Toxicity Tests, Acute

Publication Title: 
Indian Journal of Experimental Biology

The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of Terminalia bellerica and T. chebula fruits were evaluated for their analgesic activity using the tail immersion model in mice. The ethanolic extracts of both the plants exhibited analgesic response at 200,400 and 800mg/kg. The studies were further carried for 15 days to evaluate the effect of these extracts in chronic pain and maximum analgesic response was observed on 14th day in both the plants. Phytochemical investigation of ethanolic extract of the fruits of Terminalia bellerica and T.

Kaur, Sarabjit
Jaggi, R. K.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an ?-glucosidase inhibitor. OBJECTIVE: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats. MATERIALS AND METHODS: Chebulic acid (CA) was isolated from T.

Silawat, Narendra
Gupta, Vipin Bihari
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is a botanical preparation comprised of equal proportions ofthe three herbalfruits, namely Terminalia chebula Retz., Tenninalia sp. and Terminalia bellirica Roxb. This recipe is used for antipyretic, expectorant, periodic maintenance, and relieving stomach tight. OBJECTIVE: To evaluate the acute and sub-chronic toxicities of Tri-sa-maw recipe extract in rats. MATERIAL AND METHOD: In the present study of acute toxicity, a single oral dose 5,000 mg/kg of Tri-sa-maw recipe extract was administered to rats.

Nanna, Urarat
Jaijoy, Kanjana
Lertprasertsuke, Nirush
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Cardiovascular Toxicology

In 2011, dozens of children and pregnant women in Korea died by exposure to sterilizer for household humidifier, such as Oxy(Æ) and Cefu(Æ). Until now, however, it remains unknown how the sterilizer affect the human health to cause the acute deaths. To find its toxicity for organ, we investigated the putative toxicity of the sterilizer in the cardiovascular system. The sterilizers, polyhexamethylene guanidine phosphate (PHMG, Cefu(Æ)), and oligo-[2-(2-ethoxy)-ethoxyethyl)-guanidinium-chloride (PGH, Oxy(Æ)) were treated to human lipoproteins, macrophages, and dermal fibroblast cells.

Kim, Jae-Yong
Kim, Hak Hyeon
Cho, Kyung-Hyun
Publication Title: 
Environmental Toxicology and Pharmacology

An efflux pump inhibitor, SK-20 (5-(3,4-methylenedioxyphenyle)-4 ethyl-2E,4E-pentadienoic acid piperidide), was assessed for its toxicity at three different pharmacological profiles: acute, sub-acute and general pharmacology with pharmacokinetics. In acute study, the SK-20 was found safe up to a dose of 2000 mg/kg (b.wt.); and at sub-acute, dosages of 50 and 100 mg/kg (b.wt.) were found to be safe.

Rayees, Sheikh
Sharma, Rohit
Singh, Gurdarshan
Najar, Ishtiyaq Ahmad
Singh, Amarinder
Ahamad, Dastagir Basheer
Sharma, Subash Chander
Tikoo, Manoj Kumar
Gupta, Vijay Kumar
Sangwan, Payare Lal
Singh, Surjeet
Koul, Surinder
Johri, Rakesh Kamal
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera (family Moringaceae), commonly called Horseradish or tree of life, is traditionally used for the treatment of epilepsy and neurologic conditions. AIM OF THE STUDY: The objective of this study is to investigate the neurobehavioural and anticonvulsant properties of the ethanol extract from the leaves of Moringa oleifera. MATERIALS AND METHODS: Neurobehavioural properties were evaluated using the open field, hole board, Y-maze, elevated plus maze (EPM) and pentobarbitone-induced hypnosis.

Bakre, Adewale G.
Aderibigbe, Adegbuyi O.
Ademowo, Olusegun G.
Publication Title: 
The Journal of Toxicological Sciences

Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling.

Chanda, Debabrata
Shanker, Karuna
Pal, Anirban
Luqman, Suaib
Bawankule, Dnyaneshwar Umrao
Mani, Dayanandan
Darokar, Mahendra Pandurang
Publication Title: 
Phytotherapy research: PTR

Associations of plants have been widely used, for centuries, in Ayurveda and in Chinese medicine and have been increasingly acknowledged in Western medicine. The objective of this study is to assess the level of toxicity of an association of three plants: Crataegus oxyacantha, Passiflora incarnata, and Valeriana officinalis (CPV extract). This association was administered to rats, mice, and dogs, both acute and chronically for 180 days. The tests used in the acute experiments were: observational pharmacological screening, LD(50), motor coordination and motor activity.

Tabach, Ricardo
Rodrigues, Eliana
Carlini, E. A.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

The effect of 0, 5, 6.25, 10, 12.5, 20, 25, 40, 50 and 80 mg/kg b. wt. of aqueous extract of triphala (an Ayurvedic herbal medicine) administrered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of triphala consecutively for five days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls.

Jagetia, G. C.
Baliga, M. S.
Malagi, K. J.
Sethukumar Kamath, M.
Publication Title: 
Journal of Ethnopharmacology

From ancient times, Swarnabhasma (gold ash) has been used in several clinical manifestations including loss of memory, defective eyesight, infertility, overall body weakness and incidence of early aging. Swarnabhasma has been used by Ayurvedic physicians to treat different diseases like bronchial asthma, rheumatoid arthritis, diabetes mellitus, nervous disorders, etc.

Mitra, A.
Chakraborty, S.
Auddy, B.
Tripathi, P.
Sen, S.
Saha, A. V.
Mukherjee, B.


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