Triterpenes

Publication Title: 
Planta Medica

Phytochemical investigations of Terminalia arjuna bark and Terminalia chebula fruits resulted in the isolation of twelve triterpenoids including two new oleanane type triterpene glucosyl esters, ajunglucosides IV (1) and V (2), from the N-BuOH layer of the MeOH extract of T. arjuna bark as well as nine oleanane-type triterpenoids from the MeOH extract of the fruits of T. chebula.

Author(s): 
Wang, Wei
Ali, Zulfiqar
Li, Xing-Cong
Shen, Yunheng
Khan, Ikhlas A.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches. METHODS: Fifty-one ethanol extracts obtained from 44 different selected medicinal plant species were tested for resistance modifying agents (RMAs) of novobiocin against A. baumannii using growth inhibition assay.

Author(s): 
Phatthalung, Pinanong Na
Chusri, Sasitorn
Voravuthikunchai, Supayang P.
Publication Title: 
Planta Medica

Terminalia species are a rich source of tannins. Many preparations of these species are used in traditional medicine and have many different ethnobotanical applications. A simple UHPLC method was developed for the simultaneous analysis of such hydrolysable tannins and triterpene saponins from the fruit rinds of different species of Terminalia (T. chebula, T. arjuna, T. bellirica) and Phyllantus emblica. A separation by LC was achieved using a reversed-phase column and a water/acetonitrile mobile phase, both containing formic acid, using a gradient system and a temperature of 40°C.

Author(s): 
Avula, Bharathi
Wang, Yan-Hong
Wang, Mei
Shen, Yun-Heng
Khan, Ikhlas A.
Publication Title: 
Chemistry & Biodiversity

Nine phenolic compounds, including two phenolic carboxylic acids, 1 and 2, seven hydrolyzable tannins, 3-9, eight triterpenoids, including four oleanane-type triterpene acids, 10-13, and four of their glucosides, 14-17, isolated from a MeOH extract of the gall of Terminalia chebula Retz.

Author(s): 
Manosroi, Aranya
Jantrawut, Pensak
Ogihara, Eri
Yamamoto, Ayako
Fukatsu, Makoto
Yasukawa, Ken
Tokuda, Harukuni
Suzuki, Nobutaka
Manosroi, Jiradej
Akihisa, Toshihiro
Publication Title: 
Journal of Asian Natural Products Research

Two new triterpenoids, termichebuloside A (1), an unusual dimeric triterpenoid saponin, and termichebulolide (2), an oleanolic acid-type lactone, along with 11 known triterpenoids, were isolated from MeOH extract of the barks of Terminalia chebula. The structures of 1 and 2 were elucidated to be arjunglucoside I-(3-O-19',23-O-19')-18,19-seco-19-hydroxyarjunglucoside I (1) and 2?,3?,23-trihydroxyolean-11,13(18)-dien-28,19?-olide (2), respectively, on the basis of spectroscopic evidences and biogenetic consideration.

Author(s): 
Zhang, Chao
Jiang, Kun
Qu, Shi-Jin
Zhai, Yi-Ming
Tan, Jun-Jie
Tan, Chang-Heng
Publication Title: 
Bioorganic & Medicinal Chemistry Letters

Three new polyhydroxytriterpenoid derivatives, 23-O-neochebuloylarjungenin 28-O-?-d-glycopyranosyl ester (1), 23-O-4'-epi-neochebuloylarjungenin (2), and 23-O-galloylpinfaenoic acid 28-O-?-d-glucopyranosyl ester (17) were isolated from the fruits of Terminalia chebula Retz. along with fourteen known ones. Their structures were elucidated by 1D and 2D NMR spectroscopic data and acid hydrolysis.

Author(s): 
Lee, Dong Young
Yang, Heejung
Kim, Hyun Woo
Sung, Sang Hyun
Publication Title: 
Biological & Pharmaceutical Bulletin

Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We now showed that this combination also proved to be adequate in combating the formation of hyphae in vitro.

Author(s): 
Chang, Wenqiang
Li, Ying
Zhang, Li
Cheng, Aixia
Liu, Yongqing
Lou, Hongxiang
Publication Title: 
Annals of the New York Academy of Sciences

Dietary caloric restriction (CR) is the only intervention conclusively and reproducibly shown to slow aging and maintain health and vitality in mammals. Although this paradigm has been known for over 60 years, its precise biological mechanisms and applicability to humans remain unknown. We began addressing the latter question in 1987 with the first controlled study of CR in primates (rhesus and squirrel monkeys, which are evolutionarily much closer to humans than the rodents most frequently employed in CR studies).

Author(s): 
Roth, G. S.
Ingram, D. K.
Lane, M. A.
Publication Title: 
Planta Medica

The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultures of this species were established in order to induce a greater production of nor-friedelanes. The cell suspension line GgBa was selected and grown over a period of two years of continuous subculturing in MS nutrient medium in the absence of growth regulators.

Author(s): 
Ortíz, Anabel
Cardoso-Taketa, Alexandre
Monroy, Mario Rodríguez
Arellano, Jesús
Hernández, Georgina
Villarreal, María Luisa
Publication Title: 
Cell

Traditional medicines provide fertile ground for modern drug development, but first they must pass along a pathway of discovery, isolation, and mechanistic studies before eventual deployment in the clinic. Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin.

Author(s): 
Corson, Timothy W.
Crews, Craig M.

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