Translational Medical Research

Publication Title: 
Current Psychiatry Reports

Anxiety disorders are highly prevalent and debilitating psychiatric disorders. Owing to the complex aetiology of anxiety disorders, translational studies involving multiple approaches, including human and animal genetics, molecular, endocrinological and imaging studies, are needed to get a converging picture of function or dysfunction of anxiety-related circuits.

Author(s): 
Erhardt, Angelika
Spoormaker, Victor I.
Publication Title: 
Translational Research: The Journal of Laboratory and Clinical Medicine

Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by the accumulation of amyloid ? peptides and abnormally phosphorylated tau proteins that are associated with cognitive decline and dementia. Much has been learned about the genomics of AD from linkage analyses and, more recently, genome-wide association studies. Several but not all aspects of the genomic landscape are involved in amyloid ? metabolism. The moderate concordance of disease among twins suggests other factors, potentially epigenomic factors, are related to AD.

Author(s): 
Bennett, David A.
Yu, Lei
Yang, Jingyun
Srivastava, Gyan P.
Aubin, Cristin
De Jager, Philip L.
Publication Title: 
Expert Opinion on Drug Discovery

INTRODUCTION: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task. AREAS COVERED: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group.

Author(s): 
Homberg, Judith R.
Kyzar, Evan J.
Stewart, Adam Michael
Nguyen, Michael
Poudel, Manoj K.
Echevarria, David J.
Collier, Adam D.
Gaikwad, Siddharth
Klimenko, Viktor M.
Norton, William
Pittman, Julian
Nakamura, Shun
Koshiba, Mamiko
Yamanouchi, Hideo
Apryatin, Sergey A.
Scattoni, Maria Luisa
Diamond, David M.
Ullmann, Jeremy F. P.
Parker, Matthew O.
Brown, Richard E.
Song, Cai
Kalueff, Allan V.
Publication Title: 
BMC medical ethics

BACKGROUND: Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel biomedical interventions. Overly optimistic portrayals of unproven interventions may influence public and patient expectations; the latter may cause patients to downplay risks and over-emphasize benefits, with implications for informed consent for clinical trials.

Author(s): 
Benjaminy, Shelly
Bubela, Tania
Publication Title: 
Global Heart

The CRONICAS Centre of Excellence in Chronic Diseases, based at Universidad Peruana Cayetano Heredia, was created in 2009 with support from the U.S. National Heart, Lung, and Blood Institute (NHLBI). The vision of CRONICAS is to build a globally recognized center of excellence conducting quality and innovative research and generating high-impact evidence for health. The center's identity is embedded in its core values: generosity, innovation, integrity, and quality.

Author(s): 
Miranda, J. Jaime
BernabÈ-Ortiz, Antonio
Diez-Canseco, Francisco
M·laga, Germ·n
Cardenas, MarÌa K.
Carrillo-Larco, Rodrigo M.
Pesantes, M. Amalia
Araya, Ricardo
Boggio, Oscar
Checkley, William
GarcÌa, Patricia J.
LeÛn-Velarde, Fabiola
Lescano, Andrés G.
Montori, Victor
Pan, William
Rivera-Chira, Maria
Sacksteder, Katherine
Smeeth, Liam
GarcÌa, HÈctor H.
Gilman, Robert H.
Publication Title: 
European journal of human genetics: EJHG

The promise of personalized medicine depends on the ability to integrate genetic sequencing information into disease risk assessment for individuals. As genomic sequencing technology enters the realm of clinical care, its scale necessitates answers to key social and behavioral research questions about the complexities of understanding, communicating, and ultimately using sequence information to improve health.

Author(s): 
Facio, Flavia M.
Brooks, Stephanie
Loewenstein, Johanna
Green, Susannah
Biesecker, Leslie G.
Biesecker, Barbara B.
Publication Title: 
The American Journal of Clinical Hypnosis

In a 2008 pilot study we used DNA microarrays to explore the historical ideo-plastic faculty of therapeutic hypnosis. We documented how to measure changes in activity or experience-dependent gene expression over relatively brief time periods (1 hour and 24 hours) following a single intervention of therapeutic hypnosis (about 1 hour). In the present paper we utilize bioinformatic software to explore the possible meaning and significance of this ideo-plastic faculty of therapeutic hypnosis.

Author(s): 
Atkinson, David
Iannotti, Salvatore
Cozzolino, Mauro
Castiglione, Stefano
Cicatelli, Angela
Vyas, Bhaskar
Mortimer, Jane
Hill, Richard
Chovanec, Erika
Chiamberlando, Alessia
Cuadros, Jorge
Virot, Claude
Kerouac, Michel
Kallfass, Thierry
Krippner, Stanley
Frederick, Claire
Gregory, Bruce
Shaffran, Michael
Bullock, Margaret
Soleimany, Ella
Rossi, April Cybelle
Rossi, Kathryn
Rossi, Ernest
Publication Title: 
Health Research Policy and Systems / BioMed Central

A major obstacle to the progress of the Millennium Development Goals has been the inability of health systems in many low- and middle-income countries to effectively implement evidence-informed interventions. This article discusses the relationships between implementation research and knowledge translation and identifies the role of implementation research in the design and execution of evidence-informed policy.

Author(s): 
Panisset, Ulysses
Koehlmoos, Tracey Pérez
Alkhatib, Ahmad Hamdi
Pantoja, Tomas
Singh, Prabal
Kengey-Kayondo, Jane
McCutchen, Ben
Publication Title: 
Pathologie-Biologie

Thanks to the sponsoring of Belgian Cancer Plan, we have launched a trans-hospital project of oncogeriatrics implying any concerned actors from medical (oncology, geriatrics, various specialties) and paramedical staffs (nurses, physiotherapists, ergotherapists, dieteticians, social workers, psychologists…). We aim to recruit 300 consecutive patients aged over 70 and presenting with a new diagnosed cancer. They will benefit from both detailed Comprehensive Geriatrical (CGA) and Oncological (COA) assessments.

Author(s): 
Focan, C.
Warzée, E.
Sondag, C.
Guillaume, T.
Publication Title: 
Archives of Biochemistry and Biophysics

Excessive exposure of the skin to solar ultraviolet (UV) radiation is one of the major factors for the development of skin cancers, including non-melanoma. For the last several centuries the consumption of dietary phytochemicals has been linked to numerous health benefits including the photoprotection of the skin. Green tea has been consumed as a popular beverage world-wide and skin photoprotection by green tea polyphenols (GTPs) has been widely investigated.

Author(s): 
Katiyar, Santosh K.

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