Tremorine

Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

The effects of 1-[2-[bis (4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl) piperazine dihydrochloride (I-893) on the central nervous system were behaviorally and electroencephalographically investigated. Intraperitoneally injected I-893 (5-10 mg/kg) dose-dependently increased spontaneous motor activity in mice, but repeated injections did not affect the increase in the locomotor activity. In reserpinized mice, spontaneous motor activity was not increased by oral I-893.

Author(s): 
Nagase, T.
Hotta, K.
Morita, S.
Sakai, K.
Yamane, M.
Omote, M.
Mizusawa, H.
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