Vaccines, Attenuated

Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Sterile protection against malaria infection can be achieved through vaccination of mice and humans with whole Plasmodium spp. parasites. One such method, known as infection-treatment-vaccination (ITV), involves immunization with wild type sporozoites (spz) under drug coverage.

Author(s): 
Peng, Xiaohong
Keitany, Gladys J.
Vignali, Marissa
Chen, Lin
Gibson, Claire
Choi, Kimberly
Huang, Fusheng
Wang, Ruobing
Publication Title: 
Vaccine

We examined rotavirus-specific IFN-gamma producing CD4+, CD8+ and CD4+CD8+ T cell responses in gnotobiotic pigs infected with a virulent human rotavirus (VirHRV) or vaccinated with an attenuated (Att) HRV vaccine (AttHRV3x or AttHRV2x) or an AttHRV oral priming and 2/6-virus-like particle (VLP) intranasal boosting (AttHRV-2/6VLP) regimen. In VirHRV infected pigs, HRV-specific IFN-gamma producing T cells reside primarily in ileum. AttHRV-2/6VLP induced similar frequencies of intestinal IFN-gamma producing T cells as the VirHRV, whereas AttHRV3x or 2x vaccines were less effective.

Author(s): 
Yuan, Lijuan
Wen, Ke
Azevedo, Marli S. P.
Gonzalez, Ana M.
Zhang, Wei
Saif, Linda J.
Publication Title: 
Vaccine

We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-gamma producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization.

Author(s): 
Zhang, Wei
Azevedo, Marli S. P.
Wen, Ke
Gonzalez, Ana
Saif, Linda J.
Li, Guohua
Yousef, Ahmed E.
Yuan, Lijuan
Publication Title: 
European Journal of Clinical Nutrition

BACKGROUND/OBJECTIVES: Live-attenuated influenza vaccine (LAIV) protects against influenza by mucosal activation of the immune system. Studies in animals and adults have demonstrated that probiotics improve the immune response to mucosally delivered vaccines. We hypothesized that Lactobacillus GG (LGG) would function as an immune adjuvant to increase rates of seroconversion after LAIV administration. SUBJECTS/METHODS: We conducted a randomized double-blind placebo-controlled pilot study to determine whether LGG improved rates of seroconversion after administration of LAIV.

Author(s): 
Davidson, L. E.
Fiorino, A.-M.
Snydman, D. R.
Hibberd, P. L.
Publication Title: 
Vaccine

Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (Bb12) with/without col/milk (mimicking breast/formula fed infants) on B lymphocyte responses to an attenuated (Att) human rotavirus (HRV) Wa strain vaccine in a neonatal gnotobiotic pig model.

Author(s): 
Chattha, Kuldeep S.
Vlasova, Anastasia N.
Kandasamy, Sukumar
Esseili, Malak A.
Siegismund, Christine
Rajashekara, Gireesh
Saif, Linda J.
Subscribe to RSS - Vaccines, Attenuated