Publication Title: 
European Cells & Materials

Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions. We aim to establish an animal model, which reliably mimics the clinical situation. Human microvascular endothelial cells (HMEC-1) and primary human osteoblast like cells (POBs) were cultured with different angiogenesis-inhibitors (Fumagillin, SU5416, Artesunate and 3,5,4'-Trimethoxystilbene) released out of poly(D,L-Lactide) (PDLLA) coated k-wires and cell activity was determined.

Fassbender, M.
Strobel, C.
Rauhe, J. S.
Bergmann, C.
Schmidmaier, G.
Wildemann, B.
Publication Title: 
Journal De Chirurgie

Chronic sclerosing osteomyelitis is a rare variety of primary osteomyelitis located principally on the diaphysis of the long bones in adults. Pain is the main symptom, but biological signs are negative or normal, and histological examination is non-specific. X-rays are very stereotyped with enlargement of the cortex of diaphyseal bone. This disease is note worthy by its difficult diagnosis, and is often misdiagnosed as bone tumor, malignant or benign, especially osteoid osteoma.

Féry, A.
Publication Title: 
European Journal of Pain (London, England)

Cancer pain impairs the quality of life of cancer patients, but opioid intervention can cause significant side effects that further decrease quality of life. Although electroacupuncture (EA) has been used to treat cancer pain, its mechanisms are largely unknown. To examine its effects and underlying mechanisms on cancer pain, we injected AT-3.1 prostate cancer cells into the tibia to induce bone cancer in the male Copenhagen rat.

Zhang, Rui-Xin
Li, Aihui
Liu, Bing
Wang, Linbo
Xin, Jiajia
Ren, Ke
Qiao, Jian-Tian
Berman, Brian M.
Lao, Lixing
Publication Title: 

Preterm delivery (<37 weeks post-menstrual age) is associated with suboptimal bone mass. We hypothesized that tactile/kinesthetic stimulation (TKS), a form of infant massage that incorporates kinesthetic movement, would increase bone strength and markers of bone accretion in preterm infants. Preterm, AGA infants (29-32 weeks) were randomly assigned to TKS (N=20) or Control (N=20). Twice daily TKS was provided 6 days per week for 2 weeks. Control infants received the same care without TKS treatment. Treatment was masked to parents, health care providers, and study personnel.

Haley, S.
Beachy, J.
Ivaska, K. K.
Slater, H.
Smith, S.
Moyer-Mileur, L. J.
Publication Title: 
Journal of Biomechanics

A quasi-linear viscoelasticity (QLV) model was used to study passive time-dependent responses of skeletal muscle to repeated massage-like compressive loading (MLL) following damaging eccentric exercise. Six skeletally mature rabbits were surgically instrumented with bilateral peroneal nerve cuffs for stimulation of the hindlimb tibialis anterior (TA) muscles. Following the eccentric exercise, rabbits were randomly assigned to a four-day MLL protocol mimicking deep effleurage (0.5 Hz, 10 N for 15 min or for 30 min).

Haas, Caroline
Best, Thomas M.
Wang, Qian
Butterfield, Timothy A.
Zhao, Yi
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Estrogen deficiency after menopause results in rapid bone loss, predisposing women to osteoporotic fractures. Genistein, a phytoestrogen present in high concentrations in soy, is an ingredient in dietary supplements aggressively marketed for bone health. However, in a recent long-duration clinical trial in postmenopausal women, the efficacy of soy extracts in reducing bone loss was disappointing.

Turner, Russell T.
Iwaniec, Urszula T.
Andrade, Juan E.
Branscum, Adam J.
Neese, Steven L.
Olson, Dawn A.
Wagner, Lindsay
Wang, Victor C.
Schantz, Susan L.
Helferich, William G.
Publication Title: 
Clinical Biomechanics (Bristol, Avon)

BACKGROUND: The acquisition of flatfoot by an adult is thought to primarily be caused by posterior tibial tendon dysfunction, although some other causes, such as congenital flexible flatfoot or an accessory navicular, may also be responsible. The objective of this study was to evaluate the bone rotation of each joint in the medial longitudinal arch (MLA) and compare the response in healthy feet with that in flat feet by analyzing the reconstructive three-dimensional (3D) CT image data during weightbearing.

Kido, Masamitsu
Ikoma, Kazuya
Imai, Kan
Tokunaga, Daisaku
Inoue, Nozomu
Kubo, Toshikazu
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

OBJECTIVES: Preterm infants are born with low bone mineral. Neonatal stress further impedes bone mineralization. Clinical evidence suggests that tactile and kinesthetic stimulation (TKS) improves bone phenotype and decreases stress response. Clinical and translational studies indicate the IGF-1 axis, responsible for postnatal growth and bone mineralization, is a key player. We hypothesized that TKS would attenuate the negative impact of neonatal stress on bone phenotype and the IGF-1 axis in weanling rats.

Haley, S.
Gulliver, K.
Baldassarre, R.
Miller, S.
Lane, R. H.
Moyer-Mileur, L. J.
Publication Title: 
The American Journal of Sports Medicine

BACKGROUND: Current knowledge is lacking concerning the appropriate site of osteochondral allograft harvest to match glenoid shape for the purposes of glenoid resurfacing. This has led to difficulty with adequate restoration of the geometry of the glenoid with currently available techniques. HYPOTHESIS: The medial tibial plateau will provide a suitable osteochondral harvest site because of its concavity and anatomic similarity to the glenoid. STUDY DESIGN: Descriptive laboratory study.

Gupta, Anil K.
Forsythe, Brian
Lee, Andrew S.
Harris, Joshua D.
McCormick, Frank
Abrams, Geoffrey D.
Verma, Nikhil N.
Romeo, Anthony A.
Inoue, Nozomu
Cole, Brian J.
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

The objects of this study were to investigate the effects of massage therapy during early life on postnatal growth, body composition, and skeletal development in juvenile and young adult rats. Massage therapy was performed for 10 minutes daily from D6 to D10 of postnatal life in rat pups (MT, n=24).

Chen, H.
Miller, S.
Shaw, J.
Moyer-Mileur, L.


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