transcription factor

Publication Title: 
Trends in genetics: TIG

Transcriptional mechanisms mediated by the binding of transcription factors (TFs) to cis-acting regulatory elements (CREs) in DNA play crucial roles in directing gene expression. While TFs have been extensively studied, less effort has gone towards the identification and functional characterization of CREs and associated epigenetic modulation. However, owing to methodological and analytical advances, more comprehensive studies of regulatory elements and mechanisms are now possible.

Author(s): 
Shibata, Mikihito
Gulden, Forrest O.
Sestan, Nenad
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