Tyrosine 3-Monooxygenase

Publication Title: 
Journal of Neurochemistry

The human tyrosine hydroxylase (hTH) gene has a 42†bp evolutionarily conserved region designated (CR) II at -7.24†kb, which bears 93% homology to the region we earlier identified as containing the glucocorticoid response element, a 7†bp activator protein-1 (AP-1)-like motif in the rat TH gene. We cloned this hTH-CRII region upstream of minimal basal hTH promoter in luciferase (Luc) reporter vector, and tested glucocorticoid responsiveness in human cell lines.

Author(s): 
Sheela Rani, C. S.
Soto-Pina, Alexandra
Iacovitti, Lorraine
Strong, Randy
Publication Title: 
Pharmacology

The hypnosis and hypothermia induced by phenobarbitone (100 mg/kg i.p.) were greatly potentiated by combined treatment with alpha-methylparatyrosine (alpha-MPT, 250 mg/kg i.p.). alpha-MPT per se produced sedation and hypothermia. Measurement of blood and brain levels of phenobarbitone in rats treated with phenobarbitone alone or phenobarbitone plus alpha-MPT revealed that the latter delayed the disappearance rates of phenobarbitone from both brain and plasma. These results suggest an interaction at the site of distribution, metabolism and/or excretion of phenobarbitone.

Author(s): 
Elhwuegi, A. S.
Publication Title: 
Pharmacology, Biochemistry, and Behavior

The classical benzodiazepine diazepam (DZ) induces anxiolysis at low doses and sedation and hypnosis at higher doses. Different brain areas and neuronal populations most likely mediate these different behavioral effects. We used c-Fos immunohistochemistry as an indirect way to study neuronal activation or inhibition induced by DZ at anxiolytic and sedative doses (0.5 and 5mg/kg, respectively) in various brain areas involved in anxiety, arousal, sedation and addiction in C57BL/6J mice.

Author(s): 
Panhelainen, Anne E.
Korpi, Esa R.
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Neurochemical Research

Aging is characterized by development of diseases and cancer due to loss of central and peripheral neuroendocrine-immune responses. Free radicals exert deleterious effects on neural-immune functions in the brain, heart, and lymphoid organs and thus, affecting the health. Bacopa monnieri (brahmi), an Ayurvedic herb, and L-deprenyl, a monoamine oxidase-B inhibitor, have been widely used in the treatment of neurodegenerative diseases.

Author(s): 
Priyanka, Hannah P.
Bala, Preetam
Ankisettipalle, Sindhu
ThyagaRajan, Srinivasan
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

The purpose of this study was to examine cardiovascular responses to fourth cerebral ventricle (4V) administration of nitroglycerin (NTG) or an inhibitor of nitric oxide (NO) synthase (NOS) in the near-term ovine and to determine whether, during birth, neuronal NOS (nNOS) is induced in noradrenergic A1 neurons in the medial nucleus tractus solitarius (mNTS). In chronically instrumented fetal sheep, 4V injection of NTG (1.2 nmol), an NO donor, produced an arterial blood depressor and a moderate decrease in heart rate.

Author(s): 
Ma, Sheng-Xing
Fang, Qun
Morgan, Brian
Ross, Michael G.
Chao, Conrad R.
Publication Title: 
Brain Research

Chronic morphine administration induces functional and morphological alterations in the mesolimbic dopamine system (MLDS), which is believed to be the neurobiological substrate of opiate addiction. Our previous studies have demonstrated that peripheral electrical stimulation (PES) can suppress morphine withdrawal syndrome and morphine-induced conditioned place preference (CPP) in rats. The present study was designed to investigate if PES could reverse the cell size reduction induced by chronic morphine treatment in the ventral tegmental area (VTA), which is an important area of the MLDS.

Author(s): 
Chu, Ning-Ning
Zuo, Yan-Fang
Meng, Li
Lee, David Yue-Wei
Han, Ji-sheng
Cui, Cai-Lian
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Experimental Gerontology

We examined if life-long mild caloric restriction (CR) alone or with voluntary exercise prevents the age-related changes in catecholamine biosynthetic enzyme levels in the adrenal medulla and hypothalamus. Ten-week-old Fisher-344 rats were assigned to: sedentary; sedentary+8% CR; or 8% CR+wheel running. Rats were euthanized at 6 or 24 months of age. Tyrosine hydroxylase (TH) mRNA expression was 4.4-fold higher in the adrenal medullae and 60% lower in the hypothalamus of old sedentary rats compared to young (p<0.01).

Author(s): 
Erdös, Benedek
Broxson, Christopher S.
Landa, Tessa
Scarpace, Philip J.
Leeuwenburgh, Christiaan
Zhang, Yi
Tümer, Nihal

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