serum TSH and free T(4) in Ashkenazi Jewish centenarians (n = 232; median age, 97 yr), their offspring (n = 366; median age, 69 yr), and age-matched controls without familial longevity (n = 163; median age, 70 yr).

Author(s): 
Atzmon, Gil
Barzilai, Nir
Surks, Martin I.
Gabriely, Ilan
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: A relation between low thyroid activity and prolonged life span in humans has been observed. Several studies have demonstrated hereditary and genetic influences on thyroid function. OBJECTIVE: The objective of the study was to test whether low thyroid activity associated with extreme longevity constitutes a heritable phenotype, which could contribute to the familial longevity observed in the Leiden Longevity Study. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at a university hospital in the city of Leiden, The Netherlands.

Author(s): 
Rozing, M. P.
Houwing-Duistermaat, J. J.
Slagboom, P. E.
Beekman, M.
Frˆlich, M.
de Craen, A. J. M.
Westendorp, R. G. J.
van Heemst, D.
Publication Title: 
Current Topics in Developmental Biology

Ames dwarf mice and Snell dwarf mice lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH), live much longer than their normal siblings, and exhibit many symptoms of delayed aging. "Laron dwarf mice," produced by targeted disruption of the GH receptor/GH-binding protein gene (GHR-KO mice), are GH resistant and also live much longer than normal animals from the same line. Isolated GH deficiency in "little" mice is similarly associated with increased life span, provided that obesity is prevented by reducing fat content in the diet.

Author(s): 
Bartke, Andrzej
Brown-Borg, Holly
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: This study was designed to answer the question: Does the contact of the human organism with the Earth via a copper conductor affect physiologic processes?

Author(s): 
Sokal, Karol
Sokal, Pawel
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Abnormal thyroid function test results are common among human immunodeficiency virus (HIV)-infected patients. Although the prevalence of overt thyroid disease does not appear to be significantly increased in HIV-infected patients, compared with the general population, specific patterns of abnormal thyroid function test findings are more frequently identified among HIV-infected patients. Among patients with advanced acquired immunodeficiency syndrome, nonthyroidal illness (i.e., euthyroid sick syndrome) is common.

Author(s): 
Hoffmann, Christopher J.
Brown, Todd T.
Publication Title: 
Thyroidology / A.P.R.I.M

A 57-year-old woman with Hashimoto's disease is described who developed transient destructive thyrotoxicosis subsequently after she underwent physical massage therapy over her shoulder to neck, together with the goiter, for muscle stiffness in that part. This case supports the concept that physical vigorous manipulation might be a contributing factor for thyrotoxicosis in cases predisposed with autoimmune thyroiditis.

Author(s): 
Tachi, J.
Amino, N.
Miyai, K.
Publication Title: 
Voprosy Kurortologii, Fizioterapii, I Lechebnoĭ Fizicheskoĭ Kultury

This study included 27 female patients who applied for medical treatment of arthralgias and myalgias. They were found to have elevated levels of thyroid-stimulating hormone in conjunction with the normal concentrations of thyroid hormones. The therapeutic procedures included corporal and auricular acupuncture, introduction of needles into the reflexogenic scalp and wrist zones (depending on clinical symptoms) and into the thyroid gland projection zones on the skin, massage of paravertebral regions of the cervical and thoracic spine using a bone scraper (the Gua Sha healing technique).

Author(s): 
Luzina, K. É
Luzina, L. L.
Vasilenko, A. M.
Publication Title: 
Endocrinologia Japonica

Alterations in catecholamine (CA) and thyroid hormone metabolism were examined in a 12-year-old girl with anorexia nervosa during 3 months of treatment. According to her body weight change, the observation period was divided into 3 stages: initial emaciation (stage 1), stable maintenance of the -30% level of the previous weight (stage 2) and convalescent stage (stage 3).

Author(s): 
Sato, T.
Igarashi, N.
Miyagawa, K.
Nakajima, T.
Katayama, K.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

The relationship between thyroid function and leptin has been extensively studied; however, the mechanisms underlying the changes in thyroid hormone economy that occur during caloric deprivation remain elusive. Our goal was to evaluate the thyroid function of rats submitted to 40% food restriction after chronic leptin replacement.

Author(s): 
Araujo, R. L.
Andrade, B. M.
da Silva, M. L.
Ferreira, A. C. F.
Carvalho, D. P.

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