Transplantation, Homologous

Publication Title: 
Journal of Translational Medicine

BACKGROUND: Immunological arguments and historical examples have shown that treatment with cord blood for non-hematopoietic activities, such as growth factor production and stimulation of angiogenesis, may not require matching or immune suppression. METHODS: To study the benefit of blood mononuclear cell therapy, 8 patients with idiopathic osteoporosis were given intermittent treatments with non-matched allogeneic cord blood mononuclear cells for 3 months.

Author(s): 
Li, Jun
Zhang, Li
Zhou, Liang
Yu, Zheng-Ping
Qi, Feng
Liu, Bei
Zi, Su-Xia
Li, Li
Li, Yi
Wang, San-Bin
Cui, Zheng-Jiang
Pan, Xing-Hua
Publication Title: 
Stem Cells and Development

Prenatal transplantation of genetically engineered mesenchymal stem cells (MSCs) might benefit prevention or treatment of early-onset genetic disorders due to the cells' intrinsic regenerative potential plus the acquired advantage from therapeutic transgene expression. However, a thorough assessment of the safety, accessibility, and behavior of these MSCs in the fetal environment using appropriate animal models is required before we can advance toward a clinical application.

Author(s): 
Moreno, Rafael
Martínez-González, Itziar
Rosal, Marta
Nadal, Marga
Petriz, Jordi
Gratacós, Eduard
Aran, Josep M.
Publication Title: 
Biology of Reproduction

Cryopreservation of testicular tissue can be used for ex situ conservation of male germplasm of avian species. The possibility of using vitrification and transplantation of testicular tissue for fertility preservation and recovery was tested in Japanese quail. Testes were removed from 1-wk-old Japanese quail; transfixed on acupuncture needles; equilibrated with dimethyl sulphoxide, ethylene glycol, and sucrose; plunged into liquid nitrogen; and stored in 2-ml straws. Cryopreserved tissue was warmed in sucrose solution at room temperature or at 40°C.

Author(s): 
Liu, Jianan
Cheng, Kimberly M.
Silversides, Frederick G.

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