Tuberculosis

Publication Title: 
Journal of Intercultural Ethnopharmacology

BACKGROUND: Tuberculosis (TB) is a global public health crisis. 25% of world's TB cases are found in India. Ayurveda, an ancient medical science may offer some solution to this problem. Hence, a systematic review was carried out to assess the role of Ayurveda for the management of TB. METHODOLOGY: A systematic review was carried out using published literature obtained through "PubMed" until April 2015.

Author(s): 
Samal, Janmejaya
Publication Title: 
Computational Biology and Chemistry

Drug resistant tuberculosis has threatened all the advances that have been made in TB control at the global stage in the last few decades. DNA gyrase enzymes are an excellent target for antibacterial drug discovery as they are involved in essential functions like DNA replication. Here we report, a successful application of high throughput virtual screening (HTVS) to identify an inhibitor of Mycobacterium DNA gyrase targeting the wild type and the most prevalent three double mutants of quinolone resistant DNA gyrase namely A90V+D94G, A74S+D94G and A90V+S91P.

Author(s): 
Patel, Kunal
Tyagi, Chetna
Goyal, Sukriti
Jamal, Salma
Wahi, Divya
Jain, Ritu
Bharadvaja, Navneeta
Grover, Abhinav
Publication Title: 
Bulletin of the History of Medicine

In January 1952 a team of medical researchers from Cornell Medical College learned that tuberculosis raged untreated on the Navajo Reservation in Arizona. These researchers, led by Walsh McDermott, recognized a valuable opportunity for medical research, and they began a ten-year project to evaluate the efficacy of new antibiotics and test the power of modern medicine to improve the health conditions of an impoverished rural society. The history of this endeavor exposes a series of tensions at the heart of medical research and practice.

Author(s): 
Jones, David S.
Publication Title: 
African Health Sciences

The current global tuberculosis (TB) epidemic has pressured health care managers, particularly in developing countries, to seek for alternative, innovative ways of delivering effective treatment to the large number of TB patients diagnosed annually. One strategy employed is direct observation of treatment (DOT) for all patients. In high-burden settings innovation with this strategy has resulted into the use of lay community members to supervise TB patients during the duration of anti-TB treatment. However, community involvement in health programmes is not a simple matter.

Author(s): 
Kironde, Samson
Bajunirwe, Francis
Publication Title: 
The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease

The World Health Organization and the Revised National TB Control Programme (RNTCP) in India have advocated public-private mix as essential for tuberculosis (TB) control. We conducted a cross-sectional sample survey of private providers (with various qualifications) in Ujjain District, India, to study willingness and motivation to collaborate. Most providers were aware of the RNTCP and had referred patients there. All were willing to collaborate, although the areas for collaboration varied between urban and rural providers.

Author(s): 
De Costa, A.
Kazmi, T.
Lˆnnroth, K.
Uplekar, M.
Diwan, V. K.
Publication Title: 
The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease

SETTING: Since 2005, private pharmacies linked to the National Tuberculosis Programme (NTP) and the Municipal Health Department in Phnom Penh have referred tuberculosis (TB) symptomatic patients to public sector TB clinics. OBJECTIVE: To investigate the attitudes and practices of pharmacy-initiated referral service providers in Phnom Penh from 2005 to 2010. METHODS: In a qualitative study, participants were purposively selected from the register of pharmacy owners providing referral services. Discussions were conducted in Khmer by trained facilitators.

Author(s): 
Bell, C. A.
Eang, M. T.
Dareth, M.
Rothmony, E.
Duncan, G. J.
Saini, B.
Publication Title: 
The Medical Press
Author(s): 
Atkin, I.
Publication Title: 
Journal of Natural Products

Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico.

Author(s): 
León-Rivera, Ismael
Mirón-López, Gumersindo
Molina-Salinas, Gloria María
Herrera-Ruiz, Maribel
Estrada-Soto, Samuel
del Carmen Gutiérrez, María
Alonso-Cortes, Daniel
Navarrete-Vázquez, Gabriel
Rios, María Yolanda
Said-Fernández, Salvador
Publication Title: 
Emerging Infectious Diseases

Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria. Recent declines in the clinical effectiveness of antimalarial drugs, including artemisinin-based combination therapy, have prompted the need to revise the definitions of and/or to recategorize antimalarial drug resistance to include extensively drug-resistant malaria.

Author(s): 
Wongsrichanalai, Chansuda
Varma, Jay K.
Juliano, Jonathan J.
Kimerling, Michael E.
MacArthur, John R.
Publication Title: 
Journal of the American Chemical Society

Although the antimalarial agent artemisinin itself is not active against tuberculosis, conjugation to a mycobacterial-specific siderophore (microbial iron chelator) analogue induces significant and selective antituberculosis activity, including activity against multi- and extensively drug-resistant strains of Mycobacterium tuberculosis. The conjugate also retains potent antimalarial activity.

Author(s): 
Miller, Marvin J.
Walz, Andrew J.
Zhu, Helen
Wu, Chunrui
Moraski, Garrett
Möllmann, Ute
Tristani, Esther M.
Crumbliss, Alvin L.
Ferdig, Michael T.
Checkley, Lisa
Edwards, Rachel L.
Boshoff, Helena I.

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