Hypnosis was used to alter body image in an attempt to enable a woman to retain a skin homograft from an unrelated male donor. The man also acted as a nonhypnotized control by receiving a homograft from the hypnotized woman. Oneinch square full-thickness skin homografts were exchanged between the upper arms of the two volunteers. The homograft on the arm of the woman is still viable after eight months; the homograft on the man was rejected within two weeks.
PURPOSE OF REVIEW: Antibody-mediated rejection (AMR) is emerging as the leading cause of chronic rejection and allograft failure. Traditionally, the mechanisms of graft injury mediated by donor-specific antibodies beyond complement activation were not well appreciated. However, an evolving paradigm of Fc-independent antibody functions, along with clinical recognition of C4d-negative AMR, has increased awareness of the action of antibodies leading to endothelial activation and dysfunction.