Thyroxine

Publication Title: 
International Journal of Molecular Medicine

The sirtuin 1 protein (SIRT1) is a member of the class III NAD+-dependent histone deacetylases, which are also referred to as the 'sirtuins'. The sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis. SIRT1 regulates different cellular processes such as proliferation, differentiation and apoptosis through deacetylation of important regulatory proteins such as p53, FOXO3a and NFkappaB.

Author(s): 
Engel, Nicole
Mahlknecht, Ulrich
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: The distribution of serum TSH shifts progressively to higher concentrations with age. OBJECTIVE: The aim of the study was to determine whether the population shift in TSH distribution to higher concentrations with aging extends to people of exceptional longevity, namely centenarians, and to assess the relationship between concentrations of TSH and free T(4) (FT4).

Author(s): 
Atzmon, Gil
Barzilai, Nir
Hollowell, Joseph G.
Surks, Martin I.
Gabriely, Ilan
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: A relation between low thyroid activity and prolonged life span in humans has been observed. Several studies have demonstrated hereditary and genetic influences on thyroid function. OBJECTIVE: The objective of the study was to test whether low thyroid activity associated with extreme longevity constitutes a heritable phenotype, which could contribute to the familial longevity observed in the Leiden Longevity Study. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at a university hospital in the city of Leiden, The Netherlands.

Author(s): 
Rozing, M. P.
Houwing-Duistermaat, J. J.
Slagboom, P. E.
Beekman, M.
Frˆlich, M.
de Craen, A. J. M.
Westendorp, R. G. J.
van Heemst, D.
Publication Title: 
Experimental and Clinical Endocrinology

It is truly a great honor to be the 1994 recipient of the Berthold Memorial Award from the German Endocrine Society which met in W¸rzburg, March 2-5. I am especially indebted to Drs. Kˆhrle and Wuttke for their kindness in making our visit to W¸rzburg so enjoyable and educational. Professor Berthold was the first to demonstrate the effects of a hormone on phenotypic expression when he transplanted testes to a castrated rooster, restoring its masculine appearance and behavior (Figure 1) (Berthold, 1849). Since 1960, when I joined the laboratory of the late Dr. Sidney H.

Author(s): 
Braverman, L. E.
Publication Title: 
Experimental and Clinical Endocrinology

It is truly a great honor to be the 1994 recipient of the Berthold Memorial Award from the German Endocrine Society which met in W¸rzburg, March 2-5. I am especially indebted to Drs. Kˆhrle and Wuttke for their kindness in making our visit to W¸rzburg so enjoyable and educational. Professor Berthold was the first to demonstrate the effects of a hormone on phenotypic expression when he transplanted testes to a castrated rooster, restoring its masculine appearance and behavior (Figure 1) (Berthold, 1849). Since 1960, when I joined the laboratory of the late Dr. Sidney H.

Author(s): 
Braverman, L. E.
Publication Title: 
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

Yangyin Anshen Koufuye could obviously decrease the spontaneous activity of rats, effectively shorten the process of falling into sleep of normal rats which were injected pentobarbital sodium and prolong the sleeping time. The effect of sedation and hypnotism were the same as Zhaoren Anshen Koufuye. Yangyin Anshen Koufuye also could markedly reduce the serum tensity of T3, T4 of hyperthyroid rats, which equaled to TCM's deficiency of yin.

Author(s): 
Zhong, J.
Wang, X.
Cui, Y.
Zhu, G.
Meng, Y.
Zhang, L.
Yuang, X.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

A recent methodological approach for human classification, diagnosis, and therapeutics through the combination of current Western constitutional psychology somatotypes and traditional Indian medicine (prakriti) body types and mind (manas) is herein presented. The striking similarities between psychologic somatotypes and Indian medicine body types permits proposal of a finite genopsycho-somatotyping of humans.

Author(s): 
Rizzo-Sierra, Carlos V.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

A recent methodological approach for human classification, diagnosis, and therapeutics through the combination of current Western constitutional psychology somatotypes and traditional Indian medicine (prakriti) body types and mind (manas) is herein presented. The striking similarities between psychologic somatotypes and Indian medicine body types permits proposal of a finite genopsycho-somatotyping of humans.

Author(s): 
Rizzo-Sierra, Carlos V.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) constitute a physiologic barrier in the intestine for many of the same substrates. Their expression can be influenced by nuclear receptor NR1I2 (pregnane X receptor; PXR), which acts as a receptor for various endobiotics and xenobiotics. However, P-gp and CYP3A4 are not identical in anatomic localization, suggesting unique as well as shared regulatory mechanisms of gene expression.

Author(s): 
Mitin, Tim
von Moltke, Lisa L.
Court, Michael H.
Greenblatt, David J.
Publication Title: 
Thyroidology / A.P.R.I.M

A 57-year-old woman with Hashimoto's disease is described who developed transient destructive thyrotoxicosis subsequently after she underwent physical massage therapy over her shoulder to neck, together with the goiter, for muscle stiffness in that part. This case supports the concept that physical vigorous manipulation might be a contributing factor for thyrotoxicosis in cases predisposed with autoimmune thyroiditis.

Author(s): 
Tachi, J.
Amino, N.
Miyai, K.

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