Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Fa2N-4 cells have been proposed as a tool to identify CYP3A4 inducers. To evaluate whether Fa2N-4 cells are a reliable surrogate for cryopreserved human hepatocytes, we assessed the basal mRNA expression of 64 drug disposition genes in Fa2N-4 cells. Significant differences were found in the expression of major drug-metabolizing enzymes, nuclear receptors, and transporters between both cell types.

Hariparsad, Niresh
Carr, Brian A.
Evers, Raymond
Chu, Xiaoyan
Publication Title: 

Withania somnifera (L.) is one of the most valuable medicinal plants used in Ayurvedic and other indigenous medicines. Pharmaceutical activities of this herb are associated with presence of secondary metabolites known as withanolides, a class of phytosteroids synthesized via mevalonate (MVA) and 2-C-methyl-D-erythritol-4-phosphate pathways. Though the plant has been well characterized in terms of phytochemical profiles as well as pharmaceutical activities, not much is known about the genes responsible for biosynthesis of these compounds.

Gupta, Parul
Agarwal, Aditya Vikram
Akhtar, Nehal
Sangwan, Rajender Singh
Singh, Surya Pratap
Trivedi, Prabodh Kumar
Publication Title: 
Hepatology (Baltimore, Md.)

Chronic inflammation plays a critical role in promoting obesity-related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation. We found that the accumulation of immature myeloid cells, i.e., CD11b(+)Ly6C(hi)Ly6G(-) cells, in the liver of B6 mice fed a high-fat diet contribute to liver inflammation.

Deng, Zhong-Bin
Liu, Yuelong
Liu, Cunren
Xiang, Xiaoyu
Wang, Jianhua
Cheng, Ziqiang
Shah, Spandan V.
Zhang, Shuangyin
Zhang, Liming
Zhuang, Xiaoying
Michalek, Sue
Grizzle, William E.
Zhang, Huang-Ge
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