Urine

Publication Title: 
Mechanisms of Ageing and Development

It has been hypothesized that the deamidation of glutaminyl and asparaginyl residues serves as a molecular clock for many biological processes including protein turnover, development, and aging. At present, this hypothesis has passed some experimental tests which are necessary but not sufficient for its acceptance. The current state of evidence about deamidation as a molecular clock is discussed.

Author(s): 
Robinson, A. B.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether is an efficacious antimalarial drug that also displays antischistosomal properties. Laboratory studies have found that artemether curtails the development of adult worms of Schistosoma japonicum, S. mansoni and S. haematobium, and thus prevents morbidity. These findings have been confirmed in clinical trials for the former two parasites; administered orally once every 2-3 weeks, artemether significantly reduced the incidence and intensity of patent infections. Here, we present the first randomized, double-blind, placebo-controlled trial of artemether against S.

Author(s): 
N'Goran, Eliézer K.
Utzinger, Jürg
Gnaka, Henri N.
Yapi, Ahoa
N'Guessan, Nicaise A.
Kigbafori, Silué D.
Lengeler, Christian
Chollet, Jacques
Shuhua, Xiao
Tanner, Marcel
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Heme alkylation by the antimalarial drug artemisinin is reported in vivo, within infected mice that have been treated at pharmacologically relevant doses. Adducts resulting from the alkylation of heme by the drug were characterized in the spleen of treated mice, and their glucuroconjugated derivatives were present in the urine. Because these heme-artemisinin adducts were not observed in noninfected mice, this report confirms that the alkylating activity of this antimalarial drug is related to the presence of the parasite in infected animals.

Author(s): 
Robert, Anne
Benoit-Vical, Françoise
Claparols, Catherine
Meunier, Bernard
Publication Title: 
Physiology & Behavior

The aim of this work was to study the influence of the hormonal milieu on the facilitory effects of olfactory stimuli originating from female urine on lordosis behavior in orchidectomized (ORCH) feminized rats. Urine from ovariectomized (OVX) rats was shown to increase the proportion of ORCH rats displaying lordosis behavior, an effect which was enhanced if the OVX rats had been given progesterone. Treatment of OVX rats with estradiol benzoate did not affect the pheromonal activity of their urine.

Author(s): 
Schaeffer, C.
Aron, C.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial. Ayurveda advocates that nux vomica seeds are to be administered in therapeutics only after going through certain purificatory measures (Shodhana).

Author(s): 
Mitra, Swarnendu
Shukla, V. J.
Acharya, Rabinarayan
Publication Title: 
The Ceylon Medical Journal

OBJECTIVE: To investigate the diuretic, natriuretic and kaliuretic effects of the antihypertensive Ayurveda drug Karavi Panchaka decoction and compare it with the diuretic frusemide. DESIGN: An animal study using Sprague-Dawley rats. The volume of urine and the total sodium and potassium excreted in the urine by rats in response to orally fed Karavi Panchaka decoction were compared with rats fed with frusemide. Control experiments were done with rats receiving similar volumes of distilled water orally.

Author(s): 
Welihinda, Jayantha
Ariyawansa, H. a. S.
Wickramasinghe, Rohitha
Publication Title: 
Journal of AOAC International

Presently, disulfiram is used in aversion therapy for recovering alcoholics. It acts by inhibiting aldehyde dehydrogenase, leading to high blood levels of acetaldehyde. A simple direct injection micellar liquid chromatographic procedure was developed to determine disulfiram in illicit preparations (ayurvedic, herbal, divine ash, and traditional medicine), as well as in pharmaceuticals and biological samples (urine).

Author(s): 
Mourya, Sandeep-Kumar
Dubey, Swati
Durgabanshi, Abhilasha
Shukla, Sudheer Kumar
Esteve-Romero, Josep
Bose, Devasish
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial. Ayurveda advocates that nux vomica seeds are to be administered in therapeutics only after going through certain purificatory measures (Shodhana).

Author(s): 
Mitra, Swarnendu
Shukla, V. J.
Acharya, Rabinarayan
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Lauha bhasma (iron ash) is one of the iron-based herbo-metallic preparations used in Ayurvedic medicine for treating various ailments due to iron deficiency. MATERIALS AND METHODS: The preparation of Lauha bhasma (iron ash) requires normal purification (heat treatment in vegetable and animal products), special purification (treatment with herbal constituents) and calcination steps aimed at converting the raw material to a suitable therapeutic form.

Author(s): 
Krishnamachary, Balaji
Rajendran, Narendran
Pemiah, Brindha
Krishnaswamy, Sridharan
Krishnan, Uma Maheswari
Sethuraman, Swaminathan
Sekar, Rajan K.
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

In the present study, rapid resolution liquid chromatography was coupled with quadrupole time-of-flight tandem mass spectrometry (RRLC-Q-TOF-MS) to identify the absorbed components and metabolites in rat urine after oral administration of Buyang Huanwu decoction (BYHWD). After oral administration of BYHWD, urine samples were collected and pretreated by solid phase extraction.

Author(s): 
Wen, Xiao-Dong
Liu, E.-Hu
Yang, Jie
Li, Chang-Yin
Gao, Wen
Qi, Lian-Wen
Wang, Chong-Zhi
Yuan, Chun-Su
Li, Ping

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