Vas Deferens

Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

Effects of ifenprodil tartrate, a potent vasodilator, on the autonomic, peripheral and central nerve system were studied in experimental animals. In isolated vas deferens of guinea pigs, the contraction in response to noradrenaline and sympathetic nerve stimulation was competetively antagonized by ifenprodil 10(-7)--10(-5) M (pA2: 7.69 against noradrenaline). Ifenprodil (50 approximately 1,000 mug/kg i.v.) inhibited the contraction of cat nictitating membrane and dog urinary bladder induced by sympathetic nerve stimulation.

Author(s): 
Mizusawa, H.
Yamane, M.
Sakai, K.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

Calcification of the vas deferens may be associated with diabetes mellitus. This paper discusses the case of a patient in which this occurred. In clinical practice, this radiological finding may indicate further diagnostic workup for diabetes or other causative conditions which are described here.

Author(s): 
Tsuno, M. M.
Gerber, J. M.
Pokras, R. S.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

(E)-Methyl 2-((2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (7-hydroxymitragynine), a main active constituent of the traditional herbal medicine Mitragyna speciosa, is an indole alkaloid that is structurally different from morphine. 7-Hydroxymitragynine induces a potent antinociceptive effect on mouse acute pain through μ-opioid receptors. In this study, we developed dual-acting μ- and δ-opioid agonists MGM-15 and MGM-16 from 7-hydroxymitragynine for the treatment of acute and chronic pain.

Author(s): 
Matsumoto, Kenjiro
Narita, Minoru
Muramatsu, Naotaka
Nakayama, Terumi
Misawa, Kaori
Kitajima, Mariko
Tashima, Kimihito
Devi, Lakshmi A.
Suzuki, Tsutomu
Takayama, Hiromitsu
Horie, Syunji
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