Tumor Necrosis Factor-alpha

Publication Title: 
Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

BACKGROUND: Cystatin C (cC) is a cysteine protease inhibitor that may influence immune response. Our aim was to test the effect of a high concentration of cC, characteristic for uremic patients, on neutrophil (PMN) apoptosis and respiratory burst, as well as the cC secretion from PMNs stimulated with proinflammatory cytokines. MATERIAL/METHODS: PMNs from 35 healthy volunteers aged 27-61 years were cultured in presence of cC, IL-1beta or TNF-alpha. The percentage of apoptotic cells based on DNA depletion, Fas, FasL and caspase -3 expression were assessed.

Author(s): 
Majewska, Ewa
Wittek, Natalia
Rysz, Jacek
Baj, Zbigniew
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

One of the most robust observations in the biology of aging is that caloric restriction (CR) extends life in a variety of species. Although CR results in a severalfold decrease in fat mass (FM), the role of fat on life extension was considered to be minimal. Two main reasons accounted for this belief. First, although increased FM is associated with changes in substrate oxidation and in glucose homeostasis, in part through the effects of free fatty acids (FFA) and glycerol, several studies have suggested that longevity is determined independent of FM.

Author(s): 
Barzilai, N.
Gupta, G.
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

GLUT-4 (glucose transporter) receptor, tumor necrosis factor-alpha (TNF-alpha), interleukins-6 (IL-6), daf-genes and PPARs (peroxisomal proliferation activator receptors) play a role in the development of insulin resistance syndrome and associated conditions. But, the exact interaction between these molecules/factors and the mechanism(s) by which they produce insulin resistance syndrome is not clear.

Author(s): 
Das, Undurti N.
Publication Title: 
Clinical chemistry and laboratory medicine: CCLM / FESCC

BACKGROUND: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects. METHODS: Within the ZINCAGE study, 957 healthy old subjects (>or=60 years old) from five European countries were recruited.

Author(s): 
Dedoussis, George V.
Kanoni, Stavroula
Mariani, Erminia
Cattini, Luca
Herbein, Georges
Fulop, Tamas
Varin, Audrey
Rink, Lothar
Jajte, Jolanta
Monti, Daniela
Marcellini, Fiorela
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
PloS One

Caloric restriction (CR) extends lifespan through a reduction in oxidative stress, delays the onset of morbidity and prolongs lifespan. We previously reported that long-term CR hastened clinical onset, disease progression and shortened lifespan, while transiently improving motor performance in G93A mice, a model of amyotrophic lateral sclerosis (ALS) that shows increased free radical production.

Author(s): 
Patel, Barkha P.
Safdar, Adeel
Raha, Sandeep
Tarnopolsky, Mark A.
Hamadeh, Mazen J.
Publication Title: 
Biochemistry. Biokhimii?a

Negative factors, such as the "magnificent" five that includes alcoholism, smoking, unhealthy food, lack of movement, and negative emotions, accompany a person almost from birth and trigger powerful internal biochemical reactions leading to disastrous consequences. Those new deleterious reactions force the organism to mobilize all of its internal reserves to neutralize, at least temporarily, the destructive effects of these negative factors.

Author(s): 
Rzheshevsky, A. V.
Publication Title: 
PloS One

BACKGROUND: Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction.

Author(s): 
O'Donovan, Aoife
Pantell, Matthew S.
Puterman, Eli
Dhabhar, Firdaus S.
Blackburn, Elizabeth H.
Yaffe, Kristine
Cawthon, Richard M.
Opresko, Patricia L.
Hsueh, Wen-Chi
Satterfield, Suzanne
Newman, Anne B.
Ayonayon, Hilsa N.
Rubin, Susan M.
Harris, Tamara B.
Epel, Elissa S.
Health Aging and Body Composition Study
Publication Title: 
PloS One

BACKGROUND: Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction.

Author(s): 
O'Donovan, Aoife
Pantell, Matthew S.
Puterman, Eli
Dhabhar, Firdaus S.
Blackburn, Elizabeth H.
Yaffe, Kristine
Cawthon, Richard M.
Opresko, Patricia L.
Hsueh, Wen-Chi
Satterfield, Suzanne
Newman, Anne B.
Ayonayon, Hilsa N.
Rubin, Susan M.
Harris, Tamara B.
Epel, Elissa S.
Health Aging and Body Composition Study
Publication Title: 
Psychological Medicine

BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. METHOD: We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ).

Author(s): 
Dennison, U.
McKernan, D.
Cryan, J.
Dinan, T.
Publication Title: 
Journal of Managed Care & Specialty Pharmacy

BACKGROUND: Introduction of biologic disease-modifying antirheumatic drugs (DMARDs) has revolutionized treatment in patients with rheumatoid arthritis (RA). However, due to substantially higher costs of biologics compared with nonbiologics, patients with less insurance generosity may have difficulty affording these agents, which may lead to potential access disparities. OBJECTIVE: To identify factors affecting treatment initiation with tumor necrosis factor (TNF)-? inhibitor biologics in patients with RA.

Author(s): 
Desai, Rishi J.
Rao, Jaya K.
Hansen, Richard A.
Fang, Gang
Maciejewski, Matthew L.
Farley, Joel F.

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