Transforming Growth Factor beta1

Publication Title: 
Journal of the Science of Food and Agriculture

BACKGROUND: Persistent activation of hepatic stellate cells (HSC-T6) has been known to cause liver fibrosis. In this study, our objective was to investigate the effects of chebulagic acid and chebulinic acid, two hydrolysable tannins of tropical almond (Terminalia chebula) fruits, on collagen synthesis and signal transduction in transforming growth factor-?1-stimulated HSC-T6 cells.

Author(s): 
Chuang, Hsin-Ying
Ng, Lean-Teik
Lin, Liang-Tzung
Chang, Jung-San
Chen, Jen-Yang
Lin, Ta-Chen
Lin, Chun-Ching
Publication Title: 
IUBMB life

The current knowledge on the molecular mechanisms of the protective effect of calorie restriction (CR) against age-related fibrosclerosis is tentatively reviewed with specific reference to the role of oxidative stress in aging. The effects of oxidative stress are often mediated by its own final products. Of these, 4-hydroxy-2,3-nonenal (HNE) induces the expression and synthesis of transforming growth factor beta1 (TGFbeta1) and activates nuclear binding of transcription factor activator protein 1 (AP-1) thus stimulating fibrogenesis.

Author(s): 
Chiarpotto, Elena
Bergamini, Ettore
Poli, Giuseppe
Publication Title: 
The Tohoku Journal of Experimental Medicine

Myocardial infarction (MI) leads to progressive left ventricular (LV) dilatation and is associated with interstitial fibrosis in the non-infarcted myocardium. The NF-?B signaling pathway plays an important role in ventricular remodeling after MI. Recent studies have indicated that the anti-malarial agent artemisinin can inhibit NF-?B activation, which may attenuate post-infarct myocardial remodeling. In this study, we investigated the effect of artemisinin on post-infarct myocardial remodeling using a rat model of MI.

Author(s): 
Gu, Yongwei
Wang, Xi
Wang, Xin
Yuan, Mingjie
Wu, Gang
Hu, Juan
Tang, Yanhong
Huang, Congxin
Publication Title: 
The British Journal of Nutrition

The present study evaluated the antihypertrophic potential of the ethanolic extract of Boerhaavia diffusa (BDE), a well-known edible cardiotonic plant reported in Ayurveda against angiotensin II-induced hypertrophy in H9c2 cardiac myoblast cells. Markers of hypertrophy such as cell size, protein content and the concentrations of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) were analysed for the confirmation of hypertrophy induction.

Author(s): 
Prathapan, A.
Vineetha, V. P.
Abhilash, P. A.
Raghu, K. G.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Articular cartilage is an avascular, non-insulin-sensitive tissue that utilizes glucose as the main energy source, a precursor for glycosaminoglycan synthesis, and a regulator of gene expression. Facilitated glucose transport represents the first rate-limiting step in glucose metabolism. Previously, we demonstrated that glucose transport in chondrocytes is regulated by proinflammatory cytokines via upregulation of GLUT mRNA and protein expression.

Author(s): 
Shikhman, Alexander R.
Brinson, Diana C.
Lotz, Martin K.
Publication Title: 
Journal of Cellular Physiology

Transforming growth factor beta 1 (TGF-beta1) plays a key role in connective tissue remodeling, scarring, and fibrosis. The effects of mechanical forces on TGF-beta1 and collagen deposition are not well understood. We tested the hypothesis that brief (10 min) static tissue stretch attenuates TGF-beta1-mediated new collagen deposition in response to injury.

Author(s): 
Bouffard, Nicole A.
Cutroneo, Kenneth R.
Badger, Gary J.
White, Sheryl L.
Buttolph, Thomas R.
Ehrlich, H. Paul
Stevens-Tuttle, Debbie
Langevin, Helene M.
Publication Title: 
Clinical Immunology (Orlando, Fla.)

TGFbeta1 is considered to be required for peripheral maintenance of CD4(+)CD25(+)FOXP3(+) T(reg) cells. However, we demonstrate no reduction in the percentage of such T cells in the spleens and thymi of Tgfb1(-/-) mice. Although putative T(reg) cells, characterized as CD4(+)CD25(+)FOXP3(+)CD62L(+) T cells, are increased in Tgfb1(-/-) mice, they may be inadequate to control activated T cells since the ratio of activated T cells:putative T(reg) cells is several-fold higher in Tgfb1(-/-) mice than in control mice.

Author(s): 
Bommireddy, Ramireddy
Babcock, George F.
Singh, Ram R.
Doetschman, Thomas
Publication Title: 
Current Opinion in Rheumatology

PURPOSE OF REVIEW: Racial disparities appear to exist in the susceptibility and severity of systemic sclerosis (SSc, scleroderma) and are responsible for a greater health burden in blacks as compared with whites. Disparities in socioeconomic status and access to healthcare do not sufficiently explain the observed differences in prevalence and mortality. It is important to determine whether there might be a biologic basis for the racial disparities observed in SSc.

Author(s): 
Silver, Richard M.
Bogatkevich, Galina
Tourkina, Elena
Nietert, Paul J.
Hoffman, Stanley
Publication Title: 
PloS One

Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or non-infectious insult often leading to the development of intra-alveolar and interstitial fibrosis. Curcumin, the principal curcumoid of the popular Indian spice turmeric, has been demonstrated as an anti-oxidant and anti-inflammatory agent in a broad spectrum of diseases.

Author(s): 
Avasarala, Sreedevi
Zhang, Fangfang
Liu, Guangliang
Wang, Ruixue
London, Steven D.
London, Lucille
Publication Title: 
The Journal of Steroid Biochemistry and Molecular Biology

The inflammatory tissue microenvironment can be an active promoter in preneoplastic cancer lesions. Altered steroid hormone metabolism as induced by the inflammatory microenvironment may contribute to epithelial cancer progression. Dehydroepiandrosterone sulfate (DHEAS) is the most abundant endogenous steroid hormone present in human serum and can be metabolized to DHEA, androgens and/or estrogens in peripheral tissues. We have previously reported that TGFβ1-induced reactive prostate stromal cells increase DHEA metabolism to active androgens and alter prostate cancer cell gene expression.

Author(s): 
Piao, Yun-shang
Wiesenfeld, Paddy
Sprando, Robert
Arnold, Julia T.

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