Ultraviolet Rays

Publication Title: 
BMJ clinical evidence

INTRODUCTION: Psoriasis affects 1-3% of the population, in some people causing changes to the nails and joints in addition to skin lesions. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of systemic drug treatments, topical drug treatments, and non-drug treatments (other than ultraviolet light) for chronic plaque psoriasis? What are the effects of ultraviolet light treatments for chronic plaque psoriasis?

Author(s): 
Naldi, Luigi
Rzany, Berthold
Publication Title: 
BMJ clinical evidence

INTRODUCTION: Psoriasis affects 1-3% of the population, in some people causing changes to the nails and joints in addition to skin lesions. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of systemic drug treatments, topical drug treatments, and non-drug treatments (other than ultraviolet light) for chronic plaque psoriasis? What are the effects of ultraviolet light treatments for chronic plaque psoriasis?

Author(s): 
Naldi, Luigi
Rzany, Berthold
Publication Title: 
Phytotherapy research: PTR

The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 +/- 3.8% at a concentration of 50 microg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage.

Author(s): 
Na, MinKyun
Bae, KiHwan
Kang, Sam Sik
Min, Byung Sun
Yoo, Jae Kuk
Kamiryo, Yuko
Senoo, Yu-ichiro
Yokoo, Seiichi
Miwa, Nobuhiko
Publication Title: 
Pharmaceutical Biology

CONTEXT: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. OBJECTIVE: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. MATERIALS AND METHODS: The viability of human skin fibroblasts after incubation with T.

Author(s): 
Yakaew, Swanya
Itsarasook, Khwunjit
Ngoenkam, Jatuporn
Jessadayannamaetha, Arum
Viyoch, Jarupa
Ungsurungsie, Malyn
Publication Title: 
Molecular and Cellular Biology

SIRT3 is a member of the Sir2 family of NAD(+)-dependent protein deacetylases that promotes longevity in many organisms. The processed short form of SIRT3 is a well-established mitochondrial protein whose deacetylase activity regulates various metabolic processes. However, the presence of full-length (FL) SIRT3 in the nucleus and its functional importance remain controversial. Our previous studies demonstrated that nuclear FL SIRT3 functions as a histone deacetylase and is transcriptionally repressive when artificially recruited to a reporter gene.

Author(s): 
Iwahara, Toshinori
Bonasio, Roberto
Narendra, Varun
Reinberg, Danny
Publication Title: 
American Journal of Physical Anthropology

The ancestral state of human skin pigmentation evolved in response to high ultraviolet radiation (UVR) stress. Some argue that pigmentation evolved to limit folate photolysis, therein limiting neural tube defects. Pigmentation also protects against sunburn which decreases the efficiency of sweating and potentiates skin infection. Pigmentation increases the efficacy of skin as a barrier to infection. Skin cancer has been rejected or minimized as a selective pressure because it is believed to have little or no effect on mortality during reproductive years.

Author(s): 
Osborne, Daniel L.
Hames, Raymond
Publication Title: 
American Journal of Epidemiology

Geographic variations in mortality rate in the United States could be due to several hypothesized factors, one of which is exposure to solar ultraviolet radiation (UVR). Limited evidence from previous prospective studies has been inconclusive. The association between ambient residential UVR exposure and total and cause-specific mortality risks in a regionally diverse cohort (346,615 white, non-Hispanic subjects, 50-71 years of age, in the National Institutes of Health (NIH)-AARP Diet and Health Study) was assessed, with accounting for individual-level confounders.

Author(s): 
Lin, Shih-Wen
Wheeler, David C.
Park, Yikyung
Spriggs, Michael
Hollenbeck, Albert R.
Freedman, D. Michal
Abnet, Christian C.
Publication Title: 
Blood

The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is unknown. Although genetic alterations have been identified, none are considered consistently causative in MF. To identify potential drivers of MF, we performed whole-genome sequencing of MF tumors and matched normal skin. Targeted ultra-deep sequencing of MF samples and exome sequencing of CTCL cell lines were also performed. Multiple mutations were identified that affected the same pathways, including epigenetic, cell-fate regulation, and cytokine signaling, in MF tumors and CTCL cell lines.

Author(s): 
McGirt, Laura Y.
Jia, Peilin
Baerenwald, Devin A.
Duszynski, Robert J.
Dahlman, Kimberly B.
Zic, John A.
Zwerner, Jeffrey P.
Hucks, Donald
Dave, Utpal
Zhao, Zhongming
Eischen, Christine M.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Turmeric (the rhizomes of Curcuma longa L., Zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in Ayurvedic, Unani and Chinese medicine. Although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. The aim of this study was to clarify whether turmeric prevents chronic ultraviolet B (UVB)-irradiated skin damage.

Author(s): 
Sumiyoshi, Maho
Kimura, Yoshiyuki
Publication Title: 
Science (New York, N.Y.)

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a "BH3-domain-only" BCL-2 family member, triggers the homooligomerization of "multidomain" conserved proapoptotic family members BAK or BAX, resulting in the release of cytochrome c from mitochondria. We find that cells lacking both Bax and Bak, but not cells lacking only one of these components, are completely resistant to tBID-induced cytochrome c release and apoptosis.

Author(s): 
Wei, M. C.
Zong, W. X.
Cheng, E. H.
Lindsten, T.
Panoutsakopoulou, V.
Ross, A. J.
Roth, K. A.
MacGregor, G. R.
Thompson, C. B.
Korsmeyer, S. J.

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