Toxicity Tests, Subchronic

Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is a botanical preparation comprised of equal proportions ofthe three herbalfruits, namely Terminalia chebula Retz., Tenninalia sp. and Terminalia bellirica Roxb. This recipe is used for antipyretic, expectorant, periodic maintenance, and relieving stomach tight. OBJECTIVE: To evaluate the acute and sub-chronic toxicities of Tri-sa-maw recipe extract in rats. MATERIAL AND METHOD: In the present study of acute toxicity, a single oral dose 5,000 mg/kg of Tri-sa-maw recipe extract was administered to rats.

Author(s): 
Nanna, Urarat
Jaijoy, Kanjana
Lertprasertsuke, Nirush
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Tithonia diversifolia (Hemsl.) A. Gray has been commonly used in folk medicine to treat abscesses, microbiological infections, snake bites, malaria and diabetes. Both anti-inflammatory and anti-malarial properties have been identified using appropriate assays, but the effective doses have demonstrated toxic effects for the experimental animals. Most of the pharmacological activities have been attributed to sesquiterpene lactones (STLs) and some chlorogenic acid derivatives (CAs) in the leaves of this species.

Author(s): 
Passoni, Flávia Donaire
Oliveira, Rejane Barbosa
Chagas-Paula, Daniela Aparecida
Gobbo-Neto, Leonardo
Da Costa, Fernando Batista
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