Methods for procurement, processing and distribution of allograft tissues have changed rapidly and many of the advances have resulted in widespread use of allograft tissues for reconstruction. However, unlike other types of orthopaedic implants, these human graft tissues are not simple commodities delivered to the surgeon or operating room in prepackaged sterile containers, but rather are more akin to gifts from a donor to a patient in need.
American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
The organ donor shortage has been the most important hindrance in getting listed patients transplanted. Living kidney donors who are incompatible with their intended recipients are an untapped resource for expanding the donor pool through participation in transplant exchanges. Chain transplantation takes this concept further, with the potential to benefit even more recipients.
Hypnosis was used to alter body image in an attempt to enable a woman to retain a skin homograft from an unrelated male donor. The man also acted as a nonhypnotized control by receiving a homograft from the hypnotized woman. Oneinch square full-thickness skin homografts were exchanged between the upper arms of the two volunteers. The homograft on the arm of the woman is still viable after eight months; the homograft on the man was rejected within two weeks.
Dipterocarpaceous plants contain various resveratrol oligomers that exhibit a variety of biological activities, such as antibacterial and antitumor effects. Previously, we found that vaticanol C, a resveratrol tetramer, exhibits strong cytotoxicity against various tumor cell lines. In the present study, we examined the antitumor activity of the ethanol extract from the stem bark of Vateria indica, which has been traditionally used for health and healing diseases as Ayurveda in India.
The Journal of Pharmacology and Experimental Therapeutics
Allogeneic hematopoietic cell transplantation (HCT) is widely used to treat patients with life-threatening malignant and nonmalignant hematological diseases. However, allogeneic HCT often is accompanied by severe and lethal complications from graft-versus-host disease (GVHD), in which activated donor T cells recognize histocompatibility antigenic mismatches and cause significant toxicity in the recipient. In the current study, we tested the hypothesis that activation of cannabinoid receptors on donor-derived T cells may prevent GVHD.
It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation.
An experience with functional and physical and physical therapy employed postoperatively in 525 patients with injuries of 752 digital flexor tendons is reported. A primary suture on flexor tendons after the V.I. Rozov technic within the boundaries of the synovial-aponeurotic sheath was put on 252 fingers in 183 patients. Homoplasty of digital flexor tendons was performed in 342 patients (500 fingers), terms of the injury being from 2 months to 15 years.
178 patients with various ligamental injuries were treated according to the technique elaborated at the Institute. To restore ligaments preserved tendon homografts from the long fibular tendon with a remained terminal bone fragment were employed. The techniques of Gay-Growth-Smith and Sitenko underlie the methods of tendinoplasty applied. Following the operation therapeutic exercises, using water basin, massage, mechanotherapy and different kinds of physical therapy were employed differentially. Good results were obtained in a vast majority of patients (91.6%).