Vasodilator Agents

Publication Title: 
Archives of Physical Medicine and Rehabilitation

OBJECTIVES: To present an evidence-based overview of the effectiveness of (non)surgical symptomatic interventions to treat secondary Raynaud's phenomenon (RP). DATA SOURCES: The Cochrane Library, PubMed, Embase, PEDro, and CINAHL were searched for relevant systematic reviews and randomized controlled trials (RCTs). STUDY SELECTION: Two reviewers independently applied the inclusion criteria to select potential studies. DATA EXTRACTION: Two reviewers independently extracted data and assessed the methodologic quality.

Author(s): 
Huisstede, Bionka M.
Hoogvliet, Peter
Paulis, Winifred D.
van Middelkoop, Marienke
Hausman, Michael
Coert, J. Henk
Koes, Bart W.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

Pharmacological effects of ifenprodil (IP), 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol-L-(+)-tartrate monohydrate (Funai Pharmaceutical), a potential vasodilator, were studied in the dog, rabbit, guinea-pig and mouse. 1) Intravenous administration of IP (0.1 approximately 1 mg/kg) exhibited a continuous fall in blood pressure, an increase in heart rate and an increase in cardiac contractile force in the dog. The depressor and chronotropic effects of IP appeared likewise in the pithed dog, and the depressor responses were slightly more evident in the rabbit.

Author(s): 
Maeda, Y.
Furukawa, T.
Publication Title: 
Arzneimittel-Forschung

The pharmacological effects of the new platelet aggregation inhibitor cilostazol (6-(4-(1-cyclohexyl-1 H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC-13013) on the central nervous system were studied. Cilostazol had little effect on the general behavior of mice up to a dose of 1000 mg/kg p.o. and caused disappearance of pinna reflex, alertness and startle response and slight ptosis in only one of 6 rats at a dose of 1000 mg/kg p.o.

Author(s): 
Shintani, S.
Toba, Y.
Suzuki, S.
Ninomiya, S.
Umezato, M.
Hiyama, T.
Publication Title: 
Arzneimittel-Forschung

Pharmacological effects of a new vasodilator, flosequinan (7-fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolone, BTS 49 465, CAS 76568-02-0) on the central nervous system, somatic nervous system, autonomic nervous system and smooth muscle, digestive system and miscellaneous organs were investigated. 1. The central nervous system: Flosequinan inhibited acetic acid-induced writhing at doses of more than 30 mg/kg p.o. and decreased body temperature and tended to decrease spontaneous movement slightly in mice at a dose of 100 mg/kg p.o.

Author(s): 
Ikezono, K.
Fujita, S.
Umezato, M.
Hosoki, E.
Toba, Y.
Kusunoki, A.
Shintani, S.
Publication Title: 
HNO

Two groups of tinnitus patients (n=93) were recruited, one of which was treated with standard infusion therapy and further acute medical intervention, while the other obtained an additional psychotherapeutic intervention. Questionnaires and interviews were taken at beginning of the treatment, and 9 days and 3 years after treatment. The accompanying psychotherapeutic intervention consisted primarily of client-centered counseling, guided relaxation techniques from clinical hypnosis, and some standard and tinnitus-related methods for a better coping with stress.

Author(s): 
Schildt, A.
Tönnies, S.
Böttcher, S.
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Ipomoea tyrianthina has been used in Mexican traditional medicine as a mild purgative, for the treatment of nervous disorders, and against tumors. In this study, the effect of convolvulin (an ether-insoluble resin glycoside) from the root of Ipomoea tyrianthina on: Central Nervous System; as spasmolytic and vasodilator; cytotoxic against cancer cell lines is evaluated.

Author(s): 
León-Rivera, Ismael
Herrera-Ruiz, Maribel
Estrada-Soto, Samuel
Gutiérrez, María del Carmen
Martínez-Duncker, Iván
Navarrete-Vázquez, Gabriel
Rios, María Yolanda
Aguilar, Berenice
Castillo-España, Patricia
Aguirre-Moreno, Alma
Publication Title: 
Current Opinion in Obstetrics & Gynecology

PURPOSE OF REVIEW: The percentage of induced live birth has more than doubled from the 1990s to 2008. Induction of labour can either be based on medical indications, or performed as an elective procedure. A large range of pharmacological and non-pharmacological modalities are available for the induction of labour and the optimal method for labour induction is unknown. This article is aimed to examine literature on non-hormonal methods for labour induction, published from January 2012 to May 2013. RECENT FINDINGS: Eleven studies were identified in our search and included into the review.

Author(s): 
Lim, Chi Eung Danforn
Ng, Rachel Wai Chung
Xu, Ke
Publication Title: 
Hypertension Research: Official Journal of the Japanese Society of Hypertension

Night-shift work causes mental stress and lifestyle changes, and is recognized as a risk of cardiovascular diseases associated with impaired endothelial function. Aromatherapy is becoming popular as a complementary therapy that is beneficial for mental relaxation. The purpose of this study was to investigate the effect of aromatherapy on the endothelial function of medical staff after night-shift work. This study consisted of 19 healthy medical personnel (19 men, mean age 32 � 7 years), including 11 physicians and 8 technicians.

Author(s): 
Shimada, Kenei
Fukuda, Shota
Maeda, Kumiko
Kawasaki, Toshihiro
Kono, Yasushi
Jissho, Satoshi
Taguchi, Haruyuki
Yoshiyama, Minoru
Yoshikawa, Junichi
Publication Title: 
Current Pharmaceutical Biotechnology

The stem bark of Terminalia arjuna (Roxb.) is used by the Ayurvedic physicians in India for the treatment of various cardiovascular diseases, collectively referred to as hritroga. It has been extensively studied in animal models to demonstrate cardioprotective properties, ranging from positive inotropic- , hypolipdemic-, coronary vasodilatory- and antioxidant effects to induction of stress protein in heart. Various bioactive compounds, like triterpinoids, tannins, flavonoids and minerals have been isolated from the stem bark.

Author(s): 
Maulik, S. K.
Katiyar, C. K.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: The objectives of this study were to examine the distributions of nitric oxide (NO) in the skin points (acupoints)/meridian regions and determine whether neuronal nitric oxide synthase (nNOS) protein levels were associated with NO concentrations in the areas. DESIGN: Low skin resistance points (LSRP) on the skin surface in response to electrical stimuli were performed in anesthetized adult rats. The skin together with subcutaneous tissue was isolated in meridian regions from PC 2 to 6, BL 36 to 57, CV 3 to 22, and GV 2 to 14.

Author(s): 
Ma, Sheng-Xing

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