Trachea

Publication Title: 
Drugs Under Experimental and Clinical Research

Allergic rhinitis, also known as hay fever, rose fever or summer catarrh, is a major challenge to health professionals. A large number of the world's population, including approximately 40 million Americans, suffers from allergic rhinitis. A novel, botanical formulation (Aller-7) has been developed for the treatment of allergic rhinitis using a combination of extracts from seven medicinal plants, including Phyllanthus emblica, Terminalia chebula, T. bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale and P. longum, which have a proven history of efficacy and health benefits.

Author(s): 
Amit, A.
Saxena, V. S.
Pratibha, N.
D'Souza, P.
Bagchi, M.
Bagchi, D.
Stohs, S. J.
Publication Title: 
Cryobiology
Author(s): 
Thomford, N. R.
Wilson, W. H.
Blackburn, E. D.
Pace, W. G.
Publication Title: 
Archiv Der Pharmazie

The possibility of the preparation of some ester derivatives of dimethylxanthines from 1-theobromine- and 7-theophylline acetic acids and 7-(2-hydroxyethyl)-theophylline by DCC/DMAP-mediated esterification under mild conditions was studied. The structures of the compounds synthesized and by products isolated were demonstrated by microanalyses, UV-, IR-, and 1H NMR data. Acute toxicity assessment of the compounds on mice showed that compounds 4, 5, 6, and 7 are less toxic than aminophylline.

Author(s): 
Peikov, P.
Danchev, N.
Zlatkov, A.
Ivanov, D.
Belcheva, N.
Publication Title: 
The Journal of the Association of Physicians of India

Air flowing through a pipe exerts frictional stress on the walls of the pipe. Frictional stress of more than 40 N/m2 (velocity equivalent of air 113 m/s) is known to cause acute endothelial damage in blood vessels. The frictional stress in airways during coughing may be much greater, however, since the velocity of air may be as high as speed of sound in air. We suggest that high levels of frictional stress perpetuate airway inflammation in airways which are already inflamed and vulnerable to frictional stress-induced trauma in patients with asthma.

Author(s): 
Singh, V.
Chowdhary, R.
Chowdhary, N.
Publication Title: 
Journal of Ethnopharmacology

Swiss albino rats were treated in groups with CCl4, and flyash to induce cellular toxicity in the lungs and trachea. Animal groups received treatment of Koflet (K) with CCl4 (7 days) and with flyash (30 days); their general health and biochemical parameters were studied and used as an indication of cellular injuries. A significant loss was observed in body weight and food consumption in animals given only CCl4 or flyash, while simultaneous treatment with K resulted in a non significant alteration from normal control groups.

Author(s): 
Farooq, S.
Ahmad, I.
Pathak, G. K.
Publication Title: 
Journal of Herbal Pharmacotherapy

BACKGROUND AND OBJECTIVES: Curcuma caesia (family Zingiberaceae) is widely used in India as both an anti-inflammatory and anti-asthmatic in Ayurvedic medicine. However, there are no published pharmacological data on Curcuma caesia on its potential anti-asthmatic activity. Hence, the objective of the present investigation is to study the mechanisms by which the hydroalcoholic extract of Curcuma caesia relaxes the smooth muscle in the bronchioles and vasculature of the respiratory tract.

Author(s): 
Arulmozhi, D. K.
Sridhar, N.
Veeranjaneyulu, A.
Arora, S. K.
Publication Title: 
The Journal of the Association of Physicians of India

Air flowing through a pipe exerts frictional stress on the walls of the pipe. Frictional stress of more than 40 N/m2 (velocity equivalent of air 113 m/s) is known to cause acute endothelial damage in blood vessels. The frictional stress in airways during coughing may be much greater, however, since the velocity of air may be as high as speed of sound in air. We suggest that high levels of frictional stress perpetuate airway inflammation in airways which are already inflamed and vulnerable to frictional stress-induced trauma in patients with asthma.

Author(s): 
Singh, V.
Chowdhary, R.
Chowdhary, N.
Publication Title: 
American Journal of Respiratory and Critical Care Medicine

RATIONALE: Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection. OBJECTIVES: We hypothesized that airway epithelial cells from patients with COPD maintain a proinflammatory phenotype compared with control subjects, leading to greater RV responses. METHODS: Cells were isolated from tracheobronchial tissues of 12 patients with COPD and 10 transplant donors. Eight patients with COPD had severe emphysema, three had mild to moderate emphysema, and one had no emphysema.

Author(s): 
Schneider, Dina
Ganesan, Shyamala
Comstock, Adam T.
Meldrum, Catherine A.
Mahidhara, Raja
Goldsmith, Adam M.
Curtis, Jeffrey L.
Martinez, Fernando J.
Hershenson, Marc B.
Sajjan, Umadevi
Publication Title: 
Phytochemistry

Asthma is a serious health problem worldwide, particularly in industrialized countries. Despite a better understanding of the pathophysiology of asthma, there are still considerable gaps in knowledge as well as a need for classes of drugs. ASHMI™ (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao).

Author(s): 
Yang, Nan
Liang, Banghao
Srivastava, Kamal
Zeng, Jia
Zhan, Jixun
Brown, Laverne
Sampson, Hugh
Goldfarb, Joseph
Emala, Charles
Li, Xiu-Min
Publication Title: 
Journal of Pharmacological Sciences

Propolis is a bee product, which has long been used in folk medicine for the management of different diseases. In this study we evaluated the analgesic and anti-inflammatory effects of a standard ethanolic extract of Bulgarian propolis (Et-Blg) in mice and its in vitro effect on airway smooth muscle. Et-Blg inhibited acetic acid-induced abdominal contortions with an ID(50) = 7.4 +/- 0.7 mg. kg(-1). In the formalin test, the extract caused a significant reduction in pain in mice treated with 100 mg.

Author(s): 
Paulino, Niraldo
Dantas, Andreia Pires
Bankova, Vassya
Longhi, Daniela Taggliari
Scremin, Amarilis
de Castro, Solange Lisboa
Calixto, João Batista

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